Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation
二甲双胍通过抑制线粒体ATP和DNA合成,阻断NLRP3炎症小体的激活和肺部炎症。
期刊:Immunity
影响因子:25.5
doi:10.1016/j.immuni.2021.05.004
Hongxu Xian ,Yuan Liu ,Alexandra Rundberg Nilsson ,Raphaella Gatchalian ,Timothy R Crother ,Warren G Tourtellotte ,Yi Zhang ,German R Aleman-Muench ,Gavin Lewis ,Weixuan Chen ,Sarah Kang ,Melissa Luevanos ,Dorit Trudler ,Stuart A Lipton ,Pejman Soroosh ,John Teijaro ,Juan Carlos de la Torre ,Moshe Arditi ,Michael Karin ,Elsa Sanchez-Lopez
NLRP3
炎症/感染
LRP3
线粒体
免疫/内分泌
肺炎
炎性小体
炎症
炎性小体