日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Charge matters: how flanking substrate charge modulates O-glycan Core elongation

电荷很重要:侧翼底物电荷如何调节O-聚糖核心的延伸

Ballard, Collin J; Smutny, Matthew R; Chau, Lam D; Wong, Collin K; Aharoni, Haley M; Lee, Hana K; Chapla, Digantkumar G; Hurtado-Guerrero, Ramon; Moremen, Kelley W; Gerken, Thomas A

Rational Design of Dual-Domain Binding Inhibitors for N-Acetylgalactosamine Transferase 2 with Improved Selectivity over the T1 and T3 Isoforms

合理设计对N-乙酰半乳糖胺转移酶2具有更高选择性的双结构域结合抑制剂(针对T1和T3亚型)

Compañón, Ismael; Ballard, Collin J; Lira-Navarrete, Erandi; Santos, Tanausú; Monaco, Serena; Muñoz-García, Juan C; Delso, Ignacio; Angulo, Jesus; Gerken, Thomas A; Schjoldager, Katrine T; Clausen, Henrik; Tejero, Tomás; Merino, Pedro; Corzana, Francisco; Hurtado-Guerrero, Ramon; Ghirardello, Mattia

Polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) isozyme surface charge governs charge substrate preferences to modulate mucin type O-glycosylation

多肽N-乙酰半乳糖胺转移酶(GalNAc-T)同工酶的表面电荷决定了底物偏好性,从而调节粘蛋白型O-糖基化。

Ballard, Collin J; Paserba, Miya R; Paul Daniel, Earnest James; Hurtado-Guerrero, Ramón; Gerken, Thomas A

ISOGlyP: de novo prediction of isoform-specific mucin-type O-glycosylation

ISOGlyP:从头预测同工型特异性粘蛋白型 O-糖基化

Mohl, Jonathon E; Gerken, Thomas A; Leung, Ming-Ying

Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences

O-糖基转移酶凝集素结构域的差异性剪接可调节其对肽和糖肽的偏好性。

May, Carolyn; Ji, Suena; Syed, Zulfeqhar A; Revoredo, Leslie; Paul Daniel, Earnest James; Gerken, Thomas A; Tabak, Lawrence A; Samara, Nadine L; Ten Hagen, Kelly G

Ser and Thr acceptor preferences of the GalNAc-Ts vary among isoenzymes to modulate mucin-type O-glycosylation

GalNAc-Ts对Ser和Thr受体的偏好性因同工酶而异,从而调节粘蛋白型O-糖基化。

Daniel, Earnest James Paul; Las Rivas, Matilde; Lira-Navarrete, Erandi; García-García, Ana; Hurtado-Guerrero, Ramon; Clausen, Henrik; Gerken, Thomas A

Polypeptide GalNAc-Ts: from redundancy to specificity

多肽 GalNAc-Ts:从冗余到特异性

de Las Rivas, Matilde; Lira-Navarrete, Erandi; Gerken, Thomas A; Hurtado-Guerrero, Ramon

Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4

GalNAc-T4催化结构域介导的短程糖基化偏好的结构和机制研究

de Las Rivas, Matilde; Paul Daniel, Earnest James; Coelho, Helena; Lira-Navarrete, Erandi; Raich, Lluis; Compañón, Ismael; Diniz, Ana; Lagartera, Laura; Jiménez-Barbero, Jesús; Clausen, Henrik; Rovira, Carme; Marcelo, Filipa; Corzana, Francisco; Gerken, Thomas A; Hurtado-Guerrero, Ramon

Evidence for GALNT12 as a moderate penetrance gene for colorectal cancer.

证据表明 GALNT12 是结直肠癌的中等外显率基因

Evans Daniel R, Venkitachalam Srividya, Revoredo Leslie, Dohey Amanda T, Clarke Erica, Pennell Julia J, Powell Amy E, Quinn Erina, Ravi Lakshmeswari, Gerken Thomas A, Green Jane S, Woods Michael O, Guda Kishore

Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions

Tn 和 STn 属于碳水化合物肿瘤抗原家族,该家族具有碳水化合物-碳水化合物相互作用。

Sletmoen, Marit; Gerken, Thomas A; Stokke, Bjørn T; Burchell, Joy; Brewer, C Fred