Ivacaftor, a CFTR potentiator, synergizes with osimertinib against acquired resistance to osimertinib in NSCLC by regulating CFTR-PTEN-AKT axis.
CFTR 增强剂 Ivacaftor 通过调节 CFTR-PTEN-AKT 轴,与奥希替尼协同作用,对抗非小细胞肺癌中对奥希替尼的获得性耐药性
期刊:Acta Pharmacologica Sinica
影响因子:8.4
doi:10.1038/s41401-024-01427-0
Li Yue-Kang, Ge Fu-Jing, Liu Xiang-Ning, Zeng Chen-Ming, Qian Mei-Jia, Li Yong-Hao, Zheng Ming-Ming, Qu Jing-Jing, Fang Liang-Jie, Lu Jin-Jian, Yang Bo, He Qiao-Jun, Zhou Jian-Ya, Zhu Hong