Mithramycin alters EWS::FLI1 DNA binding and RNA polymerase II processivity to inhibit nascent transcription
米索霉素通过改变 EWS::FLI1 与 DNA 的结合以及 RNA 聚合酶 II 的加工能力来抑制新生转录。
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-69488-9
Kaufman, Rebecca; Flores, Guillermo; Boguslawski, Elissa A; Kinn-Gurzo, Seneca; Chassé, Maggie; Beddows, Ian; Adams, Marie; Stout, Matthew C; Gaetano, Lauren; Lopez, Raphael; Veluvolu, Sridhar; Fuller, Andrew; Kitchen-Goosen, Susan M; Tolstyka, Zachary P; Gedminas, Jenna M; Grohar, Patrick J
