The hereditary N363K POLE exonuclease mutant extends PPAP tumor spectrum to glioblastomas by causing DNA damage and aneuploidy in addition to increased mismatch mutagenicity
遗传性 N363K POLE 核酸外切酶突变体除了增加错配致突变性外，还会引起 DNA 损伤和非整倍性，从而将 PPAP 肿瘤谱扩展到胶质母细胞瘤
期刊:NAR Cancer
影响因子:3.4
doi:10.1093/narcan/zcad011
Guillaume Labrousse, Pierre Vande Perre, Genis Parra, Marion Jaffrelot, Laura Leroy, Frederic Chibon, Frederic Escudie, Janick Selves, Jean-Sebastien Hoffmann, Rosine Guimbaud, Malik Lutzmann
