Gernoux相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

AAV-mediated inner ear gene delivery triggers mild host immune responses in the mammalian inner ear.

AAV介导的内耳基因递送可引发哺乳动物内耳中轻微的宿主免疫反应

期刊:Molecular Therapy-Methods & Clinical Development

影响因子:4.7

doi:10.1016/j.omtm.2025.101456

Ishibashi Yasuko, Zhu Jianliang, Gernoux Gwladys, Yu Yunkai, Suh Michelle J, Isgrig Kevin, Grati Mhamed, Olszewski Rafal, Hoa Michael, Liang Cao, Friedman Thomas B, Adjali Oumeya, Chien Wade W

免疫/内分泌

发表日期：2025

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Incomplete elimination of viral genomes is associated with chronic inflammation in nonhuman primate livers after AAV-mediated gene transfer

AAV介导的基因转移后，非人灵长类动物肝脏中病毒基因组清除不完全与慢性炎症有关。

期刊:Gene Therapy

影响因子:4.5

doi:10.1038/s41434-025-00514-z

Pichard, Virginie; Guilbaud, Mickaël; Devaux, Marie; Jaulin, Nicolas; Journou, Malo; Cospolite, Magalie; Garcia, Alexandra; Ferry, Nicolas; Michalak-Provost, Sophie; Gernoux, Gwladys; Adjali, Oumeya

发表日期：2025

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Biodistribution and safety of a single rAAV3B-AAT vector for silencing and replacement of alpha-1 antitrypsin in Cynomolgus macaques

单个 rAAV3B-AAT 载体在猕猴体内沉默和替代 alpha-1 抗胰蛋白酶的生物分布和安全性

期刊:Molecular Therapy-Methods & Clinical Development

doi:10.1016/j.omtm.2024.101200

Meghan Blackwood, Alisha M Gruntman, Qiushi Tang, Debora Pires-Ferreira, Darcy Reil, Oleksandr Kondratov, Damien Marsic, Sergei Zolotukhin, Gwladys Gernoux, Allison M Keeler, Christian Mueller, Terence R Flotte

发表日期：2024

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Transcriptomic Analysis Reveals the Inability of Recombinant AAV8 to Activate Human Monocyte-Derived Dendritic Cells

转录组分析揭示重组AAV8无法激活人单核细胞来源的树突状细胞

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms241310447

Masri, Samer; Carré, Laure; Jaulin, Nicolas; Vandamme, Céline; Couzinié, Célia; Guy-Duché, Aurélien; Dupont, Jean-Baptiste; Pereira, Allwyn; Charpentier, Eric; David, Laurent; Gernoux, Gwladys; Guilbaud, Mickaël; Adjali, Oumeya

树突状细胞

细胞生物学

树突状细胞

免疫/内分泌

发表日期：2023

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AAV gene therapy for Tay-Sachs disease

Tay-Sachs 病的 AAV 基因治疗

期刊:Nature Medicine

影响因子:58.7

doi:10.1038/s41591-021-01664-4

Terence R Flotte, Oguz Cataltepe, Ajit Puri, Ana Rita Batista, Richard Moser, Diane McKenna-Yasek, Catherine Douthwright, Gwladys Gernoux, Meghan Blackwood, Christian Mueller, Phillip W L Tai, Xuntian Jiang, Scot Bateman, Spiro G Spanakis, Julia Parzych, Allison M Keeler, Aly Abayazeed, Saurabh Roha

发表日期：2022

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Liver-directed SERPINA1 gene therapy attenuates progression of spontaneous and tobacco smoke-induced emphysema in α1-antitrypsin null mice

肝脏定向 SERPINA1 基因治疗可减轻 α1-抗胰蛋白酶缺陷小鼠自发性肺气肿和烟草烟雾诱发性肺气肿的进展

期刊:Molecular Therapy-Methods & Clinical Development

doi:10.1016/j.omtm.2022.04.003

Marina Zieger, Florie Borel, Cynthia Greer, Gwladys Gernoux, Meghan Blackwood, Terence R Flotte, Christian Mueller

发表日期：2022

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AAV8 locoregional delivery induces long-term expression of an immunogenic transgene in macaques despite persisting local inflammation

尽管局部炎症持续存在，AAV8 局部区域递送仍可在恒河猴体内诱导免疫原性转基因的长期表达

期刊:Molecular Therapy-Methods & Clinical Development

doi:10.1016/j.omtm.2021.02.003

Gwladys Gernoux, Mickaël Guilbaud, Marie Devaux, Malo Journou, Virginie Pichard, Nicolas Jaulin, Adrien Léger, Johanne Le Duff, Jack-Yves Deschamps, Caroline Le Guiner, Philippe Moullier, Yan Cherel, Oumeya Adjali

发表日期：2021

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SOD1 Suppression with Adeno-Associated Virus and MicroRNA in Familial ALS

腺相关病毒和microRNA抑制家族性ALS中的SOD1

期刊:New England Journal of Medicine

影响因子:78.5

doi:10.1056/NEJMoa2005056

Mueller, Christian; Berry, James D; McKenna-Yasek, Diane M; Gernoux, Gwladys; Owegi, Margaret A; Pothier, Lindsay M; Douthwright, Catherine L; Gelevski, Dario; Luppino, Sarah D; Blackwood, Meghan; Wightman, Nicholas S; Oakley, Derek H; Frosch, Matthew P; Flotte, Terrence R; Cudkowicz, Merit E; Brown, Robert H Jr

发表日期：2020

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Muscle-Directed Delivery of an AAV1 Vector Leads to Capsid-Specific T Cell Exhaustion in Nonhuman Primates and Humans

肌肉定向递送AAV1载体可导致非人灵长类动物和人类体内衣壳特异性T细胞耗竭

期刊:Molecular Therapy

影响因子:12.1

doi:10.1016/j.ymthe.2020.01.004

Gwladys Gernoux ，Alisha M Gruntman ，Meghan Blackwood ，Marina Zieger ，Terence R Flotte ，Christian Mueller

细胞生物学

免疫/内分泌

发表日期：2020

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CHOP and c-JUN up-regulate the mutant Z α1-antitrypsin, exacerbating its aggregation and liver proteotoxicity

CHOP 和 c-JUN 上调突变的 Z α1-抗胰蛋白酶，加剧其聚集和肝脏蛋白毒性

期刊:Journal of Biological Chemistry

doi:10.1074/jbc.RA120.014307

Sergio Attanasio, Rosa Ferriero, Gwladys Gernoux, Rossella De Cegli, Annamaria Carissimo, Edoardo Nusco, Severo Campione, Jeffrey Teckman, Christian Mueller, Pasquale Piccolo, Nicola Brunetti-Pierri

发表日期：2020

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