日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective STING Activation in Intratumoral Myeloid Cells via CCR2-Directed Antibody-Drug Conjugate TAK-500

通过 CCR2 靶向抗体药物偶联物 TAK-500 选择性激活肿瘤内髓系细胞中的 STING

Vicky A Appleman ,Atsushi Matsuda ,Michelle L Ganno ,Dong Mei Zhang ,Emily Rosentrater ,Angel E Maldonado Lopez ,Angelo Porciuncula ,Tiquella Hatten ,Camilla L Christensen ,Samantha A Merrigan ,Hong Myung Lee ,Min Young Lee ,Charlotte I Wang ,Linlin Dong ,Jian Huang ,Natasha Iartchouk ,Jianing Wang ,He Xu ,Tomoki Yoneyama ,Konstantin I Piatkov ,Satyajeet Haridas ,Carole E Harbison ,Richard C Gregory ,Alexander Parent ,Neil Lineberry ,Chris Arendt ,Kurt A Schalper ,Adnan O Abu-Yousif

Dual Opioid-Neuropeptide FF Small Molecule Ligands Demonstrate Analgesia with Reduced Tolerance Liabilities

双重阿片-神经肽FF小分子配体表现出镇痛作用,且耐受性降低

Mottinelli, Marco; Journigan, V Blair; Obeng, Samuel; Pallares, Victoria L C; Mѐsangeau, Christophe; Kapanda, Coco N; Cutler, Stephen J; Lambert, Janet A; Eans, Shainnel O; Ganno, Michelle L; Sheng, Wanhui; King, Tamara; Sharma, Abhisheak; Mollereau, Catherine; Avery, Bonnie A; McLaughlin, Jay P; McCurdy, Christopher R

Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500

鉴定一种新型连接子,用于STING抗体-药物偶联物TAK-500的环状二核苷酸生物偶联

Lee, Hong Myung; Abdul-Hadi, Kojo; Appleman, Vicky A; Cardin, David; Dong, Linlin; England, Dylan; Ganno, Michelle L; Gershman, Rachel; Gigstad, Kenneth; Gulavita, Nanda; Hu, Zhigen; Huang, Jian; Huang, Shih-Chung; Lok, David; Ma, Liting; Malley, Jenna; Mizutani, Miho; Molchanova, Nina; Piatkov, Konstantin I; Rice, Elise; Shi, Zhan; Vyskocil, Stepan; Wang, Jianing; Xu, He; Xu, Tianlin; Zhang, Dong Mei; Zhang, Ji; Abu-Yousif, Adnan O

Identification and Pharmacological Characterization of a Low-Liability Antinociceptive Bifunctional MOR/DOR Cyclic Peptide

低责任镇痛双功能 MOR/DOR 环肽的鉴定和药理学特性

Yangmei Li, Shainnel O Eans, Michelle Ganno-Sherwood, Abbe Eliasof, Richard A Houghten, Jay P McLaughlin

Pharmacokinetics and Pharmacodynamics of TAK-164 Antibody Drug Conjugate Coadministered with Unconjugated Antibody

TAK-164抗体药物偶联物与未偶联抗体联合给药的药代动力学和药效学

Bruna Menezes #,Eshita Khera #,Melissa Calopiz,Michael D Smith,Michelle L Ganno,Cornelius Cilliers,Adnan O Abu-Yousif,Jennifer J Linderman,Greg M Thurber

Quantifying ADC bystander payload penetration with cellular resolution using pharmacodynamic mapping

使用药效动力学映射以细胞分辨率量化 ADC 旁观者有效载荷渗透

Eshita Khera, Cornelius Cilliers, Michael D Smith, Michelle L Ganno, Katharine C Lai, Thomas A Keating, Anna Kopp, Ian Nessler, Adnan O Abu-Yousif, Greg M Thurber

Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs

噻唑环化DAMGO和Leu-(Met)脑啡肽类似物的镇痛活性

Harris, Hannah M; Eans, Shainnel O; Ganno, Michelle L; Davis, Jennifer C; Dooley, Colette T; McLaughlin, Jay P; Nefzi, Adel

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines

小鼠直接表型筛选:从包含 734,821 个吡咯烷双哌嗪的化合物库中鉴定出单个新型镇痛化合物

Houghten, Richard A; Ganno, Michelle L; McLaughlin, Jay P; Dooley, Colette T; Eans, Shainnel O; Santos, Radleigh G; LaVoi, Travis; Nefzi, Adel; Welmaker, Greg; Giulianotti, Marc A; Toll, Lawrence

Synthesis and characterization of a dual kappa-delta opioid receptor agonist analgesic blocking cocaine reward behavior

双 kappa-delta 阿片受体激动剂镇痛药的合成与表征及阻断可卡因奖励行为

András Váradi, Gina F Marrone, Shainnel O Eans, Michelle L Ganno, Joan J Subrath, Valerie Le Rouzic, Amanda Hunkele, Gavril W Pasternak, Jay P McLaughlin, Susruta Majumdar

Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat

HIV-1 调节蛋白 Tat 的条件性中枢表达导致小鼠出现焦虑样行为

Jason J Paris, Harminder D Singh, Michelle L Ganno, Pauline Jackson, Jay P McLaughlin