Gao Huile相关文献与解析，生知库 | 链接生命科学的每一步

Chauhan, Deepak S; Prasad, Rajendra; Dhanka, Mukesh; Kaur, Navneet; Vithalani, Hitasha; Liyanapathirana, Kaveesha; Hebbandi Nanjundappa, Roopa; Gao, Huile; Umeshappa, Channakeshava Sokke

发表日期：2026

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Leveraging vascular normalization via eNOS activation to enhance the efficacy of PD-L1 blockade

利用eNOS激活实现血管正常化，以增强PD-L1阻断的疗效

期刊:Acta Pharmaceutica Sinica B

影响因子:14.6

doi:10.1016/j.apsb.2026.02.025

Zhou, Yang; Gao, Huile

AI-Driven Drug Discovery: Focus on Targets for Solid Tumors

人工智能驱动的药物发现：聚焦实体瘤靶点

期刊:Pharmaceutics

影响因子:5.5

doi:10.3390/pharmaceutics18030329

Wu, Jialong; He, Jide; Ni, Qianyang; Li, Zi'ang; Lin, Xiushi; Zhao, Zhenkun; Qiu, Lei; Wang, Hongyin; Li, Sijie; Shi, Chengdong; Zhang, Yunyi; Gao, Huile; Lu, Jian

发表日期：2026

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Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery

神经退行性疾病中的蛋白激酶：当前认识及其对药物研发的意义

期刊:Signal Transduction and Targeted Therapy

影响因子:52.7

doi:10.1038/s41392-025-02179-x

Wu, Xiaolei; Yang, Zhangzhong; Zou, Jinjun; Gao, Huile; Shao, Zhenhua; Li, Chuanzhou; Lei, Peng

Targeting modulation of the choroid plexus blood-CSF barrier and CSF hypersecretion via lipid nanoparticle-mediated co-delivery of siRNA and resveratrol.

通过脂质纳米颗粒介导的siRNA和白藜芦醇共递送，靶向调节脉络丛血脑脊液屏障和脑脊液过度分泌

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-61543-1

Wang Qiguang, Xia Xue, Zhang Huan, Li Yue, Zhu Lei, Shi Yulong, Tang Yuzhao, Cheng Jian, Hui Xuhui, Gao Huile

其它

发表日期：2025

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DELIVER: The core principles for the clinic translation of nanomedicines

DELIVER：纳米药物临床转化的核心原则

期刊:Acta Pharmaceutica Sinica B

影响因子:14.6

doi:10.1016/j.apsb.2025.01.014

Hu, Chuan; He, Xinling; Gao, Huile; Zhang, Jinming

发表日期：2025

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Enhanced BBB penetration and microglia-targeting nanomodulator for the two-pronged modulation of chronically activated microglia-mediated neuroinflammation in Alzheimer's disease

增强血脑屏障穿透性和靶向小胶质细胞的纳米调节剂，用于从两个方面调节阿尔茨海默病中慢性激活的小胶质细胞介导的神经炎症

期刊:Acta Pharmaceutica Sinica B

影响因子:14.6

doi:10.1016/j.apsb.2025.01.015

Wei, Ya; Xia, Xue; Wang, Xiaorong; Yang, Wenqin; He, Siqin; Wang, Lulu; Chen, Yongke; Zhou, Yang; Chen, Feng; Li, Hanmei; Peng, Fu; Li, Guobo; Xu, Zheng; Fu, Jintao; Gao, Huile

Emerging therapeutic strategies: The potential of caffeic acid-vanadium nanozymes in modulating macrophage function and reducing skin flap ischemia-reperfusion injury

新兴治疗策略：咖啡酸-钒纳米酶在调节巨噬细胞功能和减少皮瓣缺血再灌注损伤方面的潜力

期刊:Acta Pharmaceutica Sinica B

影响因子:14.6

doi:10.1016/j.apsb.2025.01.012

Fu, Jintao; Gao, Huile

Nose-to-brain delivery of targeted lipid nanoparticles as two-pronged β-amyloid nanoscavenger for Alzheimer's disease therapy

鼻腔至脑部递送靶向脂质纳米颗粒作为双管齐下的β-淀粉样蛋白纳米清除剂用于阿尔茨海默病治疗

期刊:Acta Pharmaceutica Sinica B

影响因子:14.6

doi:10.1016/j.apsb.2025.02.035

Xu, Yanyan; Ye, Xiangtong; Du, Yanfeng; Yang, Wenqin; Tong, Fan; Li, Wei; Huang, Qianqian; Chen, Yongke; Li, Hanmei; Gao, Huile; Zhang, Weiwei

Engineered tumor specific AAV for IL-12 delivery in ovarian cancer immunotherapy

用于卵巢癌免疫治疗的肿瘤特异性AAV载体，可递送IL-12。

期刊:Acta Pharmaceutica Sinica B

影响因子:14.6

doi:10.1016/j.apsb.2025.05.033

Tong, Fan; Li, Hanmei; Gao, Huile; Li, Yuan

Nanoparticles-based phototherapy systems: molecular mechanisms and clinical applications

基于纳米颗粒的光疗系统：分子机制和临床应用

Leveraging vascular normalization via eNOS activation to enhance the efficacy of PD-L1 blockade

利用eNOS激活实现血管正常化，以增强PD-L1阻断的疗效

AI-Driven Drug Discovery: Focus on Targets for Solid Tumors

人工智能驱动的药物发现：聚焦实体瘤靶点

Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery

神经退行性疾病中的蛋白激酶：当前认识及其对药物研发的意义

Targeting modulation of the choroid plexus blood-CSF barrier and CSF hypersecretion via lipid nanoparticle-mediated co-delivery of siRNA and resveratrol.

通过脂质纳米颗粒介导的siRNA和白藜芦醇共递送，靶向调节脉络丛血脑脊液屏障和脑脊液过度分泌

DELIVER: The core principles for the clinic translation of nanomedicines

DELIVER：纳米药物临床转化的核心原则

Enhanced BBB penetration and microglia-targeting nanomodulator for the two-pronged modulation of chronically activated microglia-mediated neuroinflammation in Alzheimer's disease

增强血脑屏障穿透性和靶向小胶质细胞的纳米调节剂，用于从两个方面调节阿尔茨海默病中慢性激活的小胶质细胞介导的神经炎症

Emerging therapeutic strategies: The potential of caffeic acid-vanadium nanozymes in modulating macrophage function and reducing skin flap ischemia-reperfusion injury

新兴治疗策略：咖啡酸-钒纳米酶在调节巨噬细胞功能和减少皮瓣缺血再灌注损伤方面的潜力

Nose-to-brain delivery of targeted lipid nanoparticles as two-pronged β-amyloid nanoscavenger for Alzheimer's disease therapy

鼻腔至脑部递送靶向脂质纳米颗粒作为双管齐下的β-淀粉样蛋白纳米清除剂用于阿尔茨海默病治疗

Engineered tumor specific AAV for IL-12 delivery in ovarian cancer immunotherapy

用于卵巢癌免疫治疗的肿瘤特异性AAV载体，可递送IL-12。