日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease.

在 LRRK2-帕金森病模型中,溶酶体 TPC2 通道会破坏 Ca2+ 内流和多巴胺能功能

Gregori Martina, Pereira Gustavo J S, Allen Robert, West Nicholas, Chau Kai-Yin, Cai Xinjiang, Bostock Matthew P, Bolsover Stephen R, Keller Marco, Lee Chiao-Yin, Lei Si Hang, Harvey Kirsten, Bracher Franz, Grimm Christian, Hasan Gaiti, Gegg Matthew E, Schapira Anthony H V, Sweeney Sean T, Patel Sandip

Loss of the auxiliary α(2)δ(1) voltage-sensitive calcium channel subunit impairs bone formation and anabolic responses to mechanical loading

辅助性α(2)δ(1)电压敏感性钙通道亚基的缺失会损害骨骼形成和对机械负荷的合成代谢反应。

Kelly, Madison M; Sharma, Karan; Wright, Christian S; Yi, Xin; Reyes Fernandez, Perla C; Gegg, Aaron T; Gorrell, Taylor A; Noonan, Megan L; Baghdady, Ahmed; Sieger, Jacob A; Dolphin, Annette C; Warden, Stuart J; Deosthale, Padmini; Plotkin, Lilian I; Sankar, Uma; Hum, Julia M; Robling, Alexander G; Farach-Carson, Mary C; Thompson, William R

α-Synuclein expression in response to bacterial ligands and metabolites in gut enteroendocrine cells: an in vitro proof of concept study

肠道肠内分泌细胞中细菌配体和代谢物的 α-突触核蛋白表达:一项体外概念验证研究

Michael J Hurley, Elisa Menozzi, Sofia Koletsi, Rachel Bates, Matthew E Gegg, Kai-Yin Chau, Hervé M Blottière, Jane Macnaughtan, Anthony H V Schapira

Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency

葡萄糖脑苷脂酶和酸性鞘磷脂酶联合缺乏症的意外表型和分子变化

Marcus Keatinge, Matthew E Gegg, Lisa Watson, Heather Mortiboys, Nan Li, Mark Dunning, Deepak Ailani, Hai Bui, Astrid van Rens, Dirk J Lefeber, Anthony H V Schapira, Ryan B MacDonald, Oliver Bandmann

The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines

GBA 变体 E326K 与人类细胞系中的 α-突触核蛋白聚集和脂滴积累有关

Laura J Smith ,Magdalena M Bolsinger ,Kai-Yin Chau ,Matthew E Gegg ,Anthony H V Schapira

Clinical factors associated with need for neurosurgical care in young children with imaging for macrocephaly: a case control study

影像学检查发现巨头畸形的幼儿需要神经外科治疗的临床因素:一项病例对照研究

Rohde, Jessica F; Campbell, Jeffrey; Barbera, Julie; Taylor, Elena; Ramachandra, Ashok; Gegg, Christopher; Scherer, Andrea; Piatt, Joseph

Ambroxol reverses tau and α-synuclein accumulation in a cholinergic N370S GBA1 mutation model

氨溴索可逆转胆碱能 N370S GBA1 突变模型中的 tau 蛋白和 α-突触核蛋白积累

Yang, Shi Yu; Taanman, Jan-Willem; Gegg, Matthew; Schapira, Anthony H V

A Standardized Investigational Ki-67 Immunohistochemistry Assay Used to Assess High-Risk Early Breast Cancer Patients in the monarchE Phase 3 Clinical Study Identifies a Population With Greater Risk of Disease Recurrence When Treated With Endocrine Therapy Alone

在monarchE III期临床研究中,一项用于评估高危早期乳腺癌患者的标准化研究性Ki-67免疫组化检测方法,识别出仅接受内分泌治疗时疾病复发风险更高的患者群体。

Polewski, Monika D; Nielsen, Gitte B; Gu, Ying; Weaver, Aaron T; Gegg, Gavin; Tabuena-Frolli, Siena; Cajaiba, Mariana; Hanks, Debra; Method, Michael; Press, Michael F; Gottstein, Claudia; Gruver, Aaron M

Mixed Composition Microribbon Hydrogels Induce Rapid and Synergistic Cartilage Regeneration by Mesenchymal Stem Cells in 3D via Paracrine Signaling Exchange

混合成分微带水凝胶通过旁分泌信号交换诱导间充质干细胞在三维空间中快速协同地再生软骨。

Gegg, Courtney; Tong, Xinming; Yang, Fan

Nanoparticle-Mediated TGF-β Release from Microribbon-Based Hydrogels Accelerates Stem Cell-Based Cartilage Formation In Vivo

纳米颗粒介导的TGF-β从微带基水凝胶中释放可加速体内干细胞软骨形成

Barati, Danial; Gegg, Courtney; Yang, Fan