Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration.
慢性氧化应激促进 GADD34 介导的 TAR DNA 结合蛋白 TDP-43 的磷酸化,这种修饰与神经退行性变有关
期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M117.814111
Goh Catherine Wenhui, Lee Irene Chengjie, Sundaram Jeyapriya Rajameenakshi, George Simi Elizabeth, Yusoff Permeen, Brush Matthew Hayden, Sze Newman Siu Kwan, Shenolikar Shirish