NRF2 activators and the inhibitor of nuclear export, selinexor, restrict coronaviruses by targeting a network involving ACE2, TMPRSS2, and XPO1 through an NRF2-independent mechanism.
NRF2 激活剂和核输出抑制剂 selinexor 通过一种不依赖于 NRF2 的机制,靶向涉及 ACE2、TMPRSS2 和 XPO1 的网络,从而限制冠状病毒。
期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-026-09724-6
Waqas Fakhar H, Silva da Costa Leandro, Zapatero-Belinchón Francisco J, Carter-Timofte Madalina E, Lasswitz Lisa, van der Horst Demi, Möller Rebecca, Dahlmann Julia, Olmer Ruth, Geffers Robert, Gerold Gisa, Olagnier David, Pessler Frank