日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tissue-specific mutagenesis from endogenous guanine damage is suppressed by Polκ and DNA repair

内源性鸟嘌呤损伤引起的组织特异性突变受到Polκ和DNA修复的抑制。

Jiang, Yang; Przybilla, Moritz; Bakker, Linda; Jacobs, Foster C; Mckeon, Dylan; van der Sluijs, Roxanne; Sato, Koichi; Wezenbeek, Juliëtte; van Strien, Joeri; Willems, Jeroen; Verkennis, Alexander E E; Barnett, Jamie; Ortega, Adrian Baez; Abascal, Federico; Villalta, Peter W; Knipscheer, Puck; Martincorena, Inigo; Balbo, Silvia; Garaycoechea, Juan

Corrigendum to "Cross talk between the liver microbiome and epigenome in patients with metabolic dysfunction-associated steatotic liver disease"

关于“代谢功能障碍相关脂肪肝患者肝脏微生物组与表观基因组之间的相互作用”一文的更正

Pirola, Carlos Jose; Salatino, Adrian; Fernández Gianotti, Tomas; Castaño, Gustavo Osvaldo; Garaycoechea, Martin; Sookoian, Silvia

Primordial germ cell DNA demethylation and development require DNA translesion synthesis

原始生殖细胞DNA去甲基化和发育需要DNA跨损伤合成

Pranay Shah,Ross Hill,Camille Dion,Stephen J Clark,Abdulkadir Abakir,Jeroen Willems,Mark J Arends,Juan I Garaycoechea,Harry G Leitch,Wolf Reik,Gerry P Crossan

p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice

p53调控小鼠体内内源性DNA损伤的多种组织特异性结果

Ross J Hill ,Nazareno Bona ,Job Smink ,Hannah K Webb ,Alastair Crisp ,Juan I Garaycoechea ,Gerry P Crossan

Cross talk between the liver microbiome and epigenome in patients with metabolic dysfunction-associated steatotic liver disease

代谢功能障碍相关脂肪肝患者肝脏微生物组与表观基因组之间的相互作用

Pirola, Carlos Jose; Salatino, Adrian; Fernández Gianotti, Tomas; Castaño, Gustavo Osvaldo; Garaycoechea, Martin; Sookoian, Silvia

Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner

基因毒性醛类应激以p53驱动的方式使造血干细胞过早衰老。

Meng Wang ,Laura T L Brandt ,Xiaonan Wang ,Holly Russell ,Emily Mitchell ,Ashley N Kamimae-Lanning ,Jill M Brown ,Felix A Dingler ,Juan I Garaycoechea ,Tomoya Isobe ,Sarah J Kinston ,Muxin Gu ,George S Vassiliou ,Nicola K Wilson ,Berthold Göttgens ,Ketan J Patel

Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements

人类神经元单细胞基因组测序发现调控元件中存在体细胞点突变和插入缺失富集。

Lovelace J Luquette # ,Michael B Miller # ,Zinan Zhou # ,Craig L Bohrson ,Yifan Zhao ,Hu Jin ,Doga Gulhan ,Javier Ganz ,Sara Bizzotto ,Samantha Kirkham ,Tino Hochepied ,Claude Libert ,Alon Galor ,Junho Kim ,Michael A Lodato ,Juan I Garaycoechea ,Charles Gawad ,Jay West ,Christopher A Walsh ,Peter J Park

The influence of host genetics on liver microbiome composition in patients with NAFLD

宿主遗传因素对非酒精性脂肪性肝病患者肝脏微生物组组成的影响

Pirola, Carlos Jose; Salatino, Adrian; Quintanilla, Maria Florencia; Castaño, Gustavo Osvaldo; Garaycoechea, Martin; Sookoian, Silvia

Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response

醛驱动的转录应激引发厌食性DNA损伤反应

Lee Mulderrig #, Juan I Garaycoechea #, Zewen K Tuong, Christopher L Millington, Felix A Dingler, John R Ferdinand, Liam Gaul, John A Tadross, Mark J Arends, Stephen O'Rahilly, Gerry P Crossan, Menna R Clatworthy, Ketan J Patel

XPF-ERCC1 protects liver, kidney and blood homeostasis outside the canonical excision repair pathways

XPF-ERCC1 在典型切除修复途径之外保护肝脏、肾脏和血液稳态

Lee Mulderrig, Juan I Garaycoechea