日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mdm2 targeting via PROteolysis TArgeting Chimeras (PROTAC) is efficient in p53 wildtype, p53-mutated, and abemaciclib-resistant estrogen receptor-positive cell lines and superior to mdm2 inhibition

通过蛋白水解靶向嵌合体(PROTAC)靶向mdm2在p53野生型、p53突变型和对阿贝西利耐药的雌激素受体阳性细胞系中均有效,并且优于mdm2抑制剂。

Alina Goerg ,Gerhard Piendl ,Veruschka Albert ,Olaf Ortmann ,Anja Kathrin Wege ,Gero Brockhoff

HER4 Affects Sensitivity to Tamoxifen and Abemaciclib in Luminal Breast Cancer Cells and Restricts Tumor Growth in MCF-7-Based Humanized Tumor Mice

HER4影响管腔型乳腺癌细胞对他莫昔芬和阿贝西利的敏感性,并限制基于MCF-7的人源化肿瘤小鼠的肿瘤生长

Veruschka Albert ,Christina Bruss ,Deniz Tümen ,Gerhard Piendl ,Florian Weber ,Edgar Dahl ,Stephan Seitz ,Olaf Ortmann ,Anja K Wege ,Gero Brockhoff

Protein kinase C targeting of luminal (T-47D), luminal/HER2-positive (BT474), and triple negative (HCC1806) breast cancer cells in-vitro with AEB071 (Sotrastaurin) is efficient but mediated by subtype specific molecular effects

蛋白激酶 C 在体外利用 AEB071 (Sotrastaurin) 靶向作用于管腔 (T-47D)、管腔/HER2 阳性 (BT474) 和三阴性 (HCC1806) 乳腺癌细胞是有效的,但由亚型特异性分子效应介导

Veruschka Albert, Gerhard Piendl, Dali Yousseff, Hedwig Lammert, Michael Hummel, Olaf Ortmann, Wolfgang Jagla, Andreas Gaumann, Anja K Wege, Gero Brockhoff

Differential Expression of PD-L1 during Cell Cycle Progression of Head and Neck Squamous Cell Carcinoma

头颈部鳞状细胞癌细胞周期进程中PD-L1的差异表达

Daniela Schulz, Martin Wetzel, Jonas Eichberger, Gerhard Piendl, Gero Brockhoff, Anja K Wege, Torsten E Reichert, Tobias Ettl, Richard J Bauer

A novel rabbit derived anti-HER2 antibody with pronounced therapeutic effectiveness on HER2-positive breast cancer cells in vitro and in humanized tumor mice (HTM)

一种新型兔源抗 HER2 抗体,在体外和人源化肿瘤小鼠(HTM)中对 HER2 阳性乳腺癌细胞具有显著的治疗效果

Anja Kathrin Wege, Nicole Kirchhammer, Linda Veronique Kazandjian, Sandra Prassl, Michael Brandt, Gerhard Piendl, Olaf Ortmann, Stephan Fischer, Gero Brockhoff