日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions

MLKL 缺乏可独立于坏死性凋亡功能增加雄性小鼠的睾酮生成

Shene Chiou, Wayne Cawthorne, Thomas Soerianto, Vinzenz Hofferek, Komal M Patel, Sarah E Garnish, Emma C Tovey Crutchfield, Cathrine Hall, Joanne M Hildebrand, Malcolm J McConville, Kate E Lawlor, Edwin D Hawkins #, Andre L Samson #, James M Murphy #3

Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation

抑制剂确定了 mTOR 信号在 MLKL 激活下游坏死性凋亡执行中的辅助作用

Sarah E Garnish, Christopher R Horne, Yanxiang Meng, Samuel N Young, Annette V Jacobsen, Joanne M Hildebrand, James M Murphy

Coxiella burnetii protein CBU2016 supports CCV expansion

伯氏柯克斯体蛋白CBU2016支持CCV的扩增

Thomas, David R; Garnish, Sarah E; Khoo, Chen Ai; Padmanabhan, Bhavna; Scott, Nichollas E; Newton, Hayley J

Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization

磷酸化依赖性假激酶结构域二聚化驱动全长 MLKL 寡聚化

Yanxiang Meng #, Sarah E Garnish #, Katherine A Davies, Katrina A Black, Andrew P Leis, Christopher R Horne, Joanne M Hildebrand, Hanadi Hoblos, Cheree Fitzgibbon, Samuel N Young, Toby Dite, Laura F Dagley, Aarya Venkat, Natarajan Kannan, Akiko Koide, Shohei Koide, Alisa Glukhova, Peter E Czabotar, 

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

人类常见的 MLKL 多态性可抵抗磷酸化的负向调控

Sarah E Garnish, Katherine R Martin, Maria Kauppi, Victoria E Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C Tovey Crutchfield, Komal M Patel, Annette V Jacobsen, Georgia K Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R Horne, Cathrine Hall, S

MLKL deficiency protects against low-grade, sterile inflammation in aged mice

MLKL 缺乏可预防老年小鼠的低度无菌性炎症

Emma C Tovey Crutchfield #, Sarah E Garnish #, Jessica Day, Holly Anderton, Shene Chiou, Anne Hempel, Cathrine Hall, Komal M Patel, Pradnya Gangatirkar, Katherine R Martin, Connie S N Li Wai Suen, Alexandra L Garnham, Andrew J Kueh, Ian P Wicks, John Silke, Ueli Nachbur, Andre L Samson, James M Murp

Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL

膜通透性由小鼠和人类坏死性凋亡效应物 MLKL 的直系同源物中的不同表位介导

Ashish Sethi #, Christopher R Horne #, Cheree Fitzgibbon, Karyn Wilde, Katherine A Davies, Sarah E Garnish, Annette V Jacobsen, André L Samson, Joanne M Hildebrand, Ahmad Wardak, Peter E Czabotar, Emma J Petrie, Paul R Gooley, James M Murphy

Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death

RIPK3 在 RHIM 之外的泛素化可限制 RIPK3 活性和细胞死亡

Daniel Frank, Sarah E Garnish, Jarrod J Sandow, Ashley Weir, Lin Liu, Elise Clayer, Lizeth Meza, Maryam Rashidi, Simon A Cobbold, Simon R Scutts, Marcel Doerflinger, Holly Anderton, Kate E Lawlor, Najoua Lalaoui, Andrew J Kueh, Vik Ven Eng, Rebecca L Ambrose, Marco J Herold, Andre L Samson, Rebecca

Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway

罕见灾难与进化遗产:MLKL 和坏死性凋亡信号通路中的人类种系基因变异

Garnish, Sarah E; Hildebrand, Joanne M

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

MLKL 的构象相互转化和与 RIPK3 的脱离先于细胞坏死性凋亡而死亡

Sarah E Garnish #, Yanxiang Meng #, Akiko Koide #, Jarrod J Sandow, Eric Denbaum, Annette V Jacobsen, Wayland Yeung, Andre L Samson, Christopher R Horne, Cheree Fitzgibbon, Samuel N Young, Phoebe P C Smith, Andrew I Webb, Emma J Petrie, Joanne M Hildebrand, Natarajan Kannan, Peter E Czabotar, Shohei