日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1.

泛素连接酶 HUWE1 对药物样小分子进行选择性泛素化

Orth Barbara, Pohl Pavel, Aust Florian, Ji Yanlong, Seenivasan Ayshwarya, Dybkov Olexandr, Liang Xiaojun Julia, Bock Lars, Leidner Florian, Levantovsky Sophie, Schardey Patrick, Sander Pascal, Disch Nathanael J, Trautz Masanja L, Mizi Athanasia, Papantonis Argyris, Lenz Christof, Grubmüller Helmut, Steinchen Wieland, Behrends Christian, Urlaub Henning, Gehringer Matthias, Lorenz Sonja

Screening of Covalent Kinase Inhibitors Yields Hits for Cysteine Protease USP7 / HAUSP

共价激酶抑制剂筛选发现半胱氨酸蛋白酶USP7/HAUSP的有效抑制剂

Ernst, Larissa N; Jaag, Simon J; Wydra, Valentin R; Masberg, Benedikt; Knappe, Cornelius; Gerstenecker, Stefan; Serafim, Ricardo A M; Liang, Xiaojun Julia; Seidler, Nico J; Lämmerhofer, Michael; Gehringer, Matthias; Boeckler, Frank M

High-Quality In Vivo Chemical Probes for Protein Kinases Disclosed in 2024

2024年公开的用于蛋白激酶的高质量体内化学探针

Serafim, Ricardo A M; Gehringer, Matthias

A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2

剧情出现转折:从JAK3中酪氨酸的共价靶向转变为MK2中赖氨酸的共价靶向。

Hillebrand, Laura; Wang, Guiqun; Rasch, Alexander; Masberg, Benedikt; Chaikuad, Apirat; Kronenberger, Thales; Günther, Ellen; Forster, Michael; Poso, Antti; Lämmerhofer, Michael; Laufer, Stefan A; Knapp, Stefan; Gehringer, Matthias

Design, Synthesis, and Molecular Evaluation of S(N)Ar-Reactive N-(6-Fluoro-3-Nitropyridin-2-yl)Isoquinolin-3-Amines as Covalent USP7 Inhibitors Reveals an Unconventional Binding Mode

S(N)Ar反应性N-(6-氟-3-硝基吡啶-2-基)异喹啉-3-胺类化合物作为共价USP7抑制剂的设计、合成和分子评价揭示了一种非常规的结合模式

Ernst, Larissa N; Stahlecker, Jason; Mier, Finn; Serafim, Ricardo A M; Wydra, Valentin R; Masberg, Benedikt; Jaag, Simon J; Knappe, Cornelius; Lämmerhofer, Michael; Stehle, Thilo; Gehringer, Matthias; Boeckler, Frank M

Go for Gold: Development of a Scalable Synthesis of [1-(Ethoxycarbonyl)cyclopropyl] Triphenylphosphonium Tetrafluoroborate, a Key Reagent to Explore Covalent Monopolar Spindle 1 Inhibitors

追求卓越:开发可规模化合成[1-(乙氧羰基)环丙基]三苯基膦四氟硼酸盐的方法,该方法是探索共价单极纺锤体1抑制剂的关键试剂

Rebhan, Leon; Fürst, Rebekka; Schollmeyer, Dieter; Serafim, Ricardo A M; Gehringer, Matthias

Nocathioamides, Uncovered by a Tunable Metabologenomic Approach, Define a Novel Class of Chimeric Lanthipeptides

通过可调控代谢基因组学方法发现的诺卡硫酰胺,定义了一类新型嵌合羊毛硫肽。

Saad, Hamada; Aziz, Saefuddin; Gehringer, Matthias; Kramer, Markus; Straetener, Jan; Berscheid, Anne; Brötz-Oesterhelt, Heike; Gross, Harald

An Antigen Capture Assay for the Detection of Mycolactone, the Polyketide Toxin of Mycobacterium ulcerans

用于检测溃疡分枝杆菌聚酮毒素——分枝杆菌内酯的抗原捕获分析

Warryn, Louisa; Dangy, Jean-Pierre; Gersbach, Philipp; Gehringer, Matthias; Altmann, Karl-Heinz; Pluschke, Gerd

Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK

发现一类新型共价双重抑制剂,靶向蛋白激酶BMX和BTK

Forster, Michael; Liang, Xiaojun Julia; Schröder, Martin; Gerstenecker, Stefan; Chaikuad, Apirat; Knapp, Stefan; Laufer, Stefan; Gehringer, Matthias

Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans

开发用于定量检测溃疡分枝杆菌细胞毒性大环内酯毒素——分枝杆菌内酯的ELISA方法

Warryn, Louisa; Dangy, Jean-Pierre; Gersbach, Philipp; Gehringer, Matthias; Schäfer, Anja; Ruf, Marie-Thérèse; Ruggli, Nicolas; Altmann, Karl-Heinz; Pluschke, Gerd