日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

From Prompt to Drug: Toward Pharmaceutical Superintelligence

从提示到药物:迈向药物超级智能

Tabana, Yasser; Okoye, Isobel S; Siraki, Arno; Elahi, Shokrollah; Barakat, Khaled H; Zhavoronkov, Alex; Gennert, David; Shi, Jiye

A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial

一种由人工智能发现的用于治疗特发性肺纤维化的TNIK抑制剂:一项随机2a期试验

Xu, Zuojun; Ren, Feng; Wang, Ping; Cao, Jie; Tan, Chunting; Ma, Dedong; Zhao, Li; Dai, Jinghong; Ding, Yipeng; Fang, Haohui; Li, Huiping; Liu, Hong; Luo, Fengming; Meng, Ying; Pan, Pinhua; Xiang, Pingchao; Xiao, Zuke; Rao, Sujata; Satler, Carol; Liu, Sang; Lv, Yuan; Zhao, Heng; Chen, Shan; Cui, Hui; Korzinkin, Mikhail; Gennert, David; Zhavoronkov, Alex

Discovery of a bifunctional PKMYT1-targeting PROTAC empowered by AI-generation.

利用人工智能生成技术发现双功能PKMYT1靶向PROTAC。

Wang Yazhou, Wang Xiaomin, Liu Tingting, Wang Chao, Meng Qingshuo, Meng Fanye, Yu Jiaojiao, Liu Jinxin, Fan Yaya, Gennert David, Pun Frank W, Aliper Alex, Ren Feng, Zhang Man, Cai Xin, Ding Xiao, Zhavoronkov Alex

Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors.

利用人工智能生成技术设计的口服 ENPP1 抑制剂,作为下一代 STING 调节剂用于治疗实体瘤

Pu Congying, Cui Hui, Yu Huaxing, Cheng Xin, Zhang Man, Qin Luoheng, Ning Zhilin, Zhang Wen, Chen Shan, Qian Yuhang, Wang Feng, Wang Ling, Lin Xiaoxia, Gennert David, Pun Frank W, Ren Feng, Zhavoronkov Alex

Dynamic chromatin regulatory landscape of human CAR T cell exhaustion

人类 CAR-T 细胞衰竭的动态染色质调控格局

David G Gennert, Rachel C Lynn, Jeff M Granja, Evan W Weber, Maxwell R Mumbach, Yang Zhao, Zhana Duren, Elena Sotillo, William J Greenleaf, Wing H Wong, Ansuman T Satpathy, Crystal L Mackall, Howard Y Chang

c-Jun overexpression in CAR T cells induces exhaustion resistance

CAR T 细胞中 c-Jun 过表达可诱导 T 细胞耗竭抵抗。

Rachel C Lynn ,Evan W Weber # ,Elena Sotillo # ,David Gennert ,Peng Xu ,Zinaida Good ,Hima Anbunathan ,John Lattin ,Robert Jones ,Victor Tieu ,Surya Nagaraja ,Jeffrey Granja ,Charles F A de Bourcy ,Robbie Majzner ,Ansuman T Satpathy ,Stephen R Quake ,Michelle Monje ,Howard Y Chang ,Crystal L Mackall

HiChIRP reveals RNA-associated chromosome conformation

HiChIRP揭示RNA相关的染色体构象

Maxwell R Mumbach # ,Jeffrey M Granja # ,Ryan A Flynn ,Caitlin M Roake ,Ansuman T Satpathy ,Adam J Rubin ,Yanyan Qi ,Zhaozhao Jiang ,Shadi Shams ,Bryan H Louie ,Jimmy K Guo ,David G Gennert ,M Ryan Corces ,Paul A Khavari ,Maninjay K Atianand ,Steven E Artandi ,Katherine A Fitzgerald ,William J Greenleaf # ,Howard Y Chang #

Transcript-indexed ATAC-seq for precision immune profiling

基于转录本索引的ATAC-seq用于精准免疫分析

Ansuman T Satpathy # ,Naresha Saligrama # ,Jason D Buenrostro # ,Yuning Wei ,Beijing Wu ,Adam J Rubin ,Jeffrey M Granja ,Caleb A Lareau ,Rui Li ,Yanyan Qi ,Kevin R Parker ,Maxwell R Mumbach ,William S Serratelli ,David G Gennert ,Alicia N Schep ,M Ryan Corces ,Michael S Khodadoust ,Youn H Kim ,Paul A Khavari ,William J Greenleaf ,Mark M Davis ,Howard Y Chang

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells

肿瘤浸润T细胞中与激活无关的功能障碍的独特基因模块

Meromit Singer ,Chao Wang ,Le Cong ,Nemanja D Marjanovic ,Monika S Kowalczyk ,Huiyuan Zhang ,Jackson Nyman ,Kaori Sakuishi ,Sema Kurtulus ,David Gennert ,Junrong Xia ,John Y H Kwon ,James Nevin ,Rebecca H Herbst ,Itai Yanai ,Orit Rozenblatt-Rosen ,Vijay K Kuchroo ,Aviv Regev ,Ana C Anderson

CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq

CEL-Seq2:灵敏、高复用的单细胞 RNA 测序

Tamar Hashimshony, Naftalie Senderovich, Gal Avital, Agnes Klochendler, Yaron de Leeuw, Leon Anavy, Dave Gennert, Shuqiang Li, Kenneth J Livak, Orit Rozenblatt-Rosen, Yuval Dor, Aviv Regev, Itai Yanai