日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Long-acting parathyroid hormone receptor agonist rectifies hypocalcemia in autosomal dominant hypocalcemia type 1 mice

长效甲状旁腺激素受体激动剂可纠正常染色体显性低钙血症1型小鼠的低钙血症。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI201759
Hannan, Fadil M; Stevenson, Mark; Elajnaf, Taha; Rostom, Hussam; Lines, Kate E; Stewart, Michelle; Wells, Sara; Moir, Lee; Gardella, Thomas J; Thakker, Rajesh V
信号转导
免疫/内分泌
发表日期：2026
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Prolonging parathyroid hormone analog action in vitro and in vivo through peptide lipidation.

通过肽脂化延长甲状旁腺激素类似物在体外和体内的作用

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-59665-7
Höppner Jakob, Noda Hiroshi, Anitha Anju Krishnan, Cheloha Ross W, Dean Thomas, Bruce Michael, Brooks Daniel J, Mannstadt Michael, Bouxsein Mary L, Gellman Samuel H, Khatri Ashok, Jüppner Harald, Gardella Thomas J
免疫/内分泌
发表日期：2025
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A mouse model of Jansen's metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics.

詹森氏干骺端软骨发育不良的小鼠模型，用于研究疾病机制和候选疗法

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2500176122
Höppner Jakob, Firat Damla, Parvez-Khan Mohd, Reyes Monica, Hanna Patrick, Yadav Prem Swaroop, Dean Thomas, Ramos-Torres Karla M, Brugarolas Pedro, Collins Michael T, Wein Marc N, Liu Shi, Gellman Samuel H, Schipani Ernestina, Kronenberg Henry M, Gardella Thomas J, Jüppner Harald
骨科研究
Mouse
发表日期：2025
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Human diseases caused by homozygous PTH1R mutations

由PTH1R纯合突变引起的人类疾病

期刊:Frontiers in Endocrinology
影响因子:4.6
doi:10.3389/fendo.2025.1641292
Portales-Castillo, Ignacio; Höppner, Jakob; Jüppner, Harald; Gardella, Thomas J
PTH1R
Human
PTH
发表日期：2025
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Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants

骨架修饰提供了一种长效的致病性、组成型活性 PTH1R 变体的反向激动剂

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.3c09694
Liu, Shi; Daley, Eileen J; Tran, Lauren My-Linh; Yu, Zhen; Reyes, Monica; Dean, Thomas; Khatri, Ashok; Levine, Paul M; Balana, Aaron T; Pratt, Matthew R; Jüppner, Harald; Gellman, Samuel H; Gardella, Thomas J
PTH1R
PTH
发表日期：2024
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Eiken syndrome with parathyroid hormone resistance due to a novel parathyroid hormone receptor type 1 mutation: clinical features and functional analysis.

因新型甲状旁腺激素受体 1 型突变引起的甲状旁腺激素抵抗的 Eiken 综合征：临床特征和功能分析

期刊:Journal of Bone and Mineral Research
影响因子:5.9
doi:10.1093/jbmr/zjae148
Calder Alistair D, Allgrove Jeremy, Höppner Jakob, Cheung Moira, Alexander Saji, Garagnani Lorenzo, Thakker Rajesh, Jüppner Harald, Gardella Thomas J, Holder-Espinasse Muriel
信号转导
免疫/内分泌
发表日期：2024
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Substantially Delayed Maturation of Growth Plate Chondrocytes in "Humanized" PTH1R Mice with the H223R Mutation of Jansen's Disease

在携带詹森氏病H223R突变的“人源化”PTH1R小鼠中，生长板软骨细胞的成熟显著延迟

期刊:JBMR Plus
影响因子:2.4
doi:10.1002/jbm4.10802
Reyes, Monica; Firat, Damla; Hanna, Patrick; Khan, Mohd; Bruce, Michael; Shvedova, Maria; Kobayashi, Tatsuya; Schipani, Ernestina; Gardella, Thomas J; Jüppner, Harald
PTH1R
细胞生物学
PTH
Human
发表日期：2023
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Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo

PTH受体通过改变激动剂与胞外结构域的接触而导致的信号传导改变，为体内延长激动作用提供了途径。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2212736119
Liu, Shi; Yu, Zhen; Daley, Eileen J; Bingman, Craig A; Bruchs, Austin T; Gardella, Thomas J; Gellman, Samuel H
信号转导
PTH
发表日期：2022
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Activity-based, bioorthogonal imaging of phospholipase D reveals spatiotemporal dynamics of GPCR-Gq signaling.

基于活性的生物正交成像技术揭示了磷脂酶 D 的 GPCR-Gq 信号传导的时空动态

期刊:Cell Chemical Biology
影响因子:7.2
doi:10.1016/j.chembiol.2021.05.020
Liang Dongjun, Cheloha Ross W, Watanabe Tomoyuki, Gardella Thomas J, Baskin Jeremy M
信号转导
发表日期：2022
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Biased GPCR signaling by the native parathyroid hormone-related protein 1 to 141 relative to its N-terminal fragment 1 to 36

天然甲状旁腺激素相关蛋白1至141相对于其N端片段1至36的偏向性GPCR信号传导

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2022.102332
Peña, Karina A; White, Alex D; Savransky, Sofya; Castillo, Ignacio Portales; Jean-Alphonse, Frédéric G; Gardella, Thomas J; Sutkeviciute, Ieva; Vilardaga, Jean-Pierre
信号转导
GPCR/Calcium/cAMP
免疫/内分泌
发表日期：2022
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