日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters

CRISPR 和生化筛选表明 MAZ 是 CTCF 介导的 Hox 簇绝缘的辅助因子

Havva Ortabozkoyun, Pin-Yao Huang, Hyunwoo Cho, Varun Narendra, Gary LeRoy, Edgar Gonzalez-Buendia, Jane A Skok, Aristotelis Tsirigos, Esteban O Mazzoni, Danny Reinberg

RNA-Mediated Feedback Control of Transcriptional Condensates

RNA 介导的转录凝聚物的反馈控制

Jonathan E Henninger, Ozgur Oksuz, Krishna Shrinivas, Ido Sagi, Gary LeRoy, Ming M Zheng, J Owen Andrews, Alicia V Zamudio, Charalampos Lazaris, Nancy M Hannett, Tong Ihn Lee, Phillip A Sharp, Ibrahim I Cissé, Arup K Chakraborty, Richard A Young

The H3K36me2 writer-reader dependency in H3K27M-DIPG

H3K27M-DIPG 中的 H3K36me2 写入器-读取器依赖性

Jia-Ray Yu, Gary LeRoy, Devin Bready, Joshua D Frenster, Ricardo Saldaña-Meyer, Ying Jin, Nicolas Descostes, James M Stafford, Dimitris G Placantonakis, Danny Reinberg

MeCP2 links heterochromatin condensates and neurodevelopmental disease

MeCP2 将异染色质凝聚物与神经发育疾病联系起来

Charles H Li #, Eliot L Coffey #, Alessandra Dall'Agnese, Nancy M Hannett, Xin Tang, Jonathan E Henninger, Jesse M Platt, Ozgur Oksuz, Alicia V Zamudio, Lena K Afeyan, Jurian Schuijers, X Shawn Liu, Styliani Markoulaki, Tenzin Lungjangwa, Gary LeRoy, Devon S Svoboda, Emile Wogram, Tong Ihn Lee, Rudo

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells

LEDGF 和 HDGF2 缓解分化细胞中核小体诱导的转录障碍

Gary LeRoy, Ozgur Oksuz, Nicolas Descostes, Yuki Aoi, Rais A Ganai, Havva Ortabozkoyun Kara, Jia-Ray Yu, Chul-Hwan Lee, James Stafford, Ali Shilatifard, Danny Reinberg

Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma

PRC2 的自甲基化促进 H3K27 甲基化,并且在 H3K27M 儿童胶质瘤中受损

Chul-Hwan Lee #, Jia-Ray Yu #, Jeffrey Granat #, Ricardo Saldaña-Meyer, Joshua Andrade, Gary LeRoy, Ying Jin, Peder Lund, James M Stafford, Benjamin A Garcia, Beatrix Ueberheide, Danny Reinberg

Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin

变构激活决定 PRC2 活性,与其对染色质的募集无关

Chul-Hwan Lee, Jia-Ray Yu, Sunil Kumar, Ying Jin, Gary LeRoy, Natarajan Bhanu, Syuzo Kaneko, Benjamin A Garcia, Andrew D Hamilton, Danny Reinberg

Capturing the Onset of PRC2-Mediated Repressive Domain Formation

捕捉 PRC2 介导的抑制结构域形成的开始

Ozgur Oksuz, Varun Narendra, Chul-Hwan Lee, Nicolas Descostes, Gary LeRoy, Ramya Raviram, Lili Blumenberg, Kelly Karch, Pedro P Rocha, Benjamin A Garcia, Jane A Skok, Danny Reinberg

Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2

不同的刺激机制调节多梳抑制复合物 2 的催化活性

Chul-Hwan Lee, Marlene Holder, Daniel Grau, Ricardo Saldaña-Meyer, Jia-Ray Yu, Rais Ahmad Ganai, Jenny Zhang, Miao Wang, Gary LeRoy, Marc-Werner Dobenecker, Danny Reinberg, Karim-Jean Armache

Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma

多种 PRC2 抑制模式可引发 H3K27M 儿童胶质瘤的整体染色质改变

James M Stafford, Chul-Hwan Lee, Philipp Voigt, Nicolas Descostes, Ricardo Saldaña-Meyer, Jia-Ray Yu, Gary Leroy, Ozgur Oksuz, Jessica R Chapman, Fernando Suarez, Aram S Modrek, N Sumru Bayin, Dimitris G Placantonakis, Matthias A Karajannis, Matija Snuderl, Beatrix Ueberheide, Danny Reinberg