日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A phase I study to evaluate the safety, pharmacokinetics, and pharmacodynamics of PF-06939999 (PRMT5 inhibitor) in patients with selected advanced or metastatic tumors with high incidence of splicing factor gene mutations

一项 I 期研究，旨在评估 PF-06939999（PRMT5 抑制剂）在具有高发剪接因子基因突变的特定晚期或转移性肿瘤患者中的安全性、药代动力学和药效学。

期刊:ESMO Open
影响因子:8.3
doi:10.1016/j.esmoop.2024.102961
Rodon, J; Rodriguez, E; Maitland, M L; Tsai, F Y-C; Socinski, M A; Berlin, J D; Thomas, J S; Al Baghdadi, T; Wang, I-M; Guo, C; Golmakani, M; Clark, L N; Gazdoiu, M; Li, M; Tolcher, A W
肿瘤
肿瘤免疫
发表日期：2024
文献求助 收藏

Ribociclib, a CDK 4/6 inhibitor, plus endocrine therapy in Asian women with advanced breast cancer

利博西尼（一种 CDK 4/6 抑制剂）联合内分泌疗法用于治疗亚洲晚期乳腺癌女性患者

期刊:Cancer Science
影响因子:4.3
doi:10.1111/cas.14554
Yap, Yoon-Sim; Chiu, Joanne; Ito, Yoshinori; Ishikawa, Takashi; Aruga, Tomoyuki; Kim, Seung Jin; Toyama, Tatsuya; Saeki, Toshiaki; Saito, Mitsue; Gounaris, Ioannis; Su, Fei; Ji, Yan; Han, Yu; Gazdoiu, Mihaela; Masuda, Norikazu
肿瘤
肿瘤免疫
乳腺癌
发表日期：2020
文献求助 收藏

Efficacy and Safety of Pembrolizumab in Patients Enrolled in KEYNOTE-030 in the United States: An Expanded Access Program

在美国参与 KEYNOTE-030 研究的患者中，帕博利珠单抗的疗效和安全性：一项扩大用药计划

期刊:Journal of Immunotherapy
影响因子:2.9
doi:10.1097/CJI.0000000000000186
Gangadhar, Tara C; Hwu, Wen-Jen; Postow, Michael A; Hamid, Omid; Daud, Adil; Dronca, Roxana; Joseph, Richard; O'Day, Steven J; Hodi, F S; Pavlick, Anna C; Kluger, Harriet; Oxborough, Romina P; Yang, Aiming; Gazdoiu, Mihaela; Kush, Debra A; Ebbinghaus, Scot; Salama, April K S
发表日期：2017
文献求助 收藏

Functional Brachyury binding sites establish a temporal read-out of gene expression in the Ciona notochord

功能性短尾蛋白结合位点在海鞘脊索中建立了基因表达的时间读取机制

期刊:PLoS Biology
影响因子:7.2
doi:10.1371/journal.pbio.1001697
Katikala, Lavanya; Aihara, Hitoshi; Passamaneck, Yale J; Gazdoiu, Stefan; José-Edwards, Diana S; Kugler, Jamie E; Oda-Ishii, Izumi; Imai, Janice H; Nibu, Yutaka; Di Gregorio, Anna
发表日期：2013
文献求助 收藏

Slc25a12 disruption alters myelination and neurofilaments: a model for a hypomyelination syndrome and childhood neurodevelopmental disorders

Slc25a12基因缺失会改变髓鞘形成和神经丝：一种髓鞘形成不足综合征和儿童神经发育障碍的模型

期刊:Biological Psychiatry
影响因子:9
doi:10.1016/j.biopsych.2009.08.042
Sakurai, Takeshi; Ramoz, Nicolas; Barreto, Marta; Gazdoiu, Mihaela; Takahashi, Nagahide; Gertner, Michael; Dorr, Nathan; Gama Sosa, Miguel A; De Gasperi, Rita; Perez, Gissel; Schmeidler, James; Mitropoulou, Vivian; Le, H Carl; Lupu, Mihaela; Hof, Patrick R; Elder, Gregory A; Buxbaum, Joseph D
发育与干细胞
神经科学
发表日期：2010
文献求助 收藏

Temporal regulation of the muscle gene cascade by Macho1 and Tbx6 transcription factors in Ciona intestinalis

海鞘中 Macho1 和 Tbx6 转录因子对肌肉基因级联的时间调控

期刊:Journal of Cell Science
影响因子:3.6
doi:10.1242/jcs.066910
Kugler, Jamie E; Gazdoiu, Stefan; Oda-Ishii, Izumi; Passamaneck, Yale J; Erives, Albert J; Di Gregorio, Anna
信号转导
发表日期：2010
文献求助 收藏

Antibody targeting of cathepsin S inhibits angiogenesis and synergistically enhances anti-VEGF

靶向组织蛋白酶S的抗体可抑制血管生成，并协同增强抗VEGF作用。

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0012543
Ward, Claire; Kuehn, Diana; Burden, Roberta E; Gormley, Julie A; Jaquin, Thomas J; Gazdoiu, Mihaela; Small, Donna; Bicknell, Roy; Johnston, James A; Scott, Christopher J; Olwill, Shane A
VEGF
EGF
血管生成
发表日期：2010
文献求助 收藏

Interactions between the L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylation

L1 细胞粘附分子与埃兹蛋白之间的相互作用支持牵引力的产生，并可通过酪氨酸磷酸化进行调节

期刊:Journal of Neuroscience Research
影响因子:2.9
doi:10.1002/jnr.21705
Takeshi Sakurai, Orlando D Gil, John D Whittard, Mihaela Gazdoiu, Todd Joseph, James Wu, Adam Waksman, Deanna L Benson, Stephen R Salton, Dan P Felsenfeld
免疫
细胞生物学
其它细胞
Apoptosis
发表日期：2008
文献求助 收藏

Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2

缺氧诱导脯氨酰羟化酶PHD3组装成复合物：对其活性和易被E3连接酶Siah2降解的影响

期刊:Biochemical Journal
影响因子:4.3
doi:10.1042/BJ20061135
Nakayama, Koh; Gazdoiu, Stefan; Abraham, Robert; Pan, Zhen-Qiang; Ronai, Ze'ev
发表日期：2007
文献求助 收藏

Human Cdc34 employs distinct sites to coordinate attachment of ubiquitin to a substrate and assembly of polyubiquitin chains

人源Cdc34利用不同的位点来协调泛素与底物的结合以及多聚泛素链的组装。

期刊:Molecular and Cellular Biology
影响因子:2.7
doi:10.1128/MCB.00812-07
Gazdoiu, Stefan; Yamoah, Kosj; Wu, Kenneth; Pan, Zhen-Qiang
Human
发表日期：2007
文献求助 收藏