日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rescue of male infertility by human PRSS55 in transgenic mice establishes a contraceptive research model

利用转基因小鼠中的人类PRSS55基因挽救雄性不育症,建立了一种避孕研究模型。

Sutton, Courtney M; Umezu, Kohei; Mashiko, Daisuke; Ikawa, Masahito; Larina, Irina V; Garcia, Thomas X; Matzuk, Martin M

Ovochymase 2 is a key regulatory factor modulating proteolytic pathways and sperm maturation in the mammalian epididymis†.

卵黄酶 2 是调节哺乳动物附睾中蛋白水解途径和精子成熟的关键调控因子

Kent Katarzyna, Nozawa Kaori, Jain Antrix, Malovannaya Anna, Garcia Thomas X, Matzuk Martin M

Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice.

通过 CRISPR/Cas9 系统单独破坏 12 个睾丸富集基因并不影响雄性小鼠的生育能力

Suzuki Akira, Yabuta Norikazu, Shimada Keisuke, Mashiko Daisuke, Tokuhiro Keizo, Oyama Yuki, Miyata Haruhiko, Garcia Thomas X, Matzuk Martin M, Ikawa Masahito

Bringing proteomics to bear on male fertility: key lessons

将蛋白质组学应用于男性生育力研究:关键经验

Parkes, Rachel; Garcia, Thomas X

Novel Genes of the Male Reproductive System: Potential Roles in Male Reproduction and as Non-hormonal Male Contraceptive Targets

男性生殖系统的新基因:在男性生殖中的潜在作用以及作为非激素男性避孕靶点的可能性

Garcia, Thomas X; Matzuk, Martin M

SLO3 in the fast lane: The latest male contraceptive target with a promising small-molecule inhibitor

SLO3 处于快速发展阶段:最新的男性避孕靶点,一种前景广阔的小分子抑制剂正在研发中。

Tan, Zhi; Garcia, Thomas X

CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice

利用 CRISPR/Cas9 介导的基因组编辑技术,揭示了小鼠睾丸中 12 个对雄性生育能力并非必需的基因。

Oyama, Yuki; Miyata, Haruhiko; Shimada, Keisuke; Fujihara, Yoshitaka; Tokuhiro, Keizo; Garcia, Thomas X; Matzuk, Martin M; Ikawa, Masahito

Toward Development of the Male Pill: A Decade of Potential Non-hormonal Contraceptive Targets

男性避孕药的研发之路:十年来非激素避孕药的潜在靶点

Kent, Katarzyna; Johnston, Madelaine; Strump, Natasha; Garcia, Thomas X

CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction†

利用 CRISPR/Cas9 技术对小鼠进行基因组编辑,发现 13 个在睾丸或附睾中富集的基因,这些基因对雄性生殖并非各自独立发挥作用†

Sun, Jiang; Lu, Yonggang; Nozawa, Kaori; Xu, Zoulan; Morohoshi, Akane; Castaneda, Julio M; Noda, Taichi; Miyata, Haruhiko; Abbasi, Ferheen; Shawki, Hossam H; Takahashi, Satoru; Devlin, Darius J; Yu, Zhifeng; Matzuk, Ryan M; Garcia, Thomas X; Matzuk, Martin M; Ikawa, Masahito

CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†

CRISPR/Cas9介导的基因组编辑揭示了小鼠睾丸中30个对雄性生育能力并非必需的基因†

Lu, Yonggang; Oura, Seiya; Matsumura, Takafumi; Oji, Asami; Sakurai, Nobuyuki; Fujihara, Yoshitaka; Shimada, Keisuke; Miyata, Haruhiko; Tobita, Tomohiro; Noda, Taichi; Castaneda, Julio M; Kiyozumi, Daiji; Zhang, Qian; Larasati, Tamara; Young, Samantha A M; Kodani, Mayo; Huddleston, Caitlin A; Robertson, Matthew J; Coarfa, Cristian; Isotani, Ayako; Aitken, R John; Okabe, Masaru; Matzuk, Martin M; Garcia, Thomas X; Ikawa, Masahito