Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors
全基因组合成致死筛选揭示了新型 CAIX-NFS1/xCT 轴作为缺氧实体肿瘤的可靶向弱点
期刊:Science Advances
影响因子:11.7
doi:10.1126/sciadv.abj0364
Shawn C Chafe, Frederick S Vizeacoumar, Geetha Venkateswaran, Oksana Nemirovsky, Shannon Awrey, Wells S Brown, Paul C McDonald, Fabrizio Carta, Andrew Metcalfe, Joanna M Karasinska, Ling Huang, Senthil K Muthuswamy, David F Schaeffer, Daniel J Renouf, Claudiu T Supuran, Franco J Vizeacoumar, Shoukat
