日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Safety and pharmacokinetics of antifungal agent VT-1598 and its primary metabolite, VT-11134, in healthy adult subjects: phase 1, first-in-human, randomized, double-blind, placebo-controlled study of single-ascending oral doses of VT-1598

抗真菌药物VT-1598及其主要代谢物VT-11134在健康成年受试者中的安全性和药代动力学：一项首次人体随机、双盲、安慰剂对照的1期研究，评估单次递增口服剂量VT-1598的疗效。

期刊:Medical Mycology
影响因子:2.3
doi:10.1093/mmy/myae032
Gu, Kenan; Spitz, Robert; Hammett, Erin; Jaunarajs, Anna; Ghazaryan, Varduhi; Garvey, Edward P; Degenhardt, Thorsten
微生物学
代谢
发表日期：2024
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In Vitro Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of Candida albicans

新型研究性四唑类化合物VT-1161和VT-1598与三唑类抗真菌药物对耐唑类菌株和临床分离的白色念珠菌的体外活性比较

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.00341-19
Nishimoto, Andrew T; Wiederhold, Nathan P; Flowers, Stephanie A; Zhang, Qing; Kelly, Steven L; Morschhäuser, Joachim; Yates, Christopher M; Hoekstra, William J; Schotzinger, Robert J; Garvey, Edward P; Rogers, P David
微生物学
发表日期：2019
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Impact of the Major Candida glabrata Triazole Resistance Determinants on the Activity of the Novel Investigational Tetrazoles VT-1598 and VT-1161

主要光滑念珠菌三唑耐药性决定因素对新型研究性四唑类药物VT-1598和VT-1161活性的影响

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.01304-19
Nishimoto, Andrew T; Whaley, Sarah G; Wiederhold, Nathan P; Zhang, Qing; Yates, Christopher M; Hoekstra, William J; Schotzinger, Robert J; Garvey, Edward P; Rogers, P David
发表日期：2019
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The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris

真菌 Cyp51 特异性抑制剂 VT-1598 在体外和体内均表现出对耳念珠菌的活性

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.02233-18
Wiederhold, Nathan P; Lockhart, Shawn R; Najvar, Laura K; Berkow, Elizabeth L; Jaramillo, Rosie; Olivo, Marcos; Garvey, Edward P; Yates, Christopher M; Schotzinger, Robert J; Catano, Gabriel; Patterson, Thomas F
微生物学
发表日期：2019
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1346. The Tetrazole VT-1598 Is Efficacious in a Murine Model of Invasive Aspergillosis with a PK/PD Expected of a Mold-Active CYP51 Inhibitor

1346. 四唑类药物 VT-1598 在侵袭性曲霉病小鼠模型中有效，其药代动力学/药效学特征符合抗霉菌 CYP51 抑制剂的预期。

期刊:Pharmaceuticals
影响因子:4.8
doi:10.3390/ph12010022
Szudzik, Mateusz; Starzyński, Rafał R; Jończy, Aneta; Mazgaj, Rafał; Lenartowicz, Małgorzata; Lipiński, Paweł; Garvey, Edward P; Sharp, Andrew; Warn, Peter; Yates, Christopher M; Schotzinger, Robert J
发表日期：2018
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The Novel Fungal Cyp51 Inhibitor VT-1598 Is Efficacious in Experimental Models of Central Nervous System Coccidioidomycosis Caused by Coccidioides posadasii and Coccidioides immitis

新型真菌CYP51抑制剂VT-1598对由波萨达斯球孢子菌和粗球孢子菌引起的中枢神经系统球孢子菌病实验模型有效

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.02258-17
Wiederhold, Nathan P; Shubitz, Lisa F; Najvar, Laura K; Jaramillo, Rosie; Olivo, Marcos; Catano, Gabriel; Trinh, Hien T; Yates, Christopher M; Schotzinger, Robert J; Garvey, Edward P; Patterson, Thomas F
微生物学
神经科学
发表日期：2018
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The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis

真菌CYP51抑制剂VT-1129在隐球菌性脑膜炎的实验模型中有效

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.01071-18
Wiederhold, Nathan P; Najvar, Laura K; Garvey, Edward P; Brand, Stephen R; Xu, Xin; Ottinger, Elizabeth A; Alimardanov, Asaf; Cradock, Jim; Behnke, Mark; Hoekstra, William J; Schotzinger, Robert J; Jaramillo, Rosie; Olivo, Marcos; Kirkpatrick, William R; Patterson, Thomas F
微生物学
神经科学
发表日期：2018
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In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy

采用负荷剂量-维持剂量给药策略，评估VT-1129对实验性隐球菌性脑膜炎的体内疗效

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.01315-18
Wiederhold, Nathan P; Xu, Xin; Wang, Amy; Najvar, Laura K; Garvey, Edward P; Ottinger, Elizabeth A; Alimardanov, Asaf; Cradock, Jim; Behnke, Mark; Hoekstra, William J; Brand, Stephen R; Schotzinger, Robert J; Jaramillo, Rosie; Olivo, Marcos; Kirkpatrick, William R; Patterson, Thomas F
神经科学
发表日期：2018
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VT-1161 protects mice against oropharyngeal candidiasis caused by fluconazole-susceptible and -resistant Candida albicans

VT-1161 可保护小鼠免受对氟康唑敏感和耐药的白色念珠菌引起的口咽念珠菌病的侵害。

期刊:Journal of Antimicrobial Chemotherapy
影响因子:3.6
doi:10.1093/jac/dkx352
Break, Timothy J; Desai, Jigar V; Natarajan, Mukil; Ferre, Elise M N; Henderson, Christina; Zelazny, Adrian M; Siebenlist, Ulrich; Hoekstra, William J; Schotzinger, Robert J; Garvey, Edward P; Lionakis, Michail S
发表日期：2018
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VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice

VT-1598 可抑制黏膜念珠菌菌株的体外生长，并能保护 IL-17 信号通路缺陷小鼠免受氟康唑敏感和耐药性口腔念珠菌病的侵害。

期刊:Journal of Antimicrobial Chemotherapy
影响因子:3.6
doi:10.1093/jac/dky170
Break, Timothy J; Desai, Jigar V; Healey, Kelley R; Natarajan, Mukil; Ferre, Elise M N; Henderson, Christina; Zelazny, Adrian; Siebenlist, Ulrich; Yates, Christopher M; Cohen, Oren J; Schotzinger, Robert J; Perlin, David S; Garvey, Edward P; Lionakis, Michail S
IL-17
信号转导
发表日期：2018
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