日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Biosafety and efficacy of Kv7 activating rdHSV-CA8∗ analgesic gene therapy for chronic pain via the intra-articular route in mice

Kv7激活rdHSV-CA8*镇痛基因疗法经关节内途径治疗小鼠慢性疼痛的生物安全性和有效性

Levitt, Roy C; Kandel, Munal B; Zhuang, Gerald Z; Goins, William F; Sarantopoulos, Konstantinos D; Glorioso, Joseph C

Phospho-CREB Regulation on NMDA Glutamate Receptor 2B and Mitochondrial Calcium Uniporter in the Ventrolateral Periaqueductal Gray Controls Chronic Morphine Withdrawal in Male Rats.

磷酸化 CREB 对 NMDA 谷氨酸受体 2B 和线粒体钙单向转运蛋白在腹外侧导水管周围灰质中的调节控制雄性大鼠的慢性吗啡戒断

Yi Hyun, Gu Jun, Hamilton Peter J, Liu Shue, Zhu Shoumin, Ikegami Daigo, Hayashi Kentaro, Kashiwagi Yuta, Iida Takafumi, Liu Qiaofeng, Zhu Xun, Tong Xiaoying, Peng Dunfa, Zhuang Gerald Z, Pardo Marta, El-Rifai Wael, Levitt Roy C, Nestler Eric J, Hao Shuanglin

rdHSV-CA8 non-opioid analgesic gene therapy decreases somatosensory neuronal excitability by activating Kv7 voltage-gated potassium channels

rdHSV-CA8非阿片类镇痛基因疗法通过激活Kv7电压门控钾通道降低体感神经元的兴奋性。

Kandel, Munal B; Zhuang, Gerald Z; Goins, William F; Marzulli, Marco; Zhang, Mingdi; Glorioso, Joseph C; Kang, Yuan; Levitt, Alexandra E; Kwok, Wai-Meng; Levitt, Roy C; Sarantopoulos, Konstantinos D

Disease-modifying rdHSV-CA8* non-opioid analgesic gene therapy treats chronic osteoarthritis pain by activating Kv7 voltage-gated potassium channels

疾病修饰 rdHSV-CA8* 非阿片类镇痛基因疗法通过激活 Kv7 电压门控钾通道治疗慢性骨关节炎疼痛

Gerald Z Zhuang, William F Goins, Munal B Kandel, Marco Marzulli, Mingdi Zhang, Joseph C Glorioso, Yuan Kang, Alexandra E Levitt, Konstantinos D Sarantopoulos, Roy C Levitt

Aquatic habitats of the malaria vector Anopheles funestus in rural south-eastern Tanzania

坦桑尼亚东南部农村地区疟疾媒介蚊子(Anopheles funestus)的水生栖息地

Nambunga, Ismail H; Ngowo, Halfan S; Mapua, Salum A; Hape, Emmanuel E; Msugupakulya, Betwel J; Msaky, Dickson S; Mhumbira, Nicolaus T; Mchwembo, Karim R; Tamayamali, Gerald Z; Mlembe, Slyakus V; Njalambaha, Rukiyah M; Lwetoijera, Dickson W; Finda, Marceline F; Govella, Nicodem J; Matoke-Muhia, Damaris; Kaindoa, Emmanuel W; Okumu, Fredros O

Profound analgesia is associated with a truncated peptide resulting from tissue specific alternative splicing of DRG CA8-204 regulated by an exon-level cis-eQTL

深度镇痛与由外显子水平顺式 eQTL 调控的 DRG CA8-204 组织特异性剪接产生的截短肽有关

Udita Upadhyay, Gerald Z Zhuang, Luda Diatchenko, Marc Parisien, Yuan Kang, Konstantinos D Sarantopoulos, Eden R Martin, Shad B Smith, William Maixner, Roy C Levitt

Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice

人碳酸酐酶-8 AAV8基因疗法抑制神经生长因子信号传导,从而在小鼠中产生持久镇痛和抗痛觉过敏作用

Zhuang, Gerald Z; Upadhyay, Udita; Tong, Xiaoying; Kang, Yuan; Erasso, Diana M; Fu, Eugene S; Sarantopoulos, Konstantinos D; Martin, Eden R; Wiltshire, Tim; Diatchenko, Luda; Smith, Shad B; Maixner, William; Levitt, Roy C

Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway

碳酸酐酶-8 通过抑制 ITPR1-胞浆游离钙通路调节炎症疼痛

Gerald Z Zhuang, Benjamin Keeler, Jeff Grant, Laura Bianchi, Eugene S Fu, Yan Ping Zhang, Diana M Erasso, Jian-Guo Cui, Tim Wiltshire, Qiongzhen Li, Shuanglin Hao, Konstantinos D Sarantopoulos, Keith Candiotti, Sarah M Wishnek, Shad B Smith, William Maixner, Luda Diatchenko, Eden R Martin, Roy C Lev

Carbonic anhydrase-8 gene therapy inhibits the ITPR1-cytosolic free calcium pathway producing analgesia and anti-hyperalgesia

碳酸酐酶-8基因疗法抑制ITPR1-胞质游离钙通路,产生镇痛和抗痛觉过敏作用。

Hall, Neil; Levitt, Roy C; Zhuang, Gerald Z; Keeler, Benjamin; Grant, Jeff; Bianchi, Laura; Fu, Eugene S; Zhang, Yan Ping; Erasso, Diana M; Cui, Jian Guo; Wiltshire, Tim; Li, Qiongzhen; Hao, Shuanglin; Sarantopoulos, Konstantinos D; Candiotti, Keith; Smith, Shad B; Maixner, William; Diatchenko, Luda; Martin, Eden R

Small-fiber polyneuropathy (SFPN), a common underlying diagnosis in syndromes involving unexplained chronic pain and multi-system symptoms

小纤维多发性神经病(SFPN)是涉及不明原因慢性疼痛和多系统症状的综合征中常见的潜在诊断。

Diatchenko, Luda; Scholz, Joachim; Tajerian, Maral; Alvarado, Sebastian; Millecamps, Magali; Szyf, Moshe; Stone, Laura S; Westlund, Karin N; McIlwrath, Sabrina L; Oz, Helieh S; Williams, David A; Kim, Yu Shin; Chu, Yuxia; Han, Liang; Park, Kyougsook; Li, Man; Li, Zhe; LaVinka, Pamela Colleen; Caterina, Michael J; Ren, Ke; Dubner, Ronald; Wei, Feng; Dong, Xinzhong; Barski, Artem; Cuddapah, Suresh; Kartashov, Andrey V; Imamichi, Hiromi; Yang, Wenjing; Peng, Weiqun; Lane, H Clifford; Zhao, Keji; Yoo, Seungyeul; Lee, Eunjee; Zhu, Jun; Gereau IV, Robert W; Cavallone, Laura F; Gersbach, Charles A; Goldman, David; ABD-Elsayed, Alaa; Kohan, Kevin; Zuo, Xiaozhuo; Cha, Meuonghoon; Ling, Jennifer; Gu, Jianguo; Levitt, Roy C; Zhuang, Gerald Z; Keeler, Benjamin; Grant, Jeff; Bianchi, Laura; Fu, Eugene S; Zhang, Yan Ping; Erasso, Diana M; Cui, Jian Guo; Wiltshire, Tim; Li, Qiongzhen; Hao, Shuanglin; Sarantopoulos, Konstantinos D; Candiotti, Keith; Smith, Shad B; Maixner, William; Diatchenko, Luda; Martin, Eden R; Chen, Yong; Wang, Fan; Liedtke, Wolfgang; Lötsch, Jörn; Ultsch, Alfred; Chen, Yong; Guilak, Farshid; Gereau IV, Robert W; Wang, Fan; Liedtke, Wolfgang; Harper, Daniel E; Pallazola, Vincent; Williams, David A; Harte, Steven; Clauw, Daniel J; Shtein, Roni M; King, Christopher; Ribeiro-Dasilva, Margarete; Fillingim, Roger; Wallet, Shannon; Godel, JH; Foley, BF; Nicot, R; Horton, MJ; Barton, ER; Ferri, J; Raoul, G; Vieira, AR; Sciote, JJ; Smith, Shad B; Bair, Eric; Xue, Wei; Slade, Gary D; Dubner, Ronald; Fillingim, Roger B; Greenspan, Joel D; Ohrbach, Richard; Knott, Charlie; Diatchenko, Luda; Maixner, William; Lang, Magdalena; Treister, Roi; Klein, Max; Oaklander, Anne Louise; Slade, Gary D; Ro, Jin Y; Chung, Man-Kyo; Lee, Jong S; Saloman, Jami L; Joseph, John; Schmidt, Brian L; Kim, Hyangin; McCabe, Michael F; Lim, Grewo; Chen, Lucy; Mao, Jianren; Nackley, Andrea G; Oaklander, Anne Louise; Downs, Heather; Herzog, Zeva Daniela; Klein, Max