日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3.

单价伪天然产物可加速 IDO1 的天然 E3 KLHDC3 的降解。

Hennes Elisabeth, Lucas Belén, Scholes Natalie S, Cheng Xiu-Fen, Scott Daniel C, Bischoff Matthias, Reich Katharina, Gasper Raphael, Lucas María, Xu Teng Teng, Rossini Sofia, Pulvermacher Lisa-Marie, Dötsch Lara, Imrichova Hana, Brause Alexandra, Führer Siska, Naredla Kesava Reddy, Sievers Sonja, Kumar Kamal, Janning Petra, Orabona Ciriana, Gersch Malte, Murray Peter J, Schulman Brenda A, Winter Georg E, Ziegler Slava, Waldmann Herbert

Design, Synthesis, and Structural Evolution of Pseudo-Natural Product IDO1 Inhibitors and Degraders

拟天然产物IDO1抑制剂和降解剂的设计、合成和结构演变

Cheng, Xiu-Fen; Lucas, Belén; Lampe, Philipp; Ugel, Stefano; Chen, Suyuan; Unger, Anke; Bischoff, Matthias; Adariani, Soheila Rezaei; Naredla, Kesava Reddy; Kumar, Kamal; Schmidt, Annika; Strohmann, Carsten; Janning, Petra; Gasper, Raphael; Lucas, María; Gersch, Malte; Sievers, Sonja; Bronte, Vincenzo; Ziegler, Slava; Waldmann, Herbert

Covalent modification of a glutamic acid inspired by HaloTag technology.

受 HaloTag 技术启发,对谷氨酸进行共价修饰。

Zhang Ruirui, Liu Jie, Gasper Raphael, Unger Anke, Kaschani Farnusch, Kaiser Markus, Janning Petra, Waldmann Herbert

Targeting a Glutamic Acid in PDEδ with Fluoromethyl-Aryl Electrophiles Impairs K-Ras Signaling

用氟甲基-芳基亲电试剂靶向PDEδ中的谷氨酸会损害K-Ras信号传导

Zhang, Ruirui; Huetzen, Maxim A; Binici, Aylin; Martín-Gago, Pablo; Gasper, Raphael; Rudashevskaya, Elena; Liu, Jie; Nagaraju, Chinta; Reckzeh, Elena S; Stuedle, Alana S T; Hopff, Ann-Sophie; Mesaros, Andrea; Unger, Anke; Thelen, Melanie; Janning, Petra; Reinhardt, H Christian; Ziegler, Slava; Jachimowicz, Ron D; Waldmann, Herbert

Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1 mRNA splicing

利用吲哚骨架鉴定调节 XBP1 mRNA 剪接的小分子 IRE1α 抑制剂

Liu, Yang; Avathan Veettil, Amrutha K; Gasper, Raphael; Jiang, Mao; Wagner, Leon; Hastürk, Oguz; Wu, Peng

Identification of a Monovalent Pseudo-Natural Product Degrader Class Supercharging Degradation of IDO1 by its native E3 KLHDC3

鉴定出一种单价伪天然产物降解剂,该降解剂可显著增强其天然 E3 酶 KLHDC3 对 IDO1 的降解作用

Hennes, Elisabeth; Lucas, Belén; Scholes, Natalie S; Cheng, Xiu-Fen; Scott, Daniel C; Bischoff, Matthias; Reich, Katharina; Gasper, Raphael; Lucas, María; Xu, Teng Teng; Pulvermacher, Lisa-Marie; Dötsch, Lara; Imrichova, Hana; Brause, Alexandra; Naredla, Kesava Reddy; Sievers, Sonja; Kumar, Kamal; Janning, Petra; Gersch, Malte; Murray, Peter J; Schulman, Brenda A; Winter, Georg E; Ziegler, Slava; Waldmann, Herbert

Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding

合理设计的环状肽通过变构作用抑制PTBP1-RNA结合

Schmeing, Stefan; Amrahova, Gulshan; Bigler, Katrin; Chang, Jen-Yao; Openy, Joseph; Pal, Sunit; Posada, Laura; Gasper, Raphael; 't Hart, Peter

Synthesis of 20-Membered Macrocyclic Pseudo-Natural Products Yields Inducers of LC3 Lipidation

20元大环拟天然产物的合成可诱导LC3脂化

Niggemeyer, Georg; Knyazeva, Anastasia; Gasper, Raphael; Corkery, Dale; Bodenbinder, Pia; Holstein, Julian J; Sievers, Sonja; Wu, Yao-Wen; Waldmann, Herbert

Identification of a Novel Pseudo-Natural Product Type IV IDO1 Inhibitor Chemotype

鉴定一种新型拟天然产物IV型IDO1抑制剂化学类型

Davies, Caitlin; Dötsch, Lara; Ciulla, Maria Gessica; Hennes, Elisabeth; Yoshida, Kei; Gasper, Raphael; Scheel, Rebecca; Sievers, Sonja; Strohmann, Carsten; Kumar, Kamal; Ziegler, Slava; Waldmann, Herbert

Biochemical Investigation of the Interaction of pICln, RioK1 and COPR5 with the PRMT5-MEP50 Complex

pICln、RioK1 和 COPR5 与 PRMT5-MEP50 复合物相互作用的生化研究

Krzyzanowski, Adrian; Gasper, Raphael; Adihou, Hélène; Hart, Peter 't; Waldmann, Herbert