日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

De novo designed proteins neutralize lethal snake venom toxins

从头设计的蛋白质能够中和致命的蛇毒毒素

Vázquez Torres, Susana; Benard Valle, Melisa; Mackessy, Stephen P; Menzies, Stefanie K; Casewell, Nicholas R; Ahmadi, Shirin; Burlet, Nick J; Muratspahić, Edin; Sappington, Isaac; Overath, Max D; Rivera-de-Torre, Esperanza; Ledergerber, Jann; Laustsen, Andreas H; Boddum, Kim; Bera, Asim K; Kang, Alex; Brackenbrough, Evans; Cardoso, Iara A; Crittenden, Edouard P; Edge, Rebecca J; Decarreau, Justin; Ragotte, Robert J; Pillai, Arvind S; Abedi, Mohamad; Han, Hannah L; Gerben, Stacey R; Murray, Analisa; Skotheim, Rebecca; Stuart, Lynda; Stewart, Lance; Fryer, Thomas J A; Jenkins, Timothy P; Baker, David

Diffusing protein binders to intrinsically disordered proteins.

将蛋白质结合剂扩散到固有无序蛋白质上

Liu Caixuan, Wu Kejia, Choi Hojun, Han Hannah L, Zhang Xueli, Watson Joseph L, Ahn Green, Zhang Jason Z, Shijo Sara, Good Lydia L, Fischer Charlotte M, Bera Asim K, Kang Alex, Brackenbrough Evans, Coventry Brian, Hick Derrick R, Qamar Seema, Li Xinting, Decarreau Justin, Gerben Stacey R, Yang Wei, Goreshnik Inna, Vafeados Dionne, Wang Xinru, Lamb Mila, Murray Analisa, Kenny Sebastian, Bauer Magnus S, Hoofnagle Andrew N, Zhu Ping, Knowles Tuomas P J, Baker David

De Novo Design of High-Affinity Miniprotein Binders Targeting Francisella Tularensis Virulence Factor

从头设计靶向土拉弗朗西斯菌毒力因子的高亲和力微型蛋白结合剂

Gokce-Alpkilic, Gizem; Huang, Buwei; Liu, Andi; Kreuk, Lieselotte S M; Wang, Yaxi; Adebomi, Victor; Bueso, Yensi Flores; Bera, Asim K; Kang, Alex; Gerben, Stacey R; Rettie, Stephen; Vafeados, Dionne K; Roullier, Nicole; Goreshnik, Inna; Li, Xinting; Baker, David; Woodward, Joshua J; Mougous, Joseph D; Bhardwaj, Gaurav

Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

利用深度学习进行高亲和力蛋白质结合大环化合物的精确从头设计

Rettie, Stephen A; Juergens, David; Adebomi, Victor; Bueso, Yensi Flores; Zhao, Qinqin; Leveille, Alexandria N; Liu, Andi; Bera, Asim K; Wilms, Joana A; Üffing, Alina; Kang, Alex; Brackenbrough, Evans; Lamb, Mila; Gerben, Stacey R; Murray, Analisa; Levine, Paul M; Schneider, Maika; Vasireddy, Vibha; Ovchinnikov, Sergey; Weiergräber, Oliver H; Willbold, Dieter; Kritzer, Joshua A; Mougous, Joseph D; Baker, David; DiMaio, Frank; Bhardwaj, Gaurav

De novo design of high-affinity miniprotein binders targeting Francisella tularensis virulence factor.

从头设计针对土拉弗朗西斯菌毒力因子的高亲和力小蛋白结合剂

Gokce-Alpkilic Gizem, Huang Buwei, Liu Andi, Kreuk Lieselotte S M, Wang Yaxi, Adebomi Victor, Bueso Yensi Flores, Bera Asim K, Kang Alex, Gerben Stacey R, Rettie Stephen, Vafeados Dionne K, Roullier Nicole, Goreshnik Inna, Li Xinting, Baker David, Woodward Joshua J, Mougous Joseph D, Bhardwaj Gaurav

De novo design of high-affinity binders of bioactive helical peptides

从头设计高亲和力生物活性螺旋肽结合剂

Vázquez Torres, Susana; Leung, Philip J Y; Venkatesh, Preetham; Lutz, Isaac D; Hink, Fabian; Huynh, Huu-Hien; Becker, Jessica; Yeh, Andy Hsien-Wei; Juergens, David; Bennett, Nathaniel R; Hoofnagle, Andrew N; Huang, Eric; MacCoss, Michael J; Expòsit, Marc; Lee, Gyu Rie; Bera, Asim K; Kang, Alex; De La Cruz, Joshmyn; Levine, Paul M; Li, Xinting; Lamb, Mila; Gerben, Stacey R; Murray, Analisa; Heine, Piper; Korkmaz, Elif Nihal; Nivala, Jeff; Stewart, Lance; Watson, Joseph L; Rogers, Joseph M; Baker, David

Accurate de novo design of high-affinity protein binding macrocycles using deep learning

利用深度学习进行高亲和力蛋白质结合大环化合物的精确从头设计

Rettie, Stephen A; Juergens, David; Adebomi, Victor; Bueso, Yensi Flores; Zhao, Qinqin; Leveille, Alexandria N; Liu, Andi; Bera, Asim K; Wilms, Joana A; Üffing, Alina; Kang, Alex; Brackenbrough, Evans; Lamb, Mila; Gerben, Stacey R; Murray, Analisa; Levine, Paul M; Schneider, Maika; Vasireddy, Vibha; Ovchinnikov, Sergey; Weiergräber, Oliver H; Willbold, Dieter; Kritzer, Joshua A; Mougous, Joseph D; Baker, David; DiMaio, Frank; Bhardwaj, Gaurav

Diffusing protein binders to intrinsically disordered proteins

将蛋白质结合剂扩散到固有无序蛋白

Liu, Caixuan; Wu, Kejia; Choi, Hojun; Han, Hannah; Zhang, Xulie; Watson, Joseph L; Shijo, Sara; Bera, Asim K; Kang, Alex; Brackenbrough, Evans; Coventry, Brian; Hick, Derrick R; Hoofnagle, Andrew N; Zhu, Ping; Li, Xingting; Decarreau, Justin; Gerben, Stacey R; Yang, Wei; Wang, Xinru; Lamp, Mila; Murray, Analisa; Bauer, Magnus; Baker, David

Design of stimulus-responsive two-state hinge proteins

刺激响应型双态铰链蛋白的设计

Praetorius, Florian; Leung, Philip J Y; Tessmer, Maxx H; Broerman, Adam; Demakis, Cullen; Dishman, Acacia F; Pillai, Arvind; Idris, Abbas; Juergens, David; Dauparas, Justas; Li, Xinting; Levine, Paul M; Lamb, Mila; Ballard, Ryanne K; Gerben, Stacey R; Nguyen, Hannah; Kang, Alex; Sankaran, Banumathi; Bera, Asim K; Volkman, Brian F; Nivala, Jeff; Stoll, Stefan; Baker, David

Design of Diverse Asymmetric Pockets in De Novo Homo-oligomeric Proteins

从头合成的同源寡聚蛋白中多种不对称口袋的设计

Gerben, Stacey R; Borst, Andrew J; Hicks, Derrick R; Moczygemba, Isabelle; Feldman, David; Coventry, Brian; Yang, Wei; Bera, Asim K; Miranda, Marcos; Kang, Alex; Nguyen, Hannah; Baker, David