日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Inhibition of BACE1 affected both its Aβ producing and degrading activities and increased Aβ42 and Aβ40 levels at high-level BACE1 expression

抑制 BACE1 会影响其 Aβ 生成和降解活性,并在 BACE1 高水平表达时增加 Aβ42 和 Aβ40 水平

Irem Ulku, Rocher Leung, Fritz Herre, Lina Walther, Adeola Shobo, Paul Saftig, Mark A Hancock, Filip Liebsch, Gerhard Multhaup

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis

淀粉样蛋白-β34 的生成机制表明 BACE1 在淀粉样蛋白稳态中起着关键作用

Irem Ulku, Filip Liebsch, S Can Akerman, Jana F Schulz, Luka Kulic, Christoph Hock, Claus Pietrzik, Alessandro Di Spiezio, Gopal Thinakaran, Paul Saftig, Gerhard Multhaup

Cathepsin D: Analysis of its potential role as an amyloid beta degrading protease

组织蛋白酶 D:分析其作为淀粉样β蛋白降解蛋白酶的潜在作用

Lisa Gallwitz, Lina Schmidt, André R A Marques, Andreas Tholey, Liam Cassidy, Irem Ulku, Gerhard Multhaup, Alessandro Di Spiezio, Paul Saftig

The amyloid-β1-42-oligomer interacting peptide D-AIP possesses favorable biostability, pharmacokinetics, and brain region distribution

淀粉样蛋白-β1-42-寡聚体相互作用肽 D-AIP 具有良好的生物稳定性、药代动力学和脑区分布

Adeola Shobo, Nicholas James, Daniel Dai, Alexander Röntgen, Corbin Black, Jean-Robert Kwizera, Mark A Hancock, Khanh Huy Bui, Gerhard Multhaup

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression

Aβ34 是一种 BACE1 衍生的降解中间体,与淀粉样蛋白清除和阿尔茨海默病进展有关

Filip Liebsch, Luka Kulic, Charlotte Teunissen, Adeola Shobo, Irem Ulku, Vivienne Engelschalt, Mark A Hancock, Wiesje M van der Flier, Peter Kunach, Pedro Rosa-Neto, Philip Scheltens, Judes Poirier, Paul Saftig, Randall J Bateman, John Breitner, Christoph Hock, Gerhard Multhaup

The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease

淀粉样蛋白-β 降解中间体 Aβ34 与周细胞有关,并且在阿尔茨海默病患者的脑毛细血管中减少

Tunahan Kirabali, Serena Rigotti, Alessandro Siccoli, Filip Liebsch, Adeola Shobo, Christoph Hock, Roger M Nitsch, Gerhard Multhaup, Luka Kulic

Label-free distribution of anti-amyloid D-AIP in Drosophila melanogaster: prevention of Aβ42-induced toxicity without side effects in transgenic flies

抗淀粉样蛋白 D-AIP 在果蝇体内的无标记分布:预防转基因果蝇中 Aβ42 诱导的毒性且无副作用

Yifei Zhong, Adeola Shobo, Mark A Hancock, Gerhard Multhaup

Hyperbranched Polyglycerol Derivatives as Prospective Copper Nanotransporter Candidates

超支化聚甘油衍生物作为潜在的铜纳米转运体候选物

Mohiuddin Quadir, Susanne Fehse, Gerhard Multhaup, Rainer Haag

APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding

APLP1被γ-分泌酶内切,无需先前的胞外域脱落。

Linda Schauenburg, Filip Liebsch, Murat Eravci, Magnus C Mayer, Christoph Weise, Gerhard Multhaup

Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide

阿尔茨海默病Aβ纤维与非甾体抗炎药(NSAID)舒林酸硫化物相互作用的结构机制

Prade, Elke; Bittner, Heiko J; Sarkar, Riddhiman; Lopez Del Amo, Juan Miguel; Althoff-Ospelt, Gerhard; Multhaup, Gerd; Hildebrand, Peter W; Reif, Bernd