Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome
MAT2A的缺失会损害蛋氨酸代谢,并通过调控表观基因组,成为H3K27M突变型胶质瘤的一个脆弱点。
期刊:Nature Cancer
影响因子:23.5
doi:10.1038/s43018-022-00348-3
Brian J Golbourn ,Matthew E Halbert ,Katharine Halligan ,Srinidhi Varadharajan ,Brian Krug ,Nneka E Mbah ,Nisha Kabir ,Ann-Catherine J Stanton ,Abigail L Locke ,Stephanie M Casillo ,Yanhua Zhao ,Lauren M Sanders ,Allison Cheney ,Steven J Mullett ,Apeng Chen ,Michelle Wassell ,Anthony Andren ,Jennifer Perez ,Esther P Jane ,Daniel R David Premkumar ,Robert F Koncar ,Shideh Mirhadi ,Lauren H McCarl ,Yue-Fang Chang ,Yijen L Wu ,Taylor A Gatesman ,Andrea F Cruz ,Michal Zapotocky ,Baoli Hu ,Gary Kohanbash ,Xiuxing Wang ,Alenoush Vartanian ,Michael F Moran ,Frank Lieberman ,Nduka M Amankulor ,Stacy G Wendell ,Olena M Vaske ,Ashok Panigrahy ,James Felker ,Kelsey C Bertrand ,Claudia L Kleinman ,Jeremy N Rich ,Robert M Friedlander ,Alberto Broniscer ,Costas Lyssiotis ,Nada Jabado ,Ian F Pollack ,Stephen C Mack ,Sameer Agnihotri