日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single-cell genomics highlight MYC-associated metabolic activation and altered cell interactions in T-prolymphocytic leukemia progression

单细胞基因组学揭示了MYC相关的代谢激活和T前淋巴细胞白血病进展中的细胞相互作用改变

Wahnschaffe, Linus; Jungherz, Dennis; Müller, Tony A; Pemovska, Tea; Pichler, Alexander; Poulain, Stéphanie; Julia, Edith; Timonen, Sanna; Böttcher, Martin; Jiang, Qu; Beverungen, David; Bischoff, Julia; Franitza, Marek; Georgomanolis, Theodoros; Becker, Kerstin; Hallek, Michael; Mougiakakos, Dimitrios; Zenz, Thorsten; Mustjoki, Satu; Bachy, Emmanuel; Herbaux, Charles; Schrader, Alexandra; Pflug, Natali; Staber, Philipp B; Braun, Till; Herling, Marco

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

线粒体代谢维持DNMT3A-R882突变克隆性造血

Malgorzata Gozdecka ,Monika Dudek # ,Sean Wen # ,Muxin Gu ,Richard J Stopforth ,Justyna Rak ,Aristi Damaskou ,Guinevere L Grice ,Matthew A McLoughlin ,Laura Bond ,Rachael Wilson ,George Giotopoulos ,Vijaya Mahalingam Shanmugiah ,Rula Bany Bakar ,Eliza Yankova ,Jonathan L Cooper ,Nisha Narayan ,Sarah J Horton ,Ryan Asby ,Dean C Pask ,Annalisa Mupo ,Graham Duddy ,Ludovica Marando ,Theodoros Georgomanolis ,Paul Carter ,Amirtha Priya Ramesh ,William G Dunn ,Clea Barcena ,Paolo Gallipoli ,Kosuke Yusa ,Slavé Petrovski ,Penny Wright ,Pedro M Quiros ,Christian Frezza ,James A Nathan ,Arthur Kaser ,Siddhartha Kar ,Konstantinos Tzelepis ,Jonathan Mitchell ,Margarete A Fabre ,Brian J P Huntly ,George S Vassiliou

2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction.

2-羟基戊二酸介导棕色脂肪细胞变白,并伴随线粒体功能障碍引起的细胞核软化

Kaul Harshita, Isermann Lea, Senft Katharina, Popovic Milica, Georgomanolis Theodoros, Baumann Linda, Sivanesan Pujyanathan, Pouikli Andromachi, Nolte Hendrik, Lucic Bojana, Hildebrandt Ximena, Seidel Katrin, Gnad Thorsten, Gaedke Felix, Göbel Ulrike, Peters Franziska, Cherevatenko Maksym, Park Joo Hyun, Schauss Astrid, Peltzer Nieves, Brüning Jens Claus, Kornfeld Jan-Wilhelm, Pfeifer Alexander, Langer Thomas, Lusic Marina, Wickström Sara A, Frezza Christian, Trifunovic Aleksandra

Autophagy regulator ATG5 preserves cerebellar function by safeguarding its glycolytic activity

自噬调节剂 ATG5 通过保护小脑的糖酵解活性来维持小脑功能

Janine Tutas, Marianna Tolve, Ebru Özer-Yildiz, Lotte Ickert, Ines Klein, Quinn Silverman, Filip Liebsch, Frederik Dethloff, Patrick Giavalisco, Heike Endepols, Theodoros Georgomanolis, Bernd Neumaier, Alexander Drzezga, Guenter Schwarz, Bernard Thorens, Graziana Gatto, Christian Frezza, Natalia L K

Remodeling of the endothelial cell transcriptional program via paracrine and DNA-binding activities of MPO

通过 MPO 的旁分泌和 DNA 结合活性重塑内皮细胞转录程序

Ruiyuan Zheng, Kyle Moynahan, Theodoros Georgomanolis, Egor Pavlenko, Simon Geissen, Athanasia Mizi, Simon Grimm, Harshal Nemade, Rizwan Rehimi, Jil Bastigkeit, Jan-Wilm Lackmann, Matti Adam, Alvaro Rada-Iglesias, Peter Nuernberg, Anna Klinke, Simon Poepsel, Stephan Baldus, Argyris Papantonis, Yulia

Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life

孕产妇和围产期肥胖通过 IL-6-FoxO1 轴在以后的生活中诱发支气管阻塞和肺动脉高压

Jaco Selle #, Katharina Dinger #, Vanessa Jentgen #, Daniela Zanetti, Johannes Will, Theodoros Georgomanolis, Christina Vohlen, Rebecca Wilke, Baktybek Kojonazarov, Oleksiy Klymenko, Jasmine Mohr, Silke V Koningsbruggen-Rietschel, Christopher J Rhodes, Anna Ulrich, Dharmesh Hirani, Tim Nestler, Marg

NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition

肝细胞中的 NIK/MAP3K14 通过抑制 JAK2/STAT5 调控 NASH 向肝细胞癌的进展

Anna Juliane Vesting, Alexander Jais, Paul Klemm, Lukas Steuernagel, Peter Wienand, Morten Fog-Tonnesen, Henning Hvid, Anna-Lena Schumacher, Christian Kukat, Hendrik Nolte, Theodoros Georgomanolis, Janine Altmüller, Manolis Pasparakis, Andreas Schmidt, Marcus Krüger, Marc Schmidt Supprian, Ari Waism

Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19

长寿巨噬细胞重编程驱动新冠病毒中刺突蛋白介导的炎症小体活化

Sebastian J Theobald, Alexander Simonis, Theodoros Georgomanolis, Christoph Kreer, Matthias Zehner, Hannah S Eisfeld, Marie-Christine Albert, Jason Chhen, Susanne Motameny, Florian Erger, Julia Fischer, Jakob J Malin, Jessica Gräb, Sandra Winter, Andromachi Pouikli, Friederike David, Boris Böll, Phi

HMGB1 coordinates SASP-related chromatin folding and RNA homeostasis on the path to senescence

HMGB1 在衰老过程中协调 SASP 相关的染色质折叠和 RNA 稳态

Konstantinos Sofiadis #, Natasa Josipovic #, Milos Nikolic #, Yulia Kargapolova, Nadine Übelmesser, Vassiliki Varamogianni-Mamatsi, Anne Zirkel, Ioanna Papadionysiou, Gary Loughran, James Keane, Audrey Michel, Eduardo G Gusmao, Christian Becker, Janine Altmüller, Theodore Georgomanolis, Athanasia Mi

DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift

长期体外细胞培养过程中的 DNA 甲基化变化是由表观遗传漂变引起的

Julia Franzen, Theodoros Georgomanolis, Anton Selich, Chao-Chung Kuo, Reinhard Stöger, Lilija Brant, Melita Sara Mulabdić, Eduardo Fernandez-Rebollo, Clara Grezella, Alina Ostrowska, Matthias Begemann, Miloš Nikolić, Björn Rath, Anthony D Ho, Michael Rothe, Axel Schambach, Argyris Papantonis, Wolfga