日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Uncovering the genomic complexity of PAX5 intragenic tandem multiplication via long-read and short-read sequencing

利用长读长和短读长测序揭示PAX5基因内串联重复的基因组复杂性

Liu, Yanling; Ju, Bensheng; Dong, Li; Loyd, Melanie; Brady, Samuel W; Ries, Rhonda; Feng, Yuan; Mulder, Heather; Plyler, Emily; Deardorff, Christian; McBride, Andrea; Jones, Tyler; Eckert, Alexis; Kolekar, Pandurang; Fan, Li; Li, Hanxia; Briviba, Monta; Zhao, Huanbin; Bennett, Declan; Neale, Geoff; Chang, Ti-Cheng; Chen, Wenan; Pounds, Stanley; Wu, Gang; Mullighan, Charles; Geeleher, Paul; Ji, Lingyun; Yang, Jun J; Meshinchi, Soheil; Brown, Patrick A; Carroll, William L; Zhang, Jinghui; Loh, Mignon L; Easton, John; Ma, Xiaotu

Tabular foundation model predicts alternative lengthening of telomeres (ALT) and identifies SMARCAL1 as a target in ALT-driven cancers

表格基础模型预测端粒替代延长(ALT),并将SMARCAL1确定为ALT驱动型癌症的靶点

Bennett, D; Wierdl, M; Chakraborty, S; Johnson, J D; Akingbehin, V; Estevez-Prado, D; Feng, Y; Morsby, J J; Harper, J; Mohammad Nezhady, M A; Pan, M; Ocasio-Martinez, N; Catlett, J L; Nations, T B; Dharia, N V; Robichaud, A; Herman, A; Zhang, S; Kelly, J; Steele, J; Rusch, M; Wienand, K; Campbell, C D; Alexe, G; Vazquez, F; Getz, G; Roberts, Cwm; Mullighan, C G; Sweet-Cordero, E A; Reynolds, C P; Koneru, B; Shelat, A A; Durbin, A D; Bernstein, E; Ma, X; Stegmaier, K; Geeleher, P; Guenther, L M

Venetoclax plus gilteritinib is effective in preclinical models of FLT3-mutant BCL11B-a lineage-ambiguous leukemia

Venetoclax联合gilteritinib在FLT3突变型BCL11B-a谱系不明确白血病的临床前模型中有效。

Lindsey E Montefiori,Ilaria Iacobucci,Qingsong Gao,Jamila Moore,William C Wright,Huimei Wei,Pradyumna Baviskar,Surbhi Sona,Hongjian Jin,Amit Budhraja,Josi Lott,Qi Zhang Tatarata,Zhongshan Cheng,Tanya Khan,Emily A Backhaus Wagner,Melissa Johnson,Cyrus M Mehr,Burgess Freeman,Laura Janke,Torsten Haferlach,Paul Geeleher,Paul E Mead,Marina Konopleva,Joseph T Opferman,Charles G Mullighan

Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus

前药氟苯尼考胺通过固有耐药性激活,靶向脓肿分枝杆菌。

Phelps, Gregory A; Kurt, Sinem; Jenner, Alexander R; Anderson, Shelby M; Jayasinghe, Thalina D; Griffith, Elizabeth C; Thompson, Carl W; Yang, Lei; Wicki, Basil; Bright, Frederick K; Loudon, Victoria; Wright, William C; Srivastava, Ashish; Singh, Amarinder; Thalluri, Bhargavi; Park, Hyunseo; Lee, Robin B; Wright, Anna K; Grant-Chapman, Oliver; Conner, Daryl K; Troyer, Brennen T; Iverson, Amy; Ochoado, Jason; Pagala, Vishwajeeth R; Wu, Long; Byrum, Stephanie; Fu, Yingxue; Yuan, Zu-Fei; High, Anthony A; Schulthess, Bettina; Rosch, Jason W; Geeleher, Paul; Hobbie, Sven N; Boeck, Lucas; Meibohm, Bernd; Obregon-Henao, Andres; Sander, Peter; Lee, Richard E

An open-source screening platform accelerates discovery of drug combinations

开源筛选平台加速药物组合的发现

Wright, William C; Pan, Min; Phelps, Gregory A; Low, Jonathan; Currier, Duane; Sanjali, Ankita; Trotter, Marlon; Hwang, Jihye; Chapple, Richard H; Liu, Xueying; Bennett, Declan; Zhang, Yinwen; Lee, Richard E; Chen, Taosheng; Geeleher, Paul

CSI-GEP: A GPU-based unsupervised machine learning approach for recovering gene expression programs in atlas-scale single-cell RNA-seq data

CSI-GEP:一种基于GPU的无监督机器学习方法,用于从图谱规模的单细胞RNA测序数据中恢复基因表达程序。

Liu, Xueying; Chapple, Richard H; Bennett, Declan; Wright, William C; Sanjali, Ankita; Culp, Erielle; Zhang, Yinwen; Pan, Min; Geeleher, Paul

A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity

神经母细胞瘤的空间细胞图谱揭示了肿瘤异质性的发育、表观遗传和空间轴

Patel, Anand G; Ashenberg, Orr; Collins, Natalie B; Segerstolpe, Åsa; Jiang, Sizun; Slyper, Michal; Huang, Xin; Caraccio, Chiara; Jin, Hongjian; Sheppard, Heather; Xu, Ke; Chang, Ti-Cheng; Orr, Brent A; Shirinifard, Abbas; Chapple, Richard H; Shen, Amber; Clay, Michael R; Tatevossian, Ruth G; Reilly, Colleen; Patel, Jaimin; Lupo, Marybeth; Cline, Cynthia; Dionne, Danielle; Porter, Caroline B M; Waldman, Julia; Bai, Yunhao; Zhu, Bokai; Barrera, Irving; Murray, Evan; Vigneau, Sébastien; Napolitano, Sara; Wakiro, Isaac; Wu, Jingyi; Grimaldi, Grace; Dellostritto, Laura; Helvie, Karla; Rotem, Asaf; Lako, Ana; Cullen, Nicole; Pfaff, Kathleen L; Karlström, Åsa; Jané-Valbuena, Judit; Todres, Ellen; Thorner, Aaron; Geeleher, Paul; Rodig, Scott J; Zhou, Xin; Stewart, Elizabeth; Johnson, Bruce E; Wu, Gang; Chen, Fei; Yu, Jiyang; Goltsev, Yury; Nolan, Garry P; Rozenblatt-Rosen, Orit; Regev, Aviv; Dyer, Michael A

Cell type identification in spatial transcriptomics data can be improved by leveraging cell-type-informative paired tissue images using a Bayesian probabilistic model

利用贝叶斯概率模型,结合包含细胞类型信息的配对组织图像,可以提高空间转录组学数据中细胞类型的识别精度。

Zubair, Asif; Chapple, Richard H; Natarajan, Sivaraman; Wright, William C; Pan, Min; Lee, Hyeong-Min; Tillman, Heather; Easton, John; Geeleher, Paul

Random-effects meta-analysis of effect sizes as a unified framework for gene set analysis

随机效应效应量荟萃分析作为基因集分析的统一框架

Makrooni, Mohammad A; O'Shea, Dónal; Geeleher, Paul; Seoighe, Cathal

Exploring the Link between the Germline and Somatic Genome in Cancer

探索癌症中生殖细胞系和体细胞基因组之间的联系

Geeleher, Paul; Huang, R Stephanie