日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy

通过模板跳跃策略鉴定一系列新型且具有选择性的 Itk 抑制剂

Catherine M Alder, Martin Ambler, Amanda J Campbell, Aurelie C Champigny, Angela M Deakin, John D Harling, Carol A Harris, Tim Longstaff, Sean Lynn, Aoife C Maxwell, Chris J Mooney, Callum Scullion, Onkar M P Singh, Ian E D Smith, Donald O Somers, Christopher J Tame, Gareth Wayne, Caroline Wilson, J

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo

口服强效选择性非肽类 BACE-1 抑制剂可降低体内淀粉样蛋白前体的 β 裂解和淀粉样蛋白 β 的产生

Ishrut Hussain, Julie Hawkins, David Harrison, Christopher Hille, Gareth Wayne, Leanne Cutler, Tania Buck, Daryl Walter, Emmanuel Demont, Colin Howes, Alan Naylor, Philip Jeffrey, Maria I Gonzalez, Colin Dingwall, Anton Michel, Sally Redshaw, John B Davis

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase

硫酸肝素通过 BACE1(阿尔茨海默氏症 β-分泌酶)调节淀粉样蛋白前体蛋白的加工

Zoe Scholefield, Edwin A Yates, Gareth Wayne, Augustin Amour, William McDowell, Jeremy E Turnbull