日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Broad-Spectrum Multi-Antigen mRNA/LNP-Based Pan-Coronavirus Vaccine Induced Potent Cross-Protective Immunity Against Infection and Disease Caused by Highly Pathogenic and Heavily Spike-Mutated SARS-CoV-2 Variants of Concern in the Syrian Hamster Model

基于广谱多抗原 mRNA/LNP 的泛冠状病毒疫苗在叙利亚仓鼠模型中诱导了针对高致病性和严重刺突突变的 SARS-CoV-2 变体引起的感染和疾病的强效交叉保护性免疫

Swayam Prakash, Nisha R Dhanushkodi, Mahmoud Singer, Afshana Quadiri, Latifa Zayou, Hawa Vahed, Pierre-Gregoire Coulon, Izabela Coimbra Ibraim, Christine Tafoya, Lauren Hitchcock, Gary Landucci, Donald N Forthal, Assia El Babsiri, Delia F Tifrea, Cesar J Figueroa, Anthony B Nesburn, Baruch D Kupperm

Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations

慢性感染期间广泛中和 HIV 抗体的频率很低,即使是针对含有大量体细胞突变的四级表位抗体

Mark D Hicar, Xuemin Chen, Spyros A Kalams, Hakimuddin Sojar, Gary Landucci, Donald N Forthal, Paul Spearman, James E Crowe Jr

Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques

人类非中和性HIV-1包膜单克隆抗体可限制恒河猴SHIV黏膜感染期间的创始病毒数量

Sampa Santra ,Georgia D Tomaras ,Ranjit Warrier ,Nathan I Nicely ,Hua-Xin Liao ,Justin Pollara ,Pinghuang Liu ,S Munir Alam ,Ruijun Zhang ,Sarah L Cocklin ,Xiaoying Shen ,Ryan Duffy ,Shi-Mao Xia ,Robert J Schutte ,Charles W Pemble Iv ,S Moses Dennison ,Hui Li ,Andrew Chao ,Kora Vidnovic ,Abbey Evans ,Katja Klein ,Amit Kumar ,James Robinson ,Gary Landucci ,Donald N Forthal ,David C Montefiori ,Jaranit Kaewkungwal ,Sorachai Nitayaphan ,Punnee Pitisuttithum ,Supachai Rerks-Ngarm ,Merlin L Robb ,Nelson L Michael ,Jerome H Kim ,Kelly A Soderberg ,Elena E Giorgi ,Lily Blair ,Bette T Korber ,Christiane Moog ,Robin J Shattock ,Norman L Letvin ,Joern E Schmitz ,M A Moody ,Feng Gao ,Guido Ferrari ,George M Shaw ,Barton F Haynes

Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose

使用多克隆抗 SHIV IgG 对恒河猴进行被动免疫,以对抗异源 2 级 SHIV:结果取决于 IgG 剂量

Anton M Sholukh, Siddappa N Byrareddy, Vivekanandan Shanmuganathan, Girish Hemashettar, Samir K Lakhashe, Robert A Rasmussen, Jennifer D Watkins, Hemant K Vyas, Swati Thorat, Tania Brandstoetter, Muhammad M Mukhtar, John K Yoon, Francis J Novembre, Francois Villinger, Gary Landucci, Donald N Forthal

Chemically modified peptides based on the membrane-proximal external region of the HIV-1 envelope induce high-titer, epitope-specific nonneutralizing antibodies in rabbits

基于 HIV-1 包膜近端外部区域的化学修饰肽可在兔体内诱导高滴度、表位特异性非中和抗体

Vincent J Venditto, Lindsay Wieczorek, Sebastian Molnar, Fernando Teque, Gary Landucci, Douglas S Watson, Donald Forthal, Victoria R Polonis, Jay A Levy, Francis C Szoka Jr

The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells

新生儿 Fc 受体 (FcRn) 增强人类免疫缺陷病毒 1 型 (HIV-1) 跨上皮细胞的转胞吞作用

Sandeep Gupta, Johannes S Gach, Juan C Becerra, Tran B Phan, Jeffrey Pudney, Zina Moldoveanu, Sarah B Joseph, Gary Landucci, Medalyn Jude Supnet, Li-Hua Ping, Davide Corti, Brian Moldt, Zdenek Hel, Antonio Lanzavecchia, Ruth M Ruprecht, Dennis R Burton, Jiri Mestecky, Deborah J Anderson, Donald N Fo

Neutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques

急性感染期间存在的中和多克隆 IgG 可防止感染猿人免疫缺陷病毒 SHIVSF162P3 的幼年恒河猴快速发病

J Pablo Jaworski, James Kobie, Zachary Brower, Delphine C Malherbe, Gary Landucci, William F Sutton, Biwei Guo, Jason S Reed, Enrique J Leon, Flora Engelmann, Bo Zheng, Al Legasse, Byung Park, Mary Dickerson, Anne D Lewis, Lois M A Colgin, Michael Axthelm, Ilhem Messaoudi, Jonah B Sacha, Dennis R Bu

Rapid high-level production of functional HIV broadly neutralizing monoclonal antibodies in transient plant expression systems

在瞬时植物表达系统中快速高效地生产功能性 HIV 广谱中和单克隆抗体

Yvonne Rosenberg, Markus Sack, David Montefiori, Donald Forthal, Lingjun Mao, Segundo Hernandez-Abanto, Lori Urban, Gary Landucci, Rainer Fischer, Xiaoming Jiang

A nonfucosylated variant of the anti-HIV-1 monoclonal antibody b12 has enhanced FcγRIIIa-mediated antiviral activity in vitro but does not improve protection against mucosal SHIV challenge in macaques

抗 HIV-1 单克隆抗体 b12 的非岩藻糖基化变体在体外增强了 FcγRIIIa 介导的抗病毒活性,但并未提高恒河猴对粘膜 SHIV 攻击的保护作用

Brian Moldt, Mami Shibata-Koyama, Eva G Rakasz, Niccole Schultz, Yutaka Kanda, D Cameron Dunlop, Samantha L Finstad, Chenggang Jin, Gary Landucci, Michael D Alpert, Anne-Sophie Dugast, Paul W H I Parren, Falk Nimmerjahn, David T Evans, Galit Alter, Donald N Forthal, Jörn E Schmitz, Shigeru Iida, Pas

Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal

感染 SIV K65R 逆转录酶突变体的恒河猴长期接受替诺福韦治疗,可产生抗病毒免疫反应,从而控制停药后的病毒复制

Koen K A Van Rompay, Kristin A Trott, Kartika Jayashankar, Yongzhi Geng, Celia C LaBranche, Jeffrey A Johnson, Gary Landucci, Jonathan Lipscomb, Ross P Tarara, Don R Canfield, Walid Heneine, Donald N Forthal, David Montefiori, Kristina Abel