日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice

突变朊病毒蛋白增强NMDA受体活性,激活蛋白激酶C (PKC),并在小鼠中引发快速兴奋性毒性。

Lin, Joie; Callender, Julia A; Mayfield, Joshua E; McClatchy, Daniel B; Ojeda-Juárez, Daniel; Pourhamzeh, Mahsa; Soldau, Katrin; Kurt, Timothy D; Danque, Garrett A; Khuu, Helen; Ronson, Josephina E; Pizzo, Donald P; Du, Yixing; Gruber, Maxwell A; Sevillano, Alejandro M; Wang, Jin; Orrú, Christina D; Chen, Joy; Funk, Gail; Aguilar-Calvo, Patricia; Aulston, Brent D; Roy, Subhojit; Rho, Jong M; Bui, Jack D; Newton, Alexandra C; Lipton, Stuart A; Caughey, Byron; Patrick, Gentry N; Doré, Kim; Yates, John R 3rd; Sigurdson, Christina J

Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders.

对突触进行综合多组学表征,揭示了与神经发育障碍相关的 RNA 加工因子和泛素连接酶

Mei Yuan, Gosztyla Maya L, Tan Xinzhu, Dozier Lara E, Wilkinson Brent, McKetney Justin, Lee John, Chen Michael, Tsai Dorothy, Kopalle Hema, Gritsenko Marina A, Hartel Nicolas, Graham Nicholas A, Flores Ilse, Gilmore-Hall Stephen K, Xu Shuhao, Marquez Charlotte A, Liu Sophie N, Fong Dylan, Chen Jing, Licon Kate, Hong Derek, Wright Sarah N, Kreisberg Jason F, Nott Alexi, Smith Richard D, Qian Wei-Jun, Swaney Danielle L, Iakoucheva Lilia M, Krogan Nevan J, Patrick Gentry N, Zhou Yang, Feng Guoping, Coba Marcelo P, Yeo Gene W, Ideker Trey

Nootropic benzothiazoles promote dendritic spine formation by targeting fascin-1

促智苯并噻唑类药物通过靶向fascin-1促进树突棘形成。

Shivkumar, Aashish; Berg, Kyle R; Sibucao, Kevin C; Leriche, Geoffray; Dozier, Lara E; Espinoza, Carla A; Patrick, Gentry N; Gaieb, Zied; Seitz, Christian; Amaro, Rommie E; Park, Hyun-Hee; Hoe, Hyang-Sook; Wozniak, Jacob; Gonzalez, David J; Sinha, Saptarshi; Ghosh, Pradipta; Yang, Jerry

Inherently Emissive Puromycin Analogues for Live Cell Labelling

用于活细胞标记的固有发光嘌呤霉素类似物

Hadidi, Kaivin; Steinbuch, Kfir B; Dozier, Lara E; Patrick, Gentry N; Tor, Yitzhak

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model

阿尔茨海默病相关蛋白激酶 Cα 变体活性增强导致小鼠模型中的认知能力下降

Gema Lordén, Jacob M Wozniak, Kim Doré, Lara E Dozier, Chelsea Cates-Gatto, Gentry N Patrick, David J Gonzalez, Amanda J Roberts, Rudolph E Tanzi, Alexandra C Newton

Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus

朊病毒会诱发早期 Arc 反应,随后导致海马中的 mGluR5 减少

Daniel Ojeda-Juárez, Jessica A Lawrence, Katrin Soldau, Donald P Pizzo, Emily Wheeler, Patricia Aguilar-Calvo, Helen Khuu, Joy Chen, Adela Malik, Gail Funk, Percival Nam, Henry Sanchez, Michael D Geschwind, Chengbiao Wu, Gene W Yeo, Xu Chen, Gentry N Patrick, Christina J Sigurdson

Altered Phosphorylation of the Proteasome Subunit Rpt6 Has Minimal Impact on Synaptic Plasticity and Learning

蛋白酶体亚基 Rpt6 的磷酸化改变对突触可塑性和学习的影响很小

Samantha L Scudder, Frankie R Gonzales, Kristin K Howell, Ivar S Stein, Lara E Dozier, Stephan G Anagnostaras, Karen Zito, Gentry N Patrick

Biosynthesis of Orthogonal Molecules Using Ferredoxin and Ferredoxin-NADP+ Reductase Systems Enables Genetically Encoded PhyB Optogenetics

利用铁氧还蛋白和铁氧还蛋白-NADP+还原酶系统进行正交分子生物合成,实现基因编码的 PhyB 光遗传学

Phillip Kyriakakis, Marianne Catanho, Nicole Hoffner, Walter Thavarajah, Vincent J Hu, Syh-Shiuan Chao, Athena Hsu, Vivian Pham, Ladan Naghavian, Lara E Dozier, Gentry N Patrick, Todd P Coleman

Proteasome phosphorylation regulates cocaine-induced sensitization

蛋白酶体磷酸化调节可卡因诱导的致敏作用

Frankie R Gonzales, Kristin K Howell, Lara E Dozier, Stephan G Anagnostaras, Gentry N Patrick

Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain

胍基化新霉素偶联物可增强鼻内酶替代疗法在大脑中的疗效

Tong, Wenyong; Dwyer, Chrissa A; Thacker, Bryan E; Glass, Charles A; Brown, Jillian R; Hamill, Kristina; Moremen, Kelley W; Sarrazin, Stéphane; Gordts, Philip L S M; Dozier, Lara E; Patrick, Gentry N; Tor, Yitzhak; Esko, Jeffrey D