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Activation of pancreatic stellate cells attenuates intracellular Ca2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites

胰腺星状细胞的激活会因 TRPA1 下调而减弱细胞内 Ca2+ 信号，并防止酒精代谢物引起的细胞死亡

Agnieszka A Kusiak, Monika A Jakubowska, Kinga B Stopa, Xiaoying Zhang, Wei Huang, Julia V Gerasimenko, Oleg V Gerasimenko, Robert Sutton, Ole H Petersen, Pawel E Ferdek

代谢

SARS-CoV-2 S Protein Subunit 1 Elicits Ca(2+) Influx - Dependent Ca(2+) Signals in Pancreatic Stellate Cells and Macrophages In Situ.

SARS-CoV-2 S 蛋白亚基 1 在原位胰腺星状细胞和巨噬细胞中引发 Ca(2+) 内流依赖性 Ca(2+) 信号

期刊:Function

影响因子:3.8

doi:10.1093/function/zqac002

Gerasimenko Julia V, Petersen Ole H, Gerasimenko Oleg V

Calcium Signaling in Pancreatic Immune Cells In situ.

胰腺免疫细胞原位钙信号传导

期刊:Function

影响因子:3.8

doi:10.1093/function/zqaa026

Gryshchenko Oleksiy, Gerasimenko Julia V, Petersen Ole H, Gerasimenko Oleg V

细胞生物学

发表日期：2021

文献求助收藏

ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca(2+) -signalling dysregulation or toxicity in pancreatic acinar cells

ABT-199（维奈托克）是一种BH3模拟物Bcl-2抑制剂，不会引起胰腺腺泡细胞的Ca(2+)信号传导紊乱或毒性。

期刊:British Journal of Pharmacology

影响因子:7.7

doi:10.1111/bph.14505

Jakubowska, Monika A; Kerkhofs, Martijn; Martines, Claudio; Efremov, Dimitar G; Gerasimenko, Julia V; Gerasimenko, Oleg V; Petersen, Ole H; Bultynck, Geert; Vervliet, Tim; Ferdek, Pawel E

Calcium signalling in the acinar environment of the exocrine pancreas: physiology and pathophysiology

外分泌胰腺腺泡环境中的钙信号传导：生理学和病理生理学

期刊:Journal of Physiology-London

影响因子:4.4

doi:10.1113/JP275395

Gryshchenko, Oleksiy; Gerasimenko, Julia V; Peng, Shuang; Gerasimenko, Oleg V; Petersen, Ole H

信号转导

发表日期：2018

文献求助收藏

BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides

BH3 模拟物在胰腺腺泡细胞中诱发的 Ca2+ 信号依赖于 Bax，并且可被 Ca2+ 样肽降低

期刊:Cell Death & Disease

影响因子:8.1

doi:10.1038/cddis.2017.41

Pawel E Ferdek, Monika A Jakubowska, Polina Nicolaou, Julia V Gerasimenko, Oleg V Gerasimenko, Ole H Petersen

Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium-driven bile uptake

胆汁酸诱导胰腺星状细胞坏死，这一过程依赖于钙离子内流和钠离子驱动的胆汁吸收。

期刊:Journal of Physiology-London

影响因子:4.4

doi:10.1113/JP272774

Ferdek, Pawel E; Jakubowska, Monika A; Gerasimenko, Julia V; Gerasimenko, Oleg V; Petersen, Ole H

Ca(2+) signals mediated by bradykinin type 2 receptors in normal pancreatic stellate cells can be inhibited by specific Ca(2+) channel blockade

正常胰腺星状细胞中缓激肽 2 型受体介导的 Ca(2+) 信号可被特异性 Ca(2+) 通道阻滞剂抑制

期刊:Journal of Physiology-London

影响因子:2.1

doi:10.1113/JP271468

Oleksiy Gryshchenko, Julia V Gerasimenko, Oleg V Gerasimenko, Ole H Petersen

Ca(2+) Signaling and ATP Production in Pancreatic Cancer

胰腺癌中的Ca(2+)信号传导和ATP生成

The role of Ca(2+) signalling in the pathology of exocrine pancreas

Ca(2+)信号在胰腺外分泌病理学中的作用

Activation of pancreatic stellate cells attenuates intracellular Ca2+ signals due to downregulation of TRPA1 and protects against cell death induced by alcohol metabolites

胰腺星状细胞的激活会因 TRPA1 下调而减弱细胞内 Ca2+ 信号，并防止酒精代谢物引起的细胞死亡

SARS-CoV-2 S Protein Subunit 1 Elicits Ca(2+) Influx - Dependent Ca(2+) Signals in Pancreatic Stellate Cells and Macrophages In Situ.

SARS-CoV-2 S 蛋白亚基 1 在原位胰腺星状细胞和巨噬细胞中引发 Ca(2+) 内流依赖性 Ca(2+) 信号

Calcium Signaling in Pancreatic Immune Cells In situ.

胰腺免疫细胞原位钙信号传导

ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca(2+) -signalling dysregulation or toxicity in pancreatic acinar cells

ABT-199（维奈托克）是一种BH3模拟物Bcl-2抑制剂，不会引起胰腺腺泡细胞的Ca(2+)信号传导紊乱或毒性。

Calcium signalling in the acinar environment of the exocrine pancreas: physiology and pathophysiology

外分泌胰腺腺泡环境中的钙信号传导：生理学和病理生理学

BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides

BH3 模拟物在胰腺腺泡细胞中诱发的 Ca2+ 信号依赖于 Bax，并且可被 Ca2+ 样肽降低

Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium-driven bile uptake

胆汁酸诱导胰腺星状细胞坏死，这一过程依赖于钙离子内流和钠离子驱动的胆汁吸收。

Ca(2+) signals mediated by bradykinin type 2 receptors in normal pancreatic stellate cells can be inhibited by specific Ca(2+) channel blockade

正常胰腺星状细胞中缓激肽 2 型受体介导的 Ca(2+) 信号可被特异性 Ca(2+) 通道阻滞剂抑制