日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

一种RIPK1特异性PROTAC降解剂通过增强免疫原性细胞死亡实现强效抗肿瘤活性

Jonathan Mannion ,Valentina Gifford ,Benjamin Bellenie ,Winnie Fernando ,Laura Ramos Garcia ,Rebecca Wilson ,Sidonie Wicky John ,Savita Udainiya ,Emmanuel C Patin ,Crescens Tiu ,Angel Smith ,Maria Goicoechea ,Andrew Craxton ,Nathalia Moraes de Vasconcelos ,Naomi Guppy ,Kwai-Ming J Cheung ,Nicholas J Cundy ,Olivier Pierrat ,Alfie Brennan ,Theodoros I Roumeliotis ,Graeme Benstead-Hume ,John Alexander ,Gareth Muirhead ,Scott Layzell ,Wenxin Lyu ,Victoria Roulstone ,Mark Allen ,Holly Baldock ,Arnaud Legrand ,Florian Gabel ,Natalia Serrano-Aparicio ,Chris Starling ,Hongyan Guo ,Jason Upton ,Mads Gyrd-Hansen ,Marion MacFarlane ,Benedict Seddon ,Florence Raynaud ,Ioannis Roxanis ,Kevin Harrington ,Syed Haider ,Jyoti S Choudhary ,Swen Hoelder ,Tencho Tenev ,Pascal Meier

SF3B1 hotspot mutations confer sensitivity to PARP inhibition by eliciting a defective replication stress response

SF3B1 热点突变通过引发有缺陷的复制应激反应而赋予对 PARP 抑制的敏感性

Philip Bland, Harry Saville, Patty T Wai, Lucinda Curnow, Gareth Muirhead, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie Beatrix John, Somaieh Hedayat, Holly E Barker, James Wright, Lu Yu, Ioanna Mavrommati, Abigail Read, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen N Pemberton, Aditi Gulati,

3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer

3D功能基因组学筛选发现CREBBP是侵袭性三阴性乳腺癌的可靶向驱动基因

Barrie Peck,Philip Bland #,Ioanna Mavrommati #,Gareth Muirhead #,Hannah Cottom,Patty T Wai,Sarah L Maguire,Holly E Barker,Eamonn Morrison,Divya Kriplani,Lu Yu,Amy Gibson,Giulia Falgari,Keith Brennan,Gillian Farnie,Richard Buus,Rebecca Marlow,Daniela Novo,Eleanor Knight,Naomi Guppy,Daniela Kolarevic,Snezana Susnjar,Natasa Medic Milijic,Kalnisha Naidoo,Patrycja Gazinska,Ioannis Roxanis,Sunil Pancholi,Lesley-Ann Martin,Erle M Holgersen,Maggie C U Cheang,Farzana Noor,Sophie Postel-Vinay  ,Gerard Quinn,Simon McDade,Lukas Krasny,Paul Huang,Frances Daley,Fredrik Wallberg,Jyoti S Choudhary,Syed Haider,Andrew N Tutt,Rachael Natrajan

Combining BRAF inhibition with oncolytic herpes simplex virus enhances the immune-mediated antitumor therapy of BRAF-mutant thyroid cancer

BRAF 抑制与溶瘤单纯疱疹病毒相结合可增强 BRAF 突变型甲状腺癌的免疫介导抗肿瘤治疗

Eva Crespo-Rodriguez, Katharina Bergerhoff, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Harriet Whittock, Richard Buus, Syed Haider, Gareth Muirhead, Khin Thway, Kate Newbold, Robert S Coffin, Richard G Vile, Dae Kim, Martin McLaughlin, Alan A Melcher, Kevin J Harrington, Malin Pedersen

SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells

SOX11促进上皮/间质混合状态的形成并改变侵袭性乳腺癌细胞的趋向性

Erik Oliemuller ,Richard Newman ,Siu Man Tsang ,Shane Foo ,Gareth Muirhead ,Farzana Noor ,Syed Haider ,Iskander Aurrekoetxea-Rodríguez ,Maria dM Vivanco ,Beatrice A Howard

Microbe-host interplay in atopic dermatitis and psoriasis

特应性皮炎和银屑病中的微生物-宿主相互作用

Nanna Fyhrquist # ,Gareth Muirhead # ,Stefanie Prast-Nielsen # ,Marine Jeanmougin # ,Peter Olah ,Tiina Skoog ,Gerome Jules-Clement ,Micha Feld ,Mauricio Barrientos-Somarribas ,Hanna Sinkko ,Ellen H van den Bogaard ,Patrick L J M Zeeuwen ,Gijs Rikken ,Joost Schalkwijk ,Hanna Niehues ,Walter Däubener ,Silvia Kathrin Eller ,Helen Alexander ,Davide Pennino ,Sari Suomela ,Ioannis Tessas ,Emilia Lybeck ,Anna M Baran ,Hamid Darban ,Roopesh Singh Gangwar ,Ulrich Gerstel ,Katharina Jahn ,Piia Karisola ,Lee Yan ,Britta Hansmann ,Shintaro Katayama ,Stephan Meller ,Max Bylesjö ,Philippe Hupé ,Francesca Levi-Schaffer ,Dario Greco ,Annamari Ranki ,Jens M Schröder ,Jonathan Barker ,Juha Kere ,Sophia Tsoka ,Antti Lauerma ,Vassili Soumelis ,Frank O Nestle ,Bernhard Homey ,Björn Andersson ,Harri Alenius

PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer

PARP 抑制可增强 ERCC1 缺陷型非小细胞肺癌的肿瘤细胞内在免疫力

Roman M Chabanon, Gareth Muirhead, Dragomir B Krastev, Julien Adam, Daphné Morel, Marlène Garrido, Andrew Lamb, Clémence Hénon, Nicolas Dorvault, Mathieu Rouanne, Rebecca Marlow, Ilirjana Bajrami, Marta Llorca Cardeñosa, Asha Konde, Benjamin Besse, Alan Ashworth, Stephen J Pettitt, Syed Haider, Auré