日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GUK1 activation is a metabolic liability in lung cancer

GUK1激活是肺癌的一种代谢缺陷

Jaime L Schneider,Kiran Kurmi,Yutong Dai,Ishita Dhiman,Shakchhi Joshi,Brandon M Gassaway,Christian W Johnson,Nicole Jones,Zongyu Li,Christian P Joschko,Toshio Fujino,Joao A Paulo,Satoshi Yoda,Gerard Baquer,Daniela Ruiz,Sylwia A Stopka,Liam Kelley,Andrew Do,Mari Mino-Kenudson,Lecia V Sequist,Jessica J Lin,Nathalie Y R Agar,Steven P Gygi,Kevin M Haigis,Aaron N Hata,Marcia C Haigis

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

ONC201治疗H3K27M突变型弥漫性中线胶质瘤的临床疗效是由整合代谢和表观遗传通路紊乱驱动的

Sriram Venneti # ,Abed Rahman Kawakibi # ,Sunjong Ji # ,Sebastian M Waszak # ,Stefan R Sweha # ,Mateus Mota # ,Matthew Pun # ,Akash Deogharkar ,Chan Chung ,Rohinton S Tarapore ,Samuel Ramage ,Andrew Chi ,Patrick Y Wen ,Isabel Arrillaga-Romany ,Tracy T Batchelor ,Nicholas A Butowski ,Ashley Sumrall ,Nicole Shonka ,Rebecca A Harrison ,John de Groot ,Minesh Mehta ,Matthew D Hall ,Doured Daghistani ,Timothy F Cloughesy ,Benjamin M Ellingson ,Kevin Beccaria ,Pascale Varlet ,Michelle M Kim ,Yoshie Umemura ,Hugh Garton ,Andrea Franson ,Jonathan Schwartz ,Rajan Jain ,Maureen Kachman ,Heidi Baum ,Charles F Burant ,Sophie L Mottl ,Rodrigo T Cartaxo ,Vishal John ,Dana Messinger ,Tingting Qin ,Erik Peterson ,Peter Sajjakulnukit ,Karthik Ravi ,Alyssa Waugh ,Dustin Walling ,Yujie Ding ,Ziyun Xia ,Anna Schwendeman ,Debra Hawes ,Fusheng Yang ,Alexander R Judkins ,Daniel Wahl ,Costas A Lyssiotis ,Daniel de la Nava ,Marta M Alonso ,Augustine Eze ,Jasper Spitzer ,Susanne V Schmidt ,Ryan J Duchatel ,Matthew D Dun ,Jason E Cain ,Li Jiang ,Sylwia A Stopka ,Gerard Baquer ,Michael S Regan ,Mariella G Filbin ,Nathalie Y R Agar ,Lili Zhao ,Chandan Kumar-Sinha ,Rajen Mody ,Arul Chinnaiyan ,Ryo Kurokawa ,Drew Pratt ,Viveka N Yadav ,Jacques Grill ,Cassie Kline ,Sabine Mueller ,Adam Resnick ,Javad Nazarian ,Joshua E Allen ,Yazmin Odia ,Sharon L Gardner ,Carl Koschmann

Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function

癌代谢物 d-2HG 改变 T 细胞代谢,损害 CD8+ T 细胞功能

Giulia Notarangelo, Jessica B Spinelli, Elizabeth M Perez, Gregory J Baker, Kiran Kurmi, Ilaria Elia, Sylwia A Stopka, Gerard Baquer, Jia-Ren Lin, Alexandra J Golby, Shakchhi Joshi, Heide F Baron, Jefte M Drijvers, Peter Georgiev, Alison E Ringel, Elma Zaganjor, Samuel K McBrayer, Peter K Sorger, Ar

PARP-inhibition reprograms macrophages toward an anti-tumor phenotype

PARP抑制剂可将巨噬细胞重编程为抗肿瘤表型

Lin Wang ,Dan Wang ,Olmo Sonzogni ,Shizhong Ke ,Qi Wang ,Abhishek Thavamani ,Felipe Batalini ,Sylwia A Stopka ,Michael S Regan ,Steven Vandal ,Shengya Tian ,Jocelin Pinto ,Andrew M Cyr ,Vanessa C Bret-Mounet ,Gerard Baquer ,Hans P Eikesdal ,Min Yuan ,John M Asara ,Yujing J Heng ,Peter Bai ,Nathalie Y R Agar ,Gerburg M Wulf