日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multiomic Immune Profiling of Pediatric Transplant Recipients Identifies Cell States Associated with Vaccine Response

对儿童移植受者进行多组学免疫分析,可识别与疫苗反应相关的细胞状态

Wedel, Johannes; Tang, Ying; Alsairafi, Bayan; Do, Vicki; Maslyar, Madeline; Fleming, Ryan; Schwartz, Marc A; Gerdemann, Ulrike; Albanese, Alexandre; Mitsialis, Vanessa; Collen, Lauren V; Nishitani, Miki; Bresnahan, Mairead; Saccocia, Gwen; Bearup, Richelle; Okoroafor, Ibeawuchi; Siegel, Steven J; Wachter, Franziska; Waters, Katherine; Weichert-Leahey, Nina; Clarke, Nigel J; Mandl, Kenneth D; Kean, Leslie S; Snapper, Scott B; Briscoe, David M; Horwitz, Bruce H

A single dose of a CD137 antibody-drug conjugate protects rhesus macaque allogeneic HCT recipients against acute GVHD

单剂量CD137抗体药物偶联物可保护恒河猴同种异体造血干细胞移植受者免受急性移植物抗宿主病(GVHD)的侵害。

Gerdemann, Ulrike; Kimler, Kyle; Warren, Matthew R; McGuckin, Connor; Fleming, Ryan A; D'Ambra, Matthew R; Eran, Alal; Albanese, Alexandre; Chen, Edward; Winschel, Marlana; Cagnin, Lorenzo; Lane, Jennifer; Gorfinkel, Lev; Adams, Bartley; Kwun, Jean; Lanieri, Leanne; Hoban, Megan; Lamothe, Tahirih L; Hyzy, Sharon; Olson, Lisa M; Panoskaltsis-Mortari, Angela; Prockop, Susan E; Blazar, Bruce R; Kean, Leslie S; Tkachev, Victor

Organ-specific microenvironments drive divergent T cell evolution in acute graft-versus-host disease

器官特异性微环境驱动急性移植物抗宿主病中T细胞的分化进化

Omdahl, Kayleigh Ingersoll; Bermea, Rene S; Fleming, Ryan; Kimler, Kyle; Kaminski, James; Hariri, Lida P; Ly, Amy; Rui, Xianliang; Cagnin, Lorenzo; Lane, Jennifer; Gerdemann, Ulrike; Blazar, Bruce R; Tkachev, Victor; Kean, Leslie S

PTPN2-KO CAR-T Cells Demonstrate Enhanced Effector Function, CNS Infiltration, and Toxicity in a Non-Human Primate CAR-T Model

在非人灵长类动物CAR-T模型中,PTPN2-KO CAR-T细胞表现出增强的效应功能、中枢神经系统浸润和毒性。

Alvarez Calderon, Francesca; Fleming, Ryan A; Winschel, Marlana; Gorfinkel, Lev; Sutherland, Rebecca; Michaelis, Katherine; Kaminski, James; Palato, Elisa Rojas; Ingersoll, Kayleigh; Cagnin, Lorenzo; Lane, Jennifer; Tkachev, Victor; Kean, Leslie S; Gerdemann, Ulrike

Precision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular Therapies

对环孢素A进行精准编辑可产生对环孢素和沃克洛孢素耐药的细胞疗法

Wobma, Holly; Alvarez Calderon, Francesca; Dong, Jiayi; Omdahl, Kayleigh; Rui, Xianliang; Rojas Palato, Elisa J; Bermea, Rene S; Albanese, Alexandre; Wachter, Franziska; Winschel, Marlana; Michaelis, Katherine A; Cagnin, Lorenzo; Tkachev, Victor; Prockop, Susan E; Nigrovic, Peter A; Blazar, Bruce R; Gerdemann, Ulrike; Kean, Leslie S

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice

在经 CD45 抗体药物偶联物预处理的范可尼贫血小鼠中,同种异体移植未出现明显毒性或移植物抗宿主病 (GVHD)。

Saha, Asim; Palchaudhuri, Rahul; Lanieri, Leanne; Hyzy, Sharon; Riddle, Megan J; Panthera, Jamie; Eide, Cindy R; Tolar, Jakub; Panoskaltsis-Mortari, Angela; Gorfinkel, Lev; Tkachev, Victor; Gerdemann, Ulrike; Alvarez-Calderon, Francesca; Palato, Elisa Rojas; MacMillan, Margaret L; Wagner, John E; Kean, Leslie S; Osborn, Mark J; Kiem, Hans-Peter; Scadden, David T; Olson, Lisa M; Blazar, Bruce R

B-cell-directed CAR T-cell therapy activates CD8+ cytotoxic CARneg bystander T cells in patients and nonhuman primates

B细胞靶向CAR-T细胞疗法可激活患者和非人灵长类动物体内的CD8+细胞毒性CAR-Neg旁观者T细胞。

Kaminski, James; Fleming, Ryan A; Alvarez-Calderon, Francesca; Winschel, Marlana B; McGuckin, Connor; Ho, Emily E; Eng, Fay; Rui, Xianliang; Keskula, Paula; Cagnin, Lorenzo; Charles, Joanne; Zavistaski, Jillian; Margossian, Steven P; Kapadia, Malika A; Rottman, James B; Lane, Jennifer; Baumeister, Susanne H C; Tkachev, Victor; Shalek, Alex K; Kean, Leslie S; Gerdemann, Ulrike

Human OX40L-CAR-T(regs) target activated antigen-presenting cells and control T cell alloreactivity.

人类 OX40L-CAR-T(regs) 靶向活化的抗原呈递细胞并控制 T 细胞同种异体反应性

Rui Xianliang, Alvarez Calderon Francesca, Wobma Holly, Gerdemann Ulrike, Albanese Alexandre, Cagnin Lorenzo, McGuckin Connor, Michaelis Katherine A, Naqvi Kisa, Blazar Bruce R, Tkachev Victor, Kean Leslie S

Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates

Notch信号通路驱动小鼠和非人灵长类动物的肠道移植物抗宿主病

Tkachev, Victor; Vanderbeck, Ashley; Perkey, Eric; Furlan, Scott N; McGuckin, Connor; Gómez Atria, Daniela; Gerdemann, Ulrike; Rui, Xianliang; Lane, Jennifer; Hunt, Daniel J; Zheng, Hengqi; Colonna, Lucrezia; Hoffman, Michelle; Yu, Alison; Outen, Riley; Kelly, Samantha; Allman, Anneka; Koch, Ute; Radtke, Freddy; Ludewig, Burkhard; Burbach, Brandon; Shimizu, Yoji; Panoskaltsis-Mortari, Angela; Chen, Guoying; Carpenter, Stephen M; Harari, Olivier; Kuhnert, Frank; Thurston, Gavin; Blazar, Bruce R; Kean, Leslie S; Maillard, Ivan

Epigenetic scars of CD8(+) T cell exhaustion persist after cure of chronic infection in humans

人类慢性感染治愈后,CD8(+) T细胞耗竭的表观遗传痕迹仍然存在。

Yates, Kathleen B; Tonnerre, Pierre; Martin, Genevieve E; Gerdemann, Ulrike; Al Abosy, Rose; Comstock, Dawn E; Weiss, Sarah A; Wolski, David; Tully, Damien C; Chung, Raymond T; Allen, Todd M; Kim, Arthur Y; Fidler, Sarah; Fox, Julie; Frater, John; Lauer, Georg M; Haining, W Nicholas; Sen, Debattama R