Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells
mTOR 复合物 1 下调 PERK 活性和 eIF2α 丝氨酸 51 磷酸化,在结节性硬化症缺陷细胞中引发促氧化和促死亡作用
期刊:Cell Death & Disease
影响因子:8.1
doi:10.1038/s41419-018-0326-2
Jothilatha Krishnamoorthy, Clara Tenkerian, Jyotsana Gupta, Nour Ghaddar, Shuo Wang, Cedric Darini, Kirk A Staschke, Abhishek Ghosh, Valentina Gandin, Ivan Topisirovic, Arnold S Kristof, Maria Hatzoglou, George Simos, Antonis E Koromilas
信号转导
免疫
神经
表观遗传
多发性硬化症
其它细胞
MAPK/ERK
mTOR