日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure

体外和体内评估小分子APJ（Apelin受体）激动剂BMS-986224作为心力衰竭潜在治疗方法

期刊:Circulation-Heart Failure
影响因子:8.4
doi:10.1161/CIRCHEARTFAILURE.120.007351
Gargalovic, Peter; Wong, Pancras; Onorato, Joelle; Finlay, Heather; Wang, Tao; Yan, Mujing; Crain, Earl; St-Onge, Stéphane; Héroux, Madeleine; Bouvier, Michel; Xu, Carrie; Chen, Xue-Qing; Generaux, Claudia; Lawrence, Michael; Wexler, Ruth; Gordon, David
心力衰竭
多发性硬化症
APJ
心血管
信号转导
发表日期：2021
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Identification of 6-Hydroxypyrimidin-4(1H)-one-3-carboxamides as Potent and Orally Active APJ Receptor Agonists

鉴定出 6-羟基嘧啶-4(1H)-酮-3-甲酰胺类化合物为强效口服活性 APJ 受体激动剂

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.1c00385
Pi, Zulan; Johnson, James A; Meng, Wei; Phillips, Monique; Schumacher, William A; Bostwick, Jeffrey S; Gargalovic, Peter S; Onorato, Joelle M; Generaux, Claudia N; Wang, Tao; He, Yan; Gordon, David A; Wexler, Ruth R; Finlay, Heather J
信号转导
APJ
发表日期：2021
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Refining Liver Safety Risk Assessment: Application of Mechanistic Modeling and Serum Biomarkers to Cimaglermin Alfa (GGF2) Clinical Trials

优化肝脏安全性风险评估：将机制模型和血清生物标志物应用于西美格列明α（GGF2）临床试验

期刊:Clinical Pharmacology & Therapeutics
影响因子:5.5
doi:10.1002/cpt.711
Longo, D M; Generaux, G T; Howell, B A; Siler, S Q; Antoine, D J; Button, D; Caggiano, A; Eisen, A; Iaci, J; Stanulis, R; Parry, T; Mosedale, M; Watkins, P B
发表日期：2017
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A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair

基于半生理学的药代动力学建模方法预测抗寄生虫前药/活性代谢物对的剂量-暴露关系

期刊:Drug Metabolism and Disposition
影响因子:4.4
doi:10.1124/dmd.111.040063
Grace Zhixia Yan, Claudia N Generaux, Miyoung Yoon, Rachel B Goldsmith, Richard R Tidwell, James E Hall, Carol A Olson, Harvey J Clewell, Kim L R Brouwer, Mary F Paine
代谢
发表日期：2012
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Use of cassette dosing in sandwich-cultured rat and human hepatocytes to identify drugs that inhibit bile acid transport

在夹层培养的大鼠和人类肝细胞中使用盒式给药来识别抑制胆汁酸转运的药物

期刊:Toxicology in Vitro
影响因子:2.6
doi:10.1016/j.tiv.2009.08.009
Kristina K Wolf, Sapana Vora, Lindsey O Webster, Grant T Generaux, Joseph W Polli, Kim L R Brouwer
细胞生物学
其它细胞
Human
发表日期：2010
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