日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Interference of Large Clostridial Glucosyltransferases with the Endolysosomal Pathway: Toxin-Induced Imbalance of Early Endosomes, Functional Lysosomes and Autophagosomes

大型梭菌葡糖基转移酶对内溶酶体途径的干扰:毒素诱导的早期内体、功能性溶酶体和自噬体失衡

Langejürgen, Anna; Schmidt, Gudula; Unsöld, Leon; Tatge, Helma; Oyson, Ethel; Gerhard, Ralf

CDT of Clostridioides difficile Induces MLC-Dependent Intestinal Barrier Dysfunction in HT-29/B6 Epithelial Cell Monolayers

艰难梭菌的CDT诱导HT-29/B6上皮细胞单层中MLC依赖性肠道屏障功能障碍

Heils, Lucas; Schneemann, Martina; Gerhard, Ralf; Schulzke, Jörg-Dieter; Bücker, Roland

The Conserved Cys-2232 in Clostridioides difficile Toxin B Modulates Receptor Binding

艰难梭菌毒素B中的保守Cys-2232调节受体结合

Chung, Soo-Young; Schöttelndreier, Dennis; Tatge, Helma; Fühner, Viola; Hust, Michael; Beer, Lara-Antonia; Gerhard, Ralf

Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficile

噬菌体衍生溶素/内溶素系统适应艰难梭菌毒素运输的证据

Mehner-Breitfeld, Denise; Rathmann, Claudia; Riedel, Thomas; Just, Ingo; Gerhard, Ralf; Overmann, Jörg; Brüser, Thomas

The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains.

艰难梭菌二元毒素 CDT 作为细菌葡萄糖基转移酶结构域胞内递送的工具

Beer Lara-Antonia, Tatge Helma, Schneider Carmen, Ruschig Maximilian, Hust Michael, Barton Jessica, Thiemann Stefan, Fühner Viola, Russo Giulio, Gerhard Ralf

Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B

活性氧作为艰难梭菌毒素A和B细胞毒性的其他决定因素

Frädrich, Claudia; Beer, Lara-Antonia; Gerhard, Ralf

The combined repetitive oligopeptides of clostridium difficile toxin A counteract premature cleavage of the glucosyl-transferase domain by stabilizing protein conformation

艰难梭菌毒素A的重复寡肽组合通过稳定蛋白质构象来抵消葡萄糖基转移酶结构域的过早切割。

Olling, Alexandra; Hüls, Corinna; Goy, Sebastian; Müller, Mirco; Krooss, Simon; Rudolf, Isa; Tatge, Helma; Gerhard, Ralf

Rac function is crucial for cell migration but is not required for spreading and focal adhesion formation

Rac功能对细胞迁移至关重要,但并非细胞铺展和黏着斑形成所必需。

Steffen, Anika; Ladwein, Markus; Dimchev, Georgi A; Hein, Anke; Schwenkmezger, Lisa; Arens, Stefan; Ladwein, Kathrin I; Margit Holleboom, J; Schur, Florian; Victor Small, J; Schwarz, Janett; Gerhard, Ralf; Faix, Jan; Stradal, Theresia E B; Brakebusch, Cord; Rottner, Klemens

Serine-71 phosphorylation of Rac1 modulates downstream signaling.

Rac1 的丝氨酸 71 位点磷酸化调节下游信号传导

Schwarz Janett, Proff Julia, Hävemeier Anika, Ladwein Markus, Rottner Klemens, Barlag Britta, Pich Andreas, Tatge Helma, Just Ingo, Gerhard Ralf

The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A

重复的寡肽序列可以调节细胞病变效力,但对艰难梭菌毒素A的细胞摄取并非至关重要。

Olling, Alexandra; Goy, Sebastian; Hoffmann, Florian; Tatge, Helma; Just, Ingo; Gerhard, Ralf