日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

PP2A-Integrator-CDK9轴精细调控转录,可作为癌症治疗的靶点。

Stephin J Vervoort,Sarah A Welsh,Jennifer R Devlin,Elisa Barbieri,Deborah A Knight,Sarah Offley,Stefan Bjelosevic,Matteo Costacurta,Izabela Todorovski,Conor J Kearney,Jarrod J Sandow,Zheng Fan,Benjamin Blyth,Victoria McLeod,Joseph H A Vissers,Karolina Pavic,Ben P Martin,Gareth Gregory,Elena Demosthenous,Magnus Zethoven,Isabella Y Kong,Edwin D Hawkins,Simon J Hogg,Madison J Kelly,Andrea Newbold,Kaylene J Simpson,Otto Kauko,Kieran F Harvey,Michael Ohlmeyer,Jukka Westermarck,Nathanael Gray,Alessandro Gardini,Ricky W Johnstone

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

通过抑制催化性P300/CBP来靶向组蛋白乙酰化动态和致癌转录

Simon J Hogg ,Olga Motorna ,Leonie A Cluse ,Timothy M Johanson ,Hannah D Coughlan ,Ramya Raviram ,Robert M Myers ,Matteo Costacurta ,Izabela Todorovski ,Lizzy Pijpers ,Stefan Bjelosevic ,Tobias Williams ,Shannon N Huskins ,Conor J Kearney ,Jennifer R Devlin ,Zheng Fan ,Jafar S Jabbari ,Ben P Martin ,Mohamed Fareh ,Madison J Kelly ,Daphné Dupéré-Richer ,Jarrod J Sandow ,Breon Feran ,Deborah Knight ,Tiffany Khong ,Andrew Spencer ,Simon J Harrison ,Gareth Gregory ,Vihandha O Wickramasinghe ,Andrew I Webb ,Phillippa C Taberlay ,Kenneth D Bromberg ,Albert Lai ,Anthony T Papenfuss ,Gordon K Smyth ,Rhys S Allan ,Jonathan D Licht ,Dan A Landau ,Omar Abdel-Wahab ,Jake Shortt ,Stephin J Vervoort ,Ricky W Johnstone

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

CDK13 与 CDK12 协同控制整体 RNA 聚合酶 II 的持续性

Zheng Fan, Jennifer R Devlin, Simon J Hogg, Maria A Doyle, Paul F Harrison, Izabela Todorovski, Leonie A Cluse, Deborah A Knight, Jarrod J Sandow, Gareth Gregory, Andrew Fox, Traude H Beilharz, Nicholas Kwiatkowski, Nichollas E Scott, Ana Tufegdzic Vidakovic, Gavin P Kelly, Jesper Q Svejstrup, Matth

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis

Bcor 缺失会干扰髓系分化并促进白血病形成

Madison J Kelly, Joan So, Amy J Rogers, Gareth Gregory, Jason Li, Magnus Zethoven, Micah D Gearhart, Vivian J Bardwell, Ricky W Johnstone, Stephin J Vervoort, Lev M Kats