日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Beyond spirometry: understanding COPD origins to support a new diagnostic approach

超越肺功能测定:了解慢性阻塞性肺疾病的病因以支持新的诊断方法

Morelli, Tommaso; Geeves, Madison E; Mohammed, Ahmed; Spalluto, Cosma Mirella; Ackland, Jodie; Freeman, Anna; Ullah, Farhan; Weeks, Jake; Page, Lee; Kong, Alex; Welham, Benjamin; Tarcan, Arda; Purcell, Martha; Simms, Claire; Staples, Karl J; Watson, Alastair; Wilkinson, Tom Ma

Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model

猪心室肌和人干细胞衍生心肌细胞模型中β-肌球蛋白R403Q突变导致收缩功能改变的分子机制

Steczina, Sonette; Mohran, Saffie; Childers, Matthew C; McMillen, Timothy S; Naim, Ateeqa; Pilagov, Matvey; Dente, Marica; Kooiker, Kristina B; Mandrycky, Christian; Tawde, Khushi; Hesson, Jennifer; Zhao, Jing; Mathieu, Julie; Pioner, J Manuel; Geeves, Michael A; Ma, Weikang; Moussavi-Harami, Farid; Kad, Neil M; Regnier, Michael

Extracellular vesicle-linked vitamin B12 acquisition via novel binding proteins in Bacteroides thetaiotaomicron

拟杆菌属(Bacteroides thetaiotaomicron)中通过新型结合蛋白获取胞外囊泡连接的维生素B12

Juodeikis, Rokas; Ulrich, Robert; Clarke, Charlea; Banasik, Michal; Deery, Evelyne; Saalbach, Gerhard; Kräutler, Bernhard; Carding, Simon R; Geeves, Michael A; Pickersgill, Richard W; Warren, Martin J

Rapid changes in hydrostatic pressure as a probe for correlating function of purified proteins with their measured activity in living cells

利用静水压的快速变化作为探针,可将纯化蛋白质的功能与其在活细胞中测得的活性联系起来。

Mulvihill, Daniel P; Geeves, Michael A

Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity.

从空间角度解析猪和人肌原纤维中 cMyBP-C 磷酸化和单倍体不足如何影响 β-心肌肌球蛋白活性

Pilagov Matvey, Steczina Sonette, Naim Ateeqa, Regnier Michael, Geeves Michael A, Kad Neil M

Direct measurement of mavacamten and deoxyATP perturbation of the SRX/DRX ratio in porcine cardiac myofibrils using a simple, accessible and multiplexed approach

采用简单、易行且可多重检测的方法直接测量猪心肌原纤维中马伐卡明和脱氧ATP对SRX/DRX比值的影响

Pilagov, Matvey; Naim, Ateeqa; Campbell, Kenneth S; Kampourakis, Thomas; Geeves, Michael A; Kad, Neil M

Motor domain phosphorylation increases nucleotide exchange and turns MYO6 into a faster and stronger motor

运动域磷酸化增加核苷酸交换,使 MYO6 变成更快、更强的运动细胞

Janeska J de Jonge #, Andreas Graw #, Vasileios Kargas, Christopher Batters, Antonino F Montanarella, Tom O'Loughlin, Chloe Johnson, Susan D Arden, Alan J Warren, Michael A Geeves, John Kendrick-Jones, Nathan R Zaccai, Markus Kröss, Claudia Veigel, Folma Buss

MYBPC3-c.772G>A mutation results in haploinsufficiency and altered myosin cycling kinetics in a patient induced stem cell derived cardiomyocyte model of hypertrophic cardiomyopathy

MYBPC3-c.772G>A 突变导致肥厚型心肌病患者诱导干细胞衍生心肌细胞模型中单倍体功能不全和肌球蛋白循环动力学改变。

Steczina, Sonette; Mohran, Saffie; Bailey, Logan R J; McMillen, Timothy S; Kooiker, Kristina B; Wood, Neil B; Davis, Jennifer; Previs, Michael J; Olivotto, Iacopo; Pioner, Josè Manuel; Geeves, Michael A; Poggesi, Corrado; Regnier, Michael

The biochemically defined super relaxed state of myosin-A paradox

生化定义的肌球蛋白超松弛状态-A悖论

Saffie Mohran, Kristina Kooiker, Max Mahoney-Schaefer, Christian Mandrycky, Kerry Kao, An-Yue Tu, Jeremy Freeman, Farid Moussavi-Harami, Michael Geeves, Michael Regnier

Interacting myosin head dynamics and their modification by 2'-deoxy-ADP

肌球蛋白头部相互作用动力学及其受2'-脱氧-ADP的修饰

Childers, Matthew Carter; Geeves, Michael A; Regnier, Michael