日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Novel Skp1 inhibitor has potent preclinical efficacy against castration-resistant prostate cancer

新型Skp1抑制剂对去势抵抗性前列腺癌具有显著的临床前疗效

Li, Xin; Mamouni, Kenza; Zhao, Rui; Bai, Lijuan; Chen, Yanhua; Wu, Yifei; Xie, Zhong-Ru; Sautto, Giuseppe A; Liu, Degang; Bowen, Nathan J; Danaher, Alira; Li, Dehong; Cook, Nicholas; Grayson, Skylar; Zhu, Jedidiah; Coleman, Ilsa M; Nelson, Peter S; Bao, Qichao; Zhou, Jia; Osunkoya, Adeboye O; Kucuk, Omer; Gera, Lajos; Wu, Daqing

Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-mediated ARDS.

琥珀酸激活 SUCNR1 使重伤患者易患中性粒细胞介导的 ARDS

Nunns Geoffrey R, Vigneshwar Navin, Kelher Marguerite R, Stettler Gregory R, Gera Lajos, Reisz Julie A, D'Alessandro Angelo, Ryon Joshua, Hansen Kirk C, Gamboni Fabia, Moore Ernest E, Peltz Erik D, Cohen Mitchell J, Jones Kenneth L, Sauaia Angela, Liang Xiayuan, Banerjee Anirban, Ghasabyan Arsen, Chandler James G, Rodawig Sophia, Jones Carter, Eitel Andrew, Hom Patrick, Silliman Christopher C

Pharmacological inhibition of noncanonical EED-EZH2 signaling overcomes chemoresistance in prostate cancer.

通过药物抑制非经典 EED-EZH2 信号通路可以克服前列腺癌的化疗耐药性

Li Xin, Gera Lajos, Zhang Shumin, Chen Yanhua, Lou Lei, Wilson Lauren Marie, Xie Zhong-Ru, Sautto Giuseppe, Liu Degang, Danaher Alira, Mamouni Kenza, Yang Yang, Du Yuhong, Fu Haian, Kucuk Omer, Osunkoya Adeboye O, Zhou Jia, Wu Daqing

Small molecule BKM1972 inhibits human prostate cancer growth and overcomes docetaxel resistance in intraosseous models

小分子BKM1972可抑制人前列腺癌生长,并在骨内模型中克服多西他赛耐药性

Chen, Yanhua; Gera, Lajos; Zhang, Shumin; Li, Xin; Yang, Yang; Mamouni, Kenza; Wu, Alyssa Y; Liu, HongYan; Kucuk, Omer; Wu, Daqing

Platform technology to generate broadly cross-reactive antibodies to α-helical epitopes in hemagglutinin proteins from influenza A viruses

用于生成针对甲型流感病毒血凝素蛋白中α螺旋表位的广谱交叉反应抗体的平台技术

Jiang, Ziqing; Gera, Lajos; Mant, Colin T; Hirsch, Brooke; Yan, Zhe; Shortt, Jonathan A; Pollock, David D; Qian, Zhaohui; Holmes, Kathryn V; Hodges, Robert S

Inhibition of skeletal growth of human prostate cancer by the combination of docetaxel and BKM1644: an aminobisphosphonate derivative

多西他赛与氨基双膦酸盐衍生物BKM1644联合用药抑制人前列腺癌骨骼生长

Zhang, Shumin; Gera, Lajos; Mamouni, Kenza; Li, Xin; Chen, Zhengjia; Kucuk, Omer; Wu, Daqing

Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension

调节性T细胞可限制血管内皮损伤并预防肺动脉高压。

Tamosiuniene, Rasa; Tian, Wen; Dhillon, Gundeep; Wang, Lijuan; Sung, Yon K; Gera, Lajos; Patterson, Andrew J; Agrawal, Rani; Rabinovitch, Marlene; Ambler, Kelly; Long, Carlin S; Voelkel, Norbert F; Nicolls, Mark R

Rational design of α-helical antimicrobial peptides to target Gram-negative pathogens, Acinetobacter baumannii and Pseudomonas aeruginosa: utilization of charge, 'specificity determinants,' total hydrophobicity, hydrophobe type and location as design parameters to improve the therapeutic ratio

合理设计靶向革兰氏阴性病原体鲍曼不动杆菌和铜绿假单胞菌的α螺旋抗菌肽:利用电荷、“特异性决定因素”、总疏水性、疏水基团类型和位置作为设计参数以提高治疗比率

Jiang, Ziqing; Vasil, Adriana I; Gera, Lajos; Vasil, Michael L; Hodges, Robert S

Bradykinin antagonist dimer, CU201, inhibits the growth of human lung cancer cell lines by a "biased agonist" mechanism

缓激肽拮抗剂二聚体CU201通过“偏向性激动剂”机制抑制人肺癌细胞系的生长。

Chan, Daniel; Gera, Lajos; Stewart, John; Helfrich, Barbara; Verella-Garcia, Marileila; Johnson, Gary; Baron, Anna; Yang, Jie; Puck, Theodore; Bunn, Paul Jr