日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP

基于结构的环二核苷酸磷酸二酯酶 ENPP1 和 CdnP 抑制剂的虚拟筛选和体外验证

Akshay Rohilla #, Alok Kumar Singh #, Benjamin Koleske, Geetha Srikrishna, William R Bishai

Inhibition of host PARP1 contributes to the anti-inflammatory and antitubercular activity of pyrazinamide

抑制宿主PARP1有助于吡嗪酰胺发挥抗炎和抗结核活性

Stefanie Krug, Manish Gupta, Pankaj Kumar, Laine Feller, Elizabeth A Ihms, Bong Gu Kang, Geetha Srikrishna, Ted M Dawson, Valina L Dawson, William R Bishai

MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival

结核分枝杆菌激活 MDA5 RNA 传感通路促进先天免疫颠覆和病原体存活

C Korin Bullen, Alok K Singh, Stefanie Krug, Shichun Lun, Preeti Thakur, Geetha Srikrishna, William R Bishai

Intravenous BCG vaccination reduces SARS-CoV-2 severity and promotes extensive reprogramming of lung immune cells

静脉注射卡介苗可降低SARS-CoV-2感染的严重程度,并促进肺部免疫细胞的广泛重编程。

Alok K Singh ,Rulin Wang ,Kara A Lombardo ,Monali Praharaj ,C Korin Bullen ,Peter Um ,Manish Gupta ,Geetha Srikrishna ,Stephanie Davis ,Oliver Komm ,Peter B Illei ,Alvaro A Ordonez ,Melissa Bahr ,Joy Huang ,Anuj Gupta ,Kevin J Psoter ,Patrick S Creisher ,Maggie Li ,Andrew Pekosz ,Sabra L Klein ,Sanjay K Jain ,Trinity J Bivalacqua ,Srinivasan Yegnasubramanian ,William R Bishai

Improved bladder cancer antitumor efficacy with a recombinant BCG that releases a STING agonist

利用释放 STING 激动剂的重组 BCG 提高膀胱癌抗肿瘤疗效

Peter K Um, Monali Praharaj, Kara A Lombardo, Takahiro Yoshida, Andres Matoso, Alex S Baras, Liang Zhao, Geetha Srikrishna, Joy Huang, Pankaj Prasad, Max Kates, David McConkey, Drew M Pardoll, William R Bishai, Trinity J Bivalacqua

Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer

经过改造、过表达环状二磷酸腺苷(c-di-AMP)的卡介苗可增强训练免疫力,并提高对膀胱癌的疗效。

Alok Kumar Singh ,Monali Praharaj ,Kara A Lombardo ,Takahiro Yoshida ,Andres Matoso ,Alex S Baras ,Liang Zhao ,Geetha Srikrishna ,Joy Huang ,Pankaj Prasad ,Jonathan D Powell ,Max Kates ,David McConkey ,Drew M Pardoll ,William R Bishai ,Trinity J Bivalacqua

The calcium-binding proteins S100A8 and S100A9 initiate the early inflammatory program in injured peripheral nerves

钙结合蛋白 S100A8 和 S100A9 启动受损周围神经的早期炎症程序

Andrei V Chernov, Jennifer Dolkas, Khang Hoang, Mila Angert, Geetha Srikrishna, Thomas Vogl, Svetlana Baranovskaya, Alex Y Strongin, Veronica I Shubayev

N-glycosylation deficiency reduces ICAM-1 induction and impairs inflammatory response

N-糖基化缺陷会降低 ICAM-1 诱导并损害炎症反应

Ping He, Geetha Srikrishna, Hudson H Freeze

Proinflammatory S100 proteins regulate the accumulation of myeloid-derived suppressor cells

促炎性 S100 蛋白调节髓系抑制细胞的积累

Pratima Sinha, Chinonyerem Okoro, Dirk Foell, Hudson H Freeze, Suzanne Ostrand-Rosenberg, Geetha Srikrishna