日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

PRMT1依赖的RNA代谢和DNA损伤反应调控维持胰腺导管腺癌

Virginia Giuliani,Meredith A Miller #,Chiu-Yi Liu #,Stella R Hartono #,Caleb A Class,Christopher A Bristow,Erika Suzuki,Lionel A Sanz,Guang Gao,Jason P Gay,Ningping Feng,Johnathon L Rose,Hideo Tomihara,Joseph R Daniele,Michael D Peoples,Jennifer P Bardenhagen,Mary K Geck Do,Qing E Chang,Bhavatarini Vangamudi,Christopher Vellano,Haoqiang Ying,Angela K Deem,Kim-Anh Do,Giannicola Genovese,Joseph R Marszalek,Jeffrey J Kovacs,Michael Kim,Jason B Fleming,Ernesto Guccione,Andrea Viale,Anirban Maitra,M Emilia Di Francesco,Timothy A Yap,Philip Jones,Giulio Draetta,Alessandro Carugo,Frederic Chedin,Timothy P Heffernan

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties

发现具有优异药代动力学和物理化学性质的临床阶段选择性谷氨酰胺酶-1 (GLS-1) 抑制剂 IPN60090

Michael J Soth, Kang Le, Maria Emilia Di Francesco, Matthew M Hamilton, Gang Liu, Jason P Burke, Chris L Carroll, Jeffrey J Kovacs, Jennifer P Bardenhagen, Christopher A Bristow, Mario Cardozo, Barbara Czako, Elisa de Stanchina, Ningping Feng, Jill R Garvey, Jason P Gay, Mary K Geck Do, Jennifer Gre

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

功能基因组学揭示磷酸葡萄糖酸脱氢酶与氧化磷酸化之间的合成致死性

Yuting Sun, Madhavi Bandi, Timothy Lofton, Melinda Smith, Christopher A Bristow, Alessandro Carugo, Norma Rogers, Paul Leonard, Qing Chang, Robert Mullinax, Jing Han, Xi Shi, Sahil Seth, Brooke A Meyers, Meredith Miller, Lili Miao, Xiaoyan Ma, Ningping Feng, Virginia Giuliani, Mary Geck Do, Barbara

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

基于结构的IACS-9571设计:一种选择性高亲和力双重TRIM24-BRPF1溴结构域抑制剂

Palmer, Wylie S; Poncet-Montange, Guillaume; Liu, Gang; Petrocchi, Alessia; Reyna, Naphtali; Subramanian, Govindan; Theroff, Jay; Yau, Anne; Kost-Alimova, Maria; Bardenhagen, Jennifer P; Leo, Elisabetta; Shepard, Hannah E; Tieu, Trang N; Shi, Xi; Zhan, Yanai; Zhao, Shuping; Barton, Michelle C; Draetta, Giulio; Toniatti, Carlo; Jones, Philip; Geck Do, Mary; Andersen, Jannik N

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2

观察到的溴结构域柔性揭示了ATAD2与组蛋白肽和小分子配体相容的形式

Poncet-Montange, Guillaume; Zhan, Yanai; Bardenhagen, Jennifer P; Petrocchi, Alessia; Leo, Elisabetta; Shi, Xi; Lee, Gilbert R 4th; Leonard, Paul G; Geck Do, Mary K; Cardozo, Mario G; Andersen, Jannik N; Palmer, Wylie S; Jones, Philip; Ladbury, John E