日期 影响因子
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2020 年 — 2026 年
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影响因子:
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X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase

对与人源化脂肪酸酰胺水解酶变体结合的α-酮杂环抑制剂进行X射线晶体学分析

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/jm9012196
Mileni, Mauro; Garfunkle, Joie; Ezzili, Cyrine; Kimball, F Scott; Cravatt, Benjamin F; Stevens, Raymond C; Boger, Dale L
代谢
发表日期：2010
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Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures

共晶结构揭示了α-酮杂环抑制剂对人源化脂肪酸酰胺水解酶的结合和失活机制

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/ja902694n
Mileni, Mauro; Garfunkle, Joie; DeMartino, Jessica K; Cravatt, Benjamin F; Boger, Dale L; Stevens, Raymond C
代谢
发表日期：2009
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Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase

脂肪酸酰胺水解酶α-酮杂环抑制剂中心杂环的优化

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/jm800136b
Garfunkle, Joie; Ezzili, Cyrine; Rayl, Thomas J; Hochstatter, Dustin G; Hwang, Inkyu; Boger, Dale L
代谢
发表日期：2008
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Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase

α-酮杂环酶抑制剂的基本取代基效应研究：高效选择性脂肪酸酰胺水解酶抑制剂

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2008.06.084
DeMartino, Jessica K; Garfunkle, Joie; Hochstatter, Dustin G; Cravatt, Benjamin F; Boger, Dale L
代谢
发表日期：2008
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Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase

抑制剂对整合膜蛋白脂肪酸酰胺水解酶的酶活性和热稳定性的影响相关性

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2008.06.086
Slaymaker, Ian M; Bracey, Michael; Mileni, Mauro; Garfunkle, Joie; Cravatt, Benjamin F; Boger, Dale L; Stevens, Raymond C
代谢
发表日期：2008
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