日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model

猪心室肌和人干细胞衍生心肌细胞模型中β-肌球蛋白R403Q突变导致收缩功能改变的分子机制

Steczina, Sonette; Mohran, Saffie; Childers, Matthew C; McMillen, Timothy S; Naim, Ateeqa; Pilagov, Matvey; Dente, Marica; Kooiker, Kristina B; Mandrycky, Christian; Tawde, Khushi; Hesson, Jennifer; Zhao, Jing; Mathieu, Julie; Pioner, J Manuel; Geeves, Michael A; Ma, Weikang; Moussavi-Harami, Farid; Kad, Neil M; Regnier, Michael

Extracellular vesicle-linked vitamin B12 acquisition via novel binding proteins in Bacteroides thetaiotaomicron

拟杆菌属(Bacteroides thetaiotaomicron)中通过新型结合蛋白获取胞外囊泡连接的维生素B12

Juodeikis, Rokas; Ulrich, Robert; Clarke, Charlea; Banasik, Michal; Deery, Evelyne; Saalbach, Gerhard; Kräutler, Bernhard; Carding, Simon R; Geeves, Michael A; Pickersgill, Richard W; Warren, Martin J

Rapid changes in hydrostatic pressure as a probe for correlating function of purified proteins with their measured activity in living cells

利用静水压的快速变化作为探针,可将纯化蛋白质的功能与其在活细胞中测得的活性联系起来。

Mulvihill, Daniel P; Geeves, Michael A

Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity.

从空间角度解析猪和人肌原纤维中 cMyBP-C 磷酸化和单倍体不足如何影响 β-心肌肌球蛋白活性

Pilagov Matvey, Steczina Sonette, Naim Ateeqa, Regnier Michael, Geeves Michael A, Kad Neil M

Direct measurement of mavacamten and deoxyATP perturbation of the SRX/DRX ratio in porcine cardiac myofibrils using a simple, accessible and multiplexed approach

采用简单、易行且可多重检测的方法直接测量猪心肌原纤维中马伐卡明和脱氧ATP对SRX/DRX比值的影响

Pilagov, Matvey; Naim, Ateeqa; Campbell, Kenneth S; Kampourakis, Thomas; Geeves, Michael A; Kad, Neil M

Conserved Phosphorylation of the Myosin1e TH1 Domain Impacts Membrane Association and Function in Yeast and Worms

肌球蛋白1e TH1结构域的保守磷酸化影响酵母和线虫中的膜结合和功能

Brooker, Holly R; Baker, Karen; Ezcurra, Marina; Laissue, Philippe P; Wang, Lin; Geeves, Michael A; Tullet, Jennifer M; Mulvihill, Daniel P

MYBPC3-c.772G>A mutation results in haploinsufficiency and altered myosin cycling kinetics in a patient induced stem cell derived cardiomyocyte model of hypertrophic cardiomyopathy

MYBPC3-c.772G>A 突变导致肥厚型心肌病患者诱导干细胞衍生心肌细胞模型中单倍体功能不全和肌球蛋白循环动力学改变。

Steczina, Sonette; Mohran, Saffie; Bailey, Logan R J; McMillen, Timothy S; Kooiker, Kristina B; Wood, Neil B; Davis, Jennifer; Previs, Michael J; Olivotto, Iacopo; Pioner, Josè Manuel; Geeves, Michael A; Poggesi, Corrado; Regnier, Michael

Interacting myosin head dynamics and their modification by 2'-deoxy-ADP

肌球蛋白头部相互作用动力学及其受2'-脱氧-ADP的修饰

Childers, Matthew Carter; Geeves, Michael A; Regnier, Michael

Myosin's powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin

肌球蛋白的动力冲程转变定义了心肌细丝原肌球蛋白的原子尺度运动。

Rynkiewicz, Michael J; Childers, Matthew C; Karpicheva, Olga E; Regnier, Michael; Geeves, Michael A; Lehman, William

Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle

Danicamtiv 增加心肌肌球蛋白募集并改变横桥循环

Kooiker, Kristina B; Mohran, Saffie; Turner, Kyrah L; Ma, Weikang; Martinson, Amy; Flint, Galina; Qi, Lin; Gao, Chengqian; Zheng, Yahan; McMillen, Timothy S; Mandrycky, Christian; Mahoney-Schaefer, Max; Freeman, Jeremy C; Costales Arenas, Elijah Gabriela; Tu, An-Yu; Irving, Thomas C; Geeves, Michael A; Tanner, Bertrand C W; Regnier, Michael; Davis, Jennifer; Moussavi-Harami, Farid