日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Road map for primary hepatocyte qualification in human liver organ models

人类肝脏器官模型中原代肝细胞鉴定的路线图

Varmazyad, Mahboubeh; Gavlock, Dillon C; Castiglione, Michael W; DeBiasio, Richard; LaRocca, Gregory; Reese, Celeste; Vernetti, Lawrence A; Schurdak, Mark; Stern, Andrew M; Taylor, D Lansing; Miedel, Mark T; Brown, Jacquelyn A

Human-induced pluripotent stem cell-based hepatic modeling of lipid metabolism-associated TM6SF2-E167K variant

基于人诱导多能干细胞的脂质代谢相关TM6SF2-E167K变体肝脏模型

Faccioli, Lanuza A P; Sun, Yiyue; Animasahun, Olamide; Motomura, Takashi; Liu, Zhenghao; Kurihara, Takeshi; Hu, Zhiping; Yang, Bo; Cetin, Zeliha; Baratta, Annalisa M; Shankaran, Ajay; Nenwani, Minal; Altay, Leyla Nurcihan; Huang, Linqi; Meurs, Noah; Franks, Jonathan; Stolz, Donna; Gavlock, Dillon C; Miedel, Mark T; Ostrowska, Alina; Florentino, Rodrigo M; Fox, Ira J; Nagrath, Deepak; Soto-Gutierrez, Alejandro

PNPLA3-I148M genetic variant rewires lipid metabolism to drive programmed cell death in human hepatocytes

PNPLA3-I148M基因变异重塑脂质代谢,从而驱动人类肝细胞程序性细胞死亡

Florentino, Rodrigo M; Animasahun, Olamide; Haep, Nils; Nenwani, Minal; Omoloja, Kehinde; Altay, Leyla Nurcihan; Achreja, Abhinav; Morita, Kazutoyo; Motomura, Takashi; Diaz-Aragon, Ricardo; Faccioli, Lanuza Ap; Sun, Yiyue; Liu, Zhenghao; Hu, Zhiping; Yang, Bo; Wuchu, Fulei; Shankaran, Ajay; Paserba, Miya; Baratta, Annalisa M; Arazov, Shohrat; Kocas-Kilicarslan, Zehra N; Meurs, Noah; Behari, Jaideep; Tafaleng, Edgar N; Franks, Jonathan; Ostrowska, Alina; Tomiyama, Takahiro; Yugawa, Kyohei; Morinaga, Akinari; Wang, Zi; Takeishi, Kazuki; Gavlock, Dillon C; Miedel, Mark; Taylor, D Lansing; Fox, Ira J; Yoshizumi, Tomoharu; Nagrath, Deepak; Soto-Gutierrez, Alejandro

Validation of microphysiological systems for interpreting patient heterogeneity requires robust reproducibility analytics and experimental metadata

验证用于解释患者异质性的微生理系统需要可靠的可重复性分析和实验元数据。

Miedel, Mark T; Varmazyad, Mahboubeh; Xia, Mengying; Brooks, Maria Mori; Gavlock, Dillon C; Reese, Celeste; Behari, Jaideep; Soto-Gutierrez, Alejandro; Gough, Albert; Taylor, D Lansing; Schurdak, Mark E

Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency

发现并验证突变型磷酸丙糖异构酶 (TPI) 小分子稳定剂作为 TPI 缺乏症的潜在先导化合物

Vollmer, Laura L; Roberts, Presley; Eicher, Samantha L; Wołosowicz, Marta; Patel, Priyal; Figura, Joseph R; Donahue, Ella R; Berkowitz, Josh; Gavlock, Dillon; Wipf, Peter; LaPorte, Matt; Mullett, Steven J; Shillington, Amelle; Homanics, Gregg E; Palladino, Michael J; Vogt, Andreas

A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system

一种与代谢功能障碍相关的脂肪肝腺泡仿生模型在耦合微生理系统中诱导胰岛功能障碍。

Julio Aleman # ,Ravikumar K # ,Connor Wiegand # ,Mark E Schurdak ,Lawrence Vernetti ,Dillon Gavlock ,Celeste Reese ,Richard DeBiasio ,Greg LaRocca ,Yulder Daniel Angarita ,Albert Gough ,Alejandro Soto-Gutierrez ,Jaideep Behari ,Vijay K Yechoor ,Mark T Miedel ,Andrew M Stern ,Ipsita Banerjee ,D Lansing Taylor

Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy

在人体仿生肝脏微生理系统中比较野生型和高风险PNPLA3变异体,以用于代谢功能障碍相关脂肪肝疾病的精准治疗。

Mengying Xia # ,Mahboubeh Varmazyad # ,Iris Pla-Palacín # ,Dillon C Gavlock ,Richard DeBiasio ,Gregory LaRocca ,Celeste Reese ,Rodrigo M Florentino ,Lanuza A P Faccioli ,Jacquelyn A Brown ,Lawrence A Vernetti ,Mark Schurdak ,Andrew M Stern ,Albert Gough ,Jaideep Behari ,Alejandro Soto-Gutierrez ,D Lansing Taylor # ,Mark T Miedel #

Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors

利用荧光蛋白生物传感器量化人体仿生肝脏微生理系统中非酒精性脂肪肝疾病的进展

Saydmohammed, Manush; Jha, Anupma; Mahajan, Vineet; Gavlock, Dillon; Shun, Tong Ying; DeBiasio, Richard; Lefever, Daniel; Li, Xiang; Reese, Celeste; Kershaw, Erin E; Yechoor, Vijay; Behari, Jaideep; Soto-Gutierrez, Alejandro; Vernetti, Larry; Stern, Andrew; Gough, Albert; Miedel, Mark T; Lansing Taylor, D

Modeling the Effect of the Metastatic Microenvironment on Phenotypes Conferred by Estrogen Receptor Mutations Using a Human Liver Microphysiological System

使用人类肝脏微生理系统模拟转移性微环境对雌激素受体突变所致表型的影响

Mark T Miedel, Dillon C Gavlock, Shanhang Jia, Albert Gough, D Lansing Taylor, Andrew M Stern