日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering

通过捕获键工程克服T细胞对肿瘤自身抗原的耐受性

Chen, Xiaojing; Mao, Zhiyuan; Kolawole, E Motunrayo; Persechino, Margherita; Jude, Kevin M; Ogishi, Masato; Mo, Kelvin C; McLaughlin, Jami; Cheng, Donghui; Xiang, Xinyu; Yang, Xinbo; Gee, Caitlin; Liu, Shiqin; Yang, Aerin; Obenaus, Matthias; Wang, Nan; Noguchi, Miyako; Stoyanova, Tanya; Lee, John K; Good, Zinaida; Latorraca, Naomi R; Evavold, Brian D; Witte, Owen N; Garcia, K Christopher

Structural ontogeny of protein-protein interactions

蛋白质-蛋白质相互作用的结构发育

Yang, Aerin; Jiang, Hanlun; Jude, Kevin M; Akpinaroglu, Deniz; Allenspach, Stephan; Li, Alex Jie; Bowden, James; Perez, Carla Patricia; Liu, Liu; Huang, Po-Ssu; Kortemme, Tanja; Listgarten, Jennifer; Garcia, K Christopher

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.

针对老年大脑中的免疫细胞的研究表明,工程细胞因子 IL-10 可以增强神经发生并改善认知能力。

Navarro Negredo Paloma, You Justin, Hauptschein Max, Schroer Adam B, Richard Daniel J, Abhiraman Gita C, Tsai Andy P, Sun Eric D, Notarangelo Giulia, Ramirez-Matias Julliana, Zhou Olivia Y, Buckley Matthew T, Malacon Karen E, Xu Lucy, Sucharov Juliana, Ramirez Lopez Eduardo, Picton Lora, Wyss-Coray Tony, Saxton Robert A, Fernandes Ricardo A, Villeda Saul A, Garcia K Christopher, Brunet Anne

Design of solubly expressed miniaturized SMART MHCs.

可溶性表达的微型化SMART MHC的设计。

White William L, Bai Hua, Kim Chan Jhong, Jude Kevin M, Sun Renhua, Guerrero Laura, Han Xiao, Chen Xiaojing, Chaudhuri Apala, Bonzanini Julia E, Sun Yi, Onwuka Amarachi E, Wang Nan, Wang Chunyu, Nygren Per-Ã ke, Li Xinting, Goreshnik Inna, Allen Aza, Levine Paul M, Kueh Hao Yuan, Jewett Michael C, Sgourakis Nikolaos G, Achour Adnane, Garcia K Christopher, Baker David

T cell engagers control solid tumors through clonal replacement and IL2-driven effector differentiation of CD8 T cells

T细胞衔接器通过克隆替代和IL2驱动的CD8 T细胞效应分化来控制实体瘤

Obenaus, Matthias; Poupault, Clara L; McGinnis, Christopher S; Prange, Céline; Jiang, Hua; Su, Leon L; Chen, Xiaojing; Miao, Zhuang; Muldoon, Joseph J; Yao, Winnie; Waghray, Deepa; Sun, Qinli; Eyquem, Justin; Hernández-López, Rogelio A; Satpathy, Ansuman T; Sage, Julien; Garcia, K Christopher

Systematic mapping of emergent transcriptional states in interacting single-cell dyads by Cell-Cell-seq

利用细胞-细胞测序技术系统地绘制相互作用的单细胞二元体中涌现的转录状态图谱

Baghdasarian, Sevana; Wang, Qingyang; Langerman, Justin; Mao, Zhiyuan; Wright, Heather; Gee, Caitlin; Cheng, Donghui; McLaughlin, Jami; Lee, John K; Chen, Xiaojing; Garcia, K Christopher; Li, Jingyi Jessica; Witte, Owen N; Plath, Kathrin; Di Carlo, Dino

Predicting targeted- and immunotherapeutic response outcomes in melanoma with single-cell Raman spectroscopy and AI

利用单细胞拉曼光谱和人工智能预测黑色素瘤靶向治疗和免疫治疗的反应结果

Chang, Kai; Serasanambati, Mamatha; Ogunlade, Baba; Hsu, Hsiu-Ju; Agolia, James; Stiber, Ariel; Gu, Jeffrey; Chadokiya, Jay; Rodriguez, Grayson E; Singh, Prabhjeet; Sharma, Saurabh; Gonçalves, Amanda; Verma, Ojasvi; Safir, Fareeha; Vu, Nhat; Garcia, K Christopher; Delitto, Daniel; Kirane, Amanda; Dionne, Jennifer A

Selective Immune Silencing by Targeted TGF-β Agonists.

靶向TGF-β激动剂选择性免疫沉默。

Sun Qinli, Ogishi Masato, Jiang Hua, Barrett Alison K, Yan Hao, Sola Elsa, Zhang Jie, Xiao Peng, Lyu Huiyun, Salehi Ahmad, Tang Qizhi, Lanz Tobias V, Davis Mark M, Negrin Robert S, Garcia K Christopher

De novo design and structure of a peptide-centric TCR mimic binding module

从头设计和构建以肽为中心的TCR模拟结合模块

Householder, Karsten D; Xiang, Xinyu; Jude, Kevin M; Deng, Arthur; Obenaus, Matthias; Zhao, Yang; Wilson, Steven C; Chen, Xiaojing; Wang, Nan; Garcia, K Christopher

Design of high-specificity binders for peptide-MHC-I complexes

肽-MHC-I复合物高特异性结合剂的设计

Liu, Bingxu; Greenwood, Nathan F; Bonzanini, Julia E; Motmaen, Amir; Meyerberg, Jeremy; Dao, Tao; Xiang, Xinyu; Ault, Russell; Sharp, Jazmin; Wang, Chunyu; Visani, Gian Marco; Vafeados, Dionne K; Roullier, Nicole; Nourmohammad, Armita; Scheinberg, David A; Garcia, K Christopher; Baker, David