日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The inhibition of YAP Signaling Prevents Chronic Biliary Fibrosis in the Abcb4-/- Model by Modulation of Hepatic Stellate Cell and Bile Duct Epithelium Cell Pathophysiology

YAP 信号抑制可通过调节肝星状细胞和胆管上皮细胞病理生理学来预防 Abcb4-/- 模型中的慢性胆道纤维化

Liangtao Ye, Andreas Ziesch, Julia S Schneider, Andrea Ofner, Hanno Nieß, Gerald Denk, Simon Hohenester, Doris Mayr, Ujjwal M Mahajan, Stefan Munker, Najib Ben Khaled, Ralf Wimmer, Alexander L Gerbes, Julia Mayerle, Yulong He, Andreas Geier, Enrico N De Toni, Changhua Zhang, Florian P Reiter

The acidic microenvironment in the perisinusoidal space critically determines bile salt-induced activation of hepatic stellate cells

窦周空间的酸性微环境关键决定了胆汁盐诱导的肝星状细胞的活化

Jingguo Li, Shun Yao, Sebastian Zimny, Dennis Koob, Hai Jin, Ralf Wimmer, Gerald Denk, Biguang Tuo #, Simon Hohenester #

p70 Ribosomal Protein S6 Kinase Is a Checkpoint of Human Hepatic Stellate Cell Activation and Liver Fibrosis in Mice

p70 核糖体蛋白 S6 激酶是人类肝星状细胞活化和小鼠肝纤维化的检查点

Florian P Reiter, Liangtao Ye, Andrea Ofner, Tobias S Schiergens, Andreas Ziesch, Lydia Brandl, Najib Ben Khaled, Simon Hohenester, Ralf Wimmer, Renate Artmann, Yulong He, Serene M L Lee, Doris Mayr, Changhua Zhang, Alexander L Gerbes, Julia Mayerle, Gerald Denk, Enrico N De Toni

Hydrophobic Bile Salts Induce Pro-Fibrogenic Proliferation of Hepatic Stellate Cells through PI3K p110 Alpha Signaling

疏水性胆汁盐通过 PI3K p110 Alpha 信号诱导肝星状细胞促纤维化增殖

Sebastian Zimny, Dennis Koob, Jingguo Li, Ralf Wimmer, Tobias Schiergens, Jutta Nagel, Florian Paul Reiter, Gerald Denk, Simon Hohenester

Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis

甘氨鹅去氧胆酸促进肝细胞性胆汁淤积小鼠肝纤维化

Simon Hohenester, Veronika Kanitz, Andreas E Kremer, Coen C Paulusma, Ralf Wimmer, Helen Kuehn, Gerald Denk, David Horst, Ronald Oude Elferink, Ulrich Beuers

A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease Rats

高热量饮食会加重威尔逊病大鼠的线粒体功能障碍并引发严重的肝损伤

Claudia Einer, Christin Leitzinger, Josef Lichtmannegger, Carola Eberhagen, Tamara Rieder, Sabine Borchard, Ralf Wimmer, Gerald Denk, Bastian Popper, Frauke Neff, Elena V Polishchuk, Roman S Polishchuk, Stefanie M Hauck, Christine von Toerne, Jennifer-Christin Müller, Uwe Karst, Bipin S Baral, Alan

Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut

Nlrp3 依赖性 IL-1β 抑制肠道中的 CD103+ 树突状细胞分化

Rachel Mak'Anyengo, Peter Duewell, Cornelia Reichl, Christine Hörth, Hans-Anton Lehr, Sandra Fischer, Thomas Clavel, Gerald Denk, Simon Hohenester, Sebastian Kobold, Stefan Endres, Max Schnurr, Christian Bauer

Methanobactin reverses acute liver failure in a rat model of Wilson disease

甲烷杆菌素可逆转威尔逊病大鼠模型中的急性肝衰竭

Josef Lichtmannegger, Christin Leitzinger, Ralf Wimmer, Sabine Schmitt, Sabine Schulz, Yaschar Kabiri, Carola Eberhagen, Tamara Rieder, Dirk Janik, Frauke Neff, Beate K Straub, Peter Schirmacher, Alan A DiSpirito, Nathan Bandow, Bipin S Baral, Andrew Flatley, Elisabeth Kremmer, Gerald Denk, Florian

Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction

乙肝和丙肝中功能失调的 CD8+ T 细胞的特点是缺乏抗原特异性 T-bet 诱导

Peter D Kurktschiev, Bijan Raziorrouh, Winfried Schraut, Markus Backmund, Martin Wächtler, Clemens-Martin Wendtner, Bertram Bengsch, Robert Thimme, Gerald Denk, Reinhart Zachoval, Andrea Dick, Michael Spannagl, Jürgen Haas, Helmut M Diepolder, Maria-Christina Jung, Norbert H Gruener

Inhibitory phenotype of HBV-specific CD4+ T-cells is characterized by high PD-1 expression but absent coregulation of multiple inhibitory molecules

HBV 特异性 CD4+ T 细胞的抑制表型以 PD-1 表达高但缺乏多种抑制分子的共调节为特征

Bijan Raziorrouh, Malte Heeg, Peter Kurktschiev, Winfried Schraut, Reinhart Zachoval, Clemens Wendtner, Martin Wächtler, Michael Spannagl, Gerald Denk, Axel Ulsenheimer, Bertram Bengsch, Hanspeter Pircher, Helmut M Diepolder, Norbert H Grüner, Maria-Christina Jung