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Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites

Mia2（一种定位于内质网出口位点的肝脏蛋白）发生突变的小鼠体内胆固醇和甘油三酯降低

期刊:Journal of Lipid Research

影响因子:5

doi:10.1194/jlr.M017277

Jeffrey L Pitman, David J Bonnet, Linda K Curtiss, Nicholas Gekakis

代谢

发表日期：2011

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A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice

Sec61alpha1的点突变导致小鼠患上糖尿病和肝脂肪变性

期刊:Diabetes

影响因子:6.2

doi:10.2337/db08-1362

David J Lloyd, Matthew C Wheeler, Nicholas Gekakis

Loss-of-function mutation in myostatin reduces tumor necrosis factor alpha production and protects liver against obesity-induced insulin resistance

肌生长抑制素功能丧失突变可减少肿瘤坏死因子 α 的产生并保护肝脏免受肥胖引起的胰岛素抵抗

期刊:Diabetes

影响因子:6.2

doi:10.2337/db08-0245

Jason J Wilkes, David J Lloyd, Nick Gekakis

Negative regulators of insulin signaling revealed in a genome-wide functional screen

全基因组功能筛选揭示胰岛素信号的负调节剂

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0006871

Shih-Min A Huang, Michael K Hancock, Jeffrey L Pitman, Anthony P Orth, Nicholas Gekakis

信号转导

发表日期：2009

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A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence

Alström综合征蛋白alms1在肾脏纤毛发生和细胞静止中的作用

期刊:PLoS Genetics

影响因子:3.7

doi:10.1371/journal.pgen.0030008

Li, Guochun; Vega, Raquel; Nelms, Keats; Gekakis, Nicholas; Goodnow, Christopher; McNamara, Peter; Wu, Hua; Hong, Nancy A; Glynne, Richard

细胞生物学

发表日期：2007

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Diabetes insipidus in mice with a mutation in aquaporin-2

水通道蛋白2基因突变小鼠的尿崩症

期刊:

影响因子:

doi:10.1371/journal.pgen.0010020

Lloyd, David J; Hall, Frank Wesley; Tarantino, Lisa M; Gekakis, Nicholas

发表日期：2005

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Hsp90 modulates PPARγ activity in a mouse model of nonalcoholic fatty liver disease

Hsp90在非酒精性脂肪肝疾病小鼠模型中调节PPARγ活性

Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function

肥胖突变体 PC1/3 N222D 的运输缺陷导致功能丧失

A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity

腺苷酸环化酶3的功能获得性突变可保护小鼠免受饮食诱导的肥胖症的影响

Reduced cholesterol and triglycerides in mice with a mutation in Mia2, a liver protein that localizes to ER exit sites

Mia2（一种定位于内质网出口位点的肝脏蛋白）发生突变的小鼠体内胆固醇和甘油三酯降低

A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice

Sec61alpha1的点突变导致小鼠患上糖尿病和肝脂肪变性

Loss-of-function mutation in myostatin reduces tumor necrosis factor alpha production and protects liver against obesity-induced insulin resistance

肌生长抑制素功能丧失突变可减少肿瘤坏死因子 α 的产生并保护肝脏免受肥胖引起的胰岛素抵抗

Negative regulators of insulin signaling revealed in a genome-wide functional screen

全基因组功能筛选揭示胰岛素信号的负调节剂

A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence

Alström综合征蛋白alms1在肾脏纤毛发生和细胞静止中的作用

Diabetes insipidus in mice with a mutation in aquaporin-2

水通道蛋白2基因突变小鼠的尿崩症